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Erschienen in: Medical & Biological Engineering & Computing 5/2008

01.05.2008 | Special Issue

Plasma detection of NO by a catheter

verfasst von: Masami Goto, Seiichi Mochizuki

Erschienen in: Medical & Biological Engineering & Computing | Ausgabe 5/2008

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Abstract

Nitric oxide (NO) released by endothelial cells in response to hemodynamic shear stress is a key controller molecule of the vascular functions and antiatherogenic mechanisms. Endothelial dysfunction is associated with increased cardiovascular events. Therefore, several indirect techniques have been employed to evaluate endothelial function or NO bioavailability. However, a growing body of evidences suggests limitations of the indirect methods for evaluation of NO bioavailability. In years, it has been considered that NO is immediately oxidized or inactivated in blood stream. However, recent studies suggest that NO remain active in blood stream, causing remote biological response. Therefore, measuring plasma NO concentration directly in the circulation will contribute to clarify the kinetics and physiological roles of NO and to evaluate endothelial function. In this article, the measurement of plasma NO concentration using a newly developed catheter-type NO sensor will be described.

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Metadaten
Titel
Plasma detection of NO by a catheter
verfasst von
Masami Goto
Seiichi Mochizuki
Publikationsdatum
01.05.2008
Verlag
Springer Berlin Heidelberg
Erschienen in
Medical & Biological Engineering & Computing / Ausgabe 5/2008
Print ISSN: 0140-0118
Elektronische ISSN: 1741-0444
DOI
https://doi.org/10.1007/s11517-008-0333-z

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