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Journal of Materials Science

Erschienen in:

06.07.2020 | Materials for life sciences

Multifunctional Ag/polymer composite nanospheres for drug delivery and cell imaging

verfasst von: Yang Wang, Doudou Gao, Dong Zhou, Yulin Li, Xianxun Wang, Peixin He, Yuhong Zhang

Erschienen in: Journal of Materials Science | Ausgabe 28/2020

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Abstract

Judicious combination of noble metals and smart gels makes cell imaging and drug delivery into one, which provides support for the integrated technology of diagnosis and treatment. In this work, the Ag nanoparticles (Ag NPs)/poly-(N-isopropylacrylamide-co-dimethylaminoethylmethacrylate) core–shell multifunctional composite nanosphere (Ag–p (NIPAM-co-DMAEMA)) was successfully synthesized by two-step one-pot method. The composite nanospheres had a particle size of approximately 200 nm and possessed multiple sensitive release properties, biocompatibility, and pharmacological activity. Importantly, it was found that cancer cells (CT-26) uptake more hybrid gels and exhibited stronger fluorescence, compared to normal cells (COS-7). This indicated that the hybrid gel had certain specificity and could be used for the imaging of cancer cells. Multifunctional composite nanospheres with optical and therapeutic functionality constructed by a simple method offered broad opportunities for cancer treatment and cell imaging.

Vorheriger Artikel A sandwich-type electrochemical immunosensor for ultrasensitive detection of CEA based on core–shell Cu2O@Cu-MOF@Au NPs nanostructure attached with HRP for triple signal amplification

Nächster Artikel In situ fabrication of anatase thin films with high percentage of exposed {001} facets to improve biocompatibility with MC3T3-E1 cells

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Titel: Multifunctional Ag/polymer composite nanospheres for drug delivery and cell imaging
verfasst von: Yang Wang
Doudou Gao
Dong Zhou
Yulin Li
Xianxun Wang
Peixin He
Yuhong Zhang
Publikationsdatum: 06.07.2020
Verlag: Springer US
Erschienen in: Journal of Materials Science / Ausgabe 28/2020
Print ISSN: 0022-2461
Elektronische ISSN: 1573-4803
DOI: https://doi.org/10.1007/s10853-020-04912-z

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