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01.06.2015

Psychometric assessment of health-related quality of life and symptom experience in HIV patients treated with antiretroviral therapy

verfasst von: Christophe Lalanne, Andrew R. Armstrong, Susan Herrmann, Sophie Le Coeur, Patrizia Carrieri, Olivier Chassany, Martin Duracinsky

Erschienen in: Quality of Life Research | Ausgabe 6/2015

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Abstract

Purpose

Symptoms which are found to cluster consistently can have synergistic effects on patient outcomes and therefore may serve to predict morbidity or disentangle disease progression from comorbid conditions. Self-report HIV-specific symptom and HRQL measures were jointly analyzed in HIV-positive patients under different antiretroviral treatment regimens.

Methods

The responses of \(N=365\) patients from four countries to the 9-item Physical Health and Symptom dimension of the PROOQL-HIV questionnaire and an HIV Symptom checklist were analyzed. Item response modeling and multidimensional scaling were used to derive HRQL scores free of any differential item functioning related to gender and target language and to summarize symptom co-expression in patients under protease inhibitor treatment (PI, \(N=164\), 45 %) versus other medication (Non-PI).

Results

Women reported poorer HRQL (\(p=0.037\)), and HRQL did not differ between the target languages of French, English, and Thai. Fatigue, muscular pain, or difficulties falling asleep was the most frequently reported symptoms >35 %). PI versus Non-PI patients exhibited different pattern of symptoms with lipodystrophy-related and gastrointestinal symptoms forming well-separated clusters in the PI group. A higher number of symptoms were associated with lower HRQL (\(p < 0.001\)), and patients taking PIs reported lower HRQL (\(p=0.003\)). Patients in both groups who reported fatigue, sexual dysfunction, or several lipodystrophy-related symptoms had poorer quality of life.

Conclusion

The co-expression of symptoms and their relation to HRQL are important aspects for the monitoring of HIV treatments.

Vorheriger Artikel The relationship among caregiving characteristics, caregiver strain, and health-related quality of life: evidence from the Survey of the Health of Wisconsin

Nächster Artikel Girls’ quality of life prior to detention in relation to psychiatric disorders, trauma exposure and socioeconomic status

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Titel: Psychometric assessment of health-related quality of life and symptom experience in HIV patients treated with antiretroviral therapy
verfasst von: Christophe Lalanne
Andrew R. Armstrong
Susan Herrmann
Sophie Le Coeur
Patrizia Carrieri
Olivier Chassany
Martin Duracinsky
Publikationsdatum: 01.06.2015
Verlag: Springer International Publishing
Erschienen in: Quality of Life Research / Ausgabe 6/2015
Print ISSN: 0962-9343
Elektronische ISSN: 1573-2649
DOI: https://doi.org/10.1007/s11136-014-0880-8

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Abstract

Purpose

Methods

Results

Conclusion

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