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Cellulose
Erschienen in: Cellulose 11/2019

24.06.2019 | Original Research

Smart cellulose-derived magnetic hydrogel with rapid swelling and deswelling properties for remotely controlled drug release

verfasst von: Fengcai Lin, Junjian Zheng, Weihong Guo, Zhiting Zhu, Zi Wang, Biying Dong, Chensheng Lin, Biao Huang, Beili Lu

Erschienen in: Cellulose | Ausgabe 11/2019

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Abstract

Although cellulose hydrogels are one of promising biomaterials for drug release carrier, their passive manner of drug release and the absence of remote stimuli response limit their further applications. Herein, we report a simple one-pot method for the synthesis of magnetic β-cyclodextrin (β-CD)/cellulose hydrogel beads, which exhibited rapid swelling–deswelling properties under an external magnetic field (EMF) to remotely control drug release from passive release to stepwise release. The grafted β-CD endows the hydrogel with high drug loading capacity and, simultaneously, the incorporation of Fe3O4 nanoparticles provide the force for stepwise drug release through EMF induced rapid and reversible deformation of 3D network. We demonstrate that the efficiency of the hydrogel in the stepwise drug release dose and rate can be controlled by switching on–off the EMF and adjusting the content of Fe3O4 nanoparticles. Additionally, results from cytotoxicity tests confirmed the excellent biocompatibility of the developed hydrogel, which is promising to be used in the biomedical field.
Vorheriger Artikel Synthesis and characterization of a novel microcrystalline cellulose-based polymeric bio-sorbent and its adsorption performance for Zn(II)
Nächster Artikel Mg(OH)2 and PDMS-coated cotton fabrics for excellent oil/water separation and flame retardancy

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Metadaten
Titel
Smart cellulose-derived magnetic hydrogel with rapid swelling and deswelling properties for remotely controlled drug release
verfasst von
Fengcai Lin
Junjian Zheng
Weihong Guo
Zhiting Zhu
Zi Wang
Biying Dong
Chensheng Lin
Biao Huang
Beili Lu
Publikationsdatum
24.06.2019
Verlag
Springer Netherlands
Erschienen in
Cellulose / Ausgabe 11/2019
Print ISSN: 0969-0239
Elektronische ISSN: 1572-882X
DOI
https://doi.org/10.1007/s10570-019-02572-0

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