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Journal of Nanoparticle Research
Erschienen in: Journal of Nanoparticle Research 4/2013

01.04.2013 | Research Paper

Protective effect of quercetin and/or l-arginine against nano-zinc oxide-induced cardiotoxicity in rats

verfasst von: L. M. Faddah, Nayira A. Abdel Baky, Azza M. Mohamed, Nouf M. Al-Rasheed, Nawal M. Al-Rasheed

Erschienen in: Journal of Nanoparticle Research | Ausgabe 4/2013

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Abstract

The aim of this study was to investigate the protective role of quercetin and/or l-arginine against the cardiotoxic potency of zinc oxide nanoparticle (ZnO-NP)-induced cardiac infarction. ZnO-NPs (50 nm) were administered orally at either 600 mg or 1 g/kg body weight for 5 consecutive days. The results revealed that co-administration of quercetin and/or l-arginine (each 200 mg/kg body weight) daily for 3 weeks to rats intoxicated by either of the two doses markedly ameliorated increases in serum markers of cardiac infarction, including troponin T, creatine kinase-MB, and myoglobin, as well as increases in proinflammatory biomarkers, including tumor necrosis factor-α, interleukin-6, and C-reactive protein, compared with intoxicated, untreated rats. Each agent alone or in combination also successfully modulated the alterations in serum vascular endothelial growth factor, cardiac calcium concentration, and oxidative DNA damage as well as the increase in the apoptosis marker caspase 3 of cardiac tissue in response to ZnO-NP toxicity. In conclusion, early treatment with quercetin and l-arginine may protect cardiac tissue from infarction induced by the toxic effects of ZnO-NPs.
Vorheriger Artikel Nanosafety by design: risks from nanocomposite/nanowaste combustion
Nächster Artikel Conducting polymer hydrogel reactor for synthesizing Au nanoparticles and its use in the reduction of p-nitrophenol

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Metadaten
Titel
Protective effect of quercetin and/or l-arginine against nano-zinc oxide-induced cardiotoxicity in rats
verfasst von
L. M. Faddah
Nayira A. Abdel Baky
Azza M. Mohamed
Nouf M. Al-Rasheed
Nawal M. Al-Rasheed
Publikationsdatum
01.04.2013
Verlag
Springer Netherlands
Erschienen in
Journal of Nanoparticle Research / Ausgabe 4/2013
Print ISSN: 1388-0764
Elektronische ISSN: 1572-896X
DOI
https://doi.org/10.1007/s11051-013-1520-x

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