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Quality of Life Research
Erschienen in: Quality of Life Research 8/2015

01.08.2015

Psychometric properties of the Hamilton Depression Rating Scale in multiple sclerosis

verfasst von: Simona Raimo, Luigi Trojano, Daniele Spitaleri, Vittorio Petretta, Dario Grossi, Gabriella Santangelo

Erschienen in: Quality of Life Research | Ausgabe 8/2015

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Abstract

Background

Multiple sclerosis (MS) is frequently associated with depressive symptoms and major depression.

Objective

We assessed psychometric properties of the Hamilton Depression Rating Scale (HDRS, 17-item version) for assessing depressive symptomatology in a sample of MS patients.

Methods

Seventy patients (aged 43.3 ± 10.3 years) completed the HDRS and a thorough clinical and neuropsychological assessment, including diagnosis of major depression according to the established clinical criteria.

Results

HDRS was easy to administer and acceptable, and showed fair internal consistency (Cronbach’s alpha = 0.8). The HDRS showed good convergent validity with respect to neuropsychiatric inventory (NPI) subdomain of depression (r rho = .85) and good divergent validity with respect to remaining NPI subdomains (r rho < .30). Moreover, HDRS’s total score correlated moderately with functional disability and apathetic symptomatology, and poorly with general cognitive status. Receiver operating characteristics curve analysis demonstrated that a cutoff >14.5 can identify clinically relevant depressive symptoms with good sensitivity (93 %) and specificity (97 %) with respect to the diagnosis of major depression. Such a cutoff identified clinically relevant depressive symptoms in 42 % of our MS sample, whereas 44.2 % patients met established clinical criteria for major depression.

Conclusion

The HDRS can be considered as an easy, reliable, and valid tool to assess depressive symptomatology for clinical and research purposes in non-demented MS patients.
Vorheriger Artikel Validity of the 12-item World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) in individuals with Huntington disease (HD)
Nächster Artikel Measurement properties of translated versions of the Scoliosis Research Society-22 Patient Questionnaire, SRS-22: a systematic review

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Metadaten
Titel
Psychometric properties of the Hamilton Depression Rating Scale in multiple sclerosis
verfasst von
Simona Raimo
Luigi Trojano
Daniele Spitaleri
Vittorio Petretta
Dario Grossi
Gabriella Santangelo
Publikationsdatum
01.08.2015
Verlag
Springer International Publishing
Erschienen in
Quality of Life Research / Ausgabe 8/2015
Print ISSN: 0962-9343
Elektronische ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-015-0940-8

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