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Colloid and Polymer Science

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06.07.2019 | Original Contribution

Release mechanism of lipid nanoparticles immobilized within alginate beads influenced by nanoparticle size and alginate concentration

verfasst von: Rui Sun, Qiang Xia

Erschienen in: Colloid and Polymer Science | Ausgabe 9/2019

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Abstract

The combination of hydrogels and lipid carriers has been widely used in the encapsulation of oil-soluble active ingredients. The objective of the present work was to understand the release mechanism of lipid nanoparticles (LNP) immobilized within alginate hydrogel beads. To evaluate the amount of LNP released from alginate beads, a simple method derived from dynamic light scattering was established and applied in the dissolution study effectively. The presence of LNP-mediated release was confirmed in the dissolution study. The dissolution study in simulated gastric fluids, involving diffusion-controlled release model, indicated that the LNP-mediated release was susceptible to the size of LNP and alginate concentration. The release study in simulated intestinal fluids, involving swelling-controlled release model, showed that the alginate concentration had a decisive effect on the release. This study will be helpful for the design of a new delivery system, which combines hydrogels and lipid carriers.

Vorheriger Artikel Crossover behavior on temperature dependence of volume of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide)–based hydrogels

Nächster Artikel Preparation and characterization of dimer fatty acid epoxy-acrylate resin hybrid emulsion for photocurable coatings

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Titel: Release mechanism of lipid nanoparticles immobilized within alginate beads influenced by nanoparticle size and alginate concentration
verfasst von: Rui Sun
Qiang Xia
Publikationsdatum: 06.07.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: Colloid and Polymer Science / Ausgabe 9/2019
Print ISSN: 0303-402X
Elektronische ISSN: 1435-1536
DOI: https://doi.org/10.1007/s00396-019-04538-x

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