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Colloid and Polymer Science
Erschienen in: Colloid and Polymer Science 5/2014

01.05.2014 | Original Contribution

Structural insights on nanoparticles containing gadolinium complexes as potential theranostic

verfasst von: Antonella Accardo, Paola Ringhieri, Noemi Szekely, Vitaly Pipich, Alessandra Luchini, Luigi Paduano, Diego Tesauro

Erschienen in: Colloid and Polymer Science | Ausgabe 5/2014

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Abstract

Nanostructures are gaining interest in drug release applications. Amphiphilic molecules can give, in water solution, a variety of nanostructures as well as thermodynamically stable mesophases three-dimensional inverse cubic structures. These mesophases are attractive candidates for biomedical applications containing extensive water channel networks and could act as very efficient delivery systems of drugs or contrast agents. In order to discover, optimize, and develop these systems, we have performed a deep physicochemical characterization by dynamic light scattering and small-angle neutron scattering of nanoparticles of monoolein (MO) and Pluronic PF127, containing different amounts (1, 5, 10, and 20 %) of the synthetic amphiphilic gadolinium complex (C18)2DTPA(Gd). Nanoparticle size is found in the 70–400 nm range for all investigated systems; the morphology of the aggregates is driven by the main constituents MO/PF127 and is a mixture of multilayer vesicles and bicontinuous aggregates. Nanostructures are also able to encapsulate doxorubicin (drug-loading content between 70 and 90 % for the different systems) acting as a potential theranostic for simultaneous cancer therapy and MRI visualization.
Vorheriger Artikel Micellization behavior of the ionic liquid lauryl isoquinolinium bromide in aqueous solution
Nächster Artikel Role of gas cooling time on crystalline morphology and mechanical property of the HDPE parts prepared by gas-assisted injection molding

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Metadaten
Titel
Structural insights on nanoparticles containing gadolinium complexes as potential theranostic
verfasst von
Antonella Accardo
Paola Ringhieri
Noemi Szekely
Vitaly Pipich
Alessandra Luchini
Luigi Paduano
Diego Tesauro
Publikationsdatum
01.05.2014
Verlag
Springer Berlin Heidelberg
Erschienen in
Colloid and Polymer Science / Ausgabe 5/2014
Print ISSN: 0303-402X
Elektronische ISSN: 1435-1536
DOI
https://doi.org/10.1007/s00396-013-3159-7

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