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Erschienen in:
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2014 | OriginalPaper | Buchkapitel

The Effect of Uncertainty in Vascular Wall Material Properties on Abdominal Aortic Aneurysm Wall Mechanics

verfasst von : Samarth S. Raut, Anirban Jana, Victor De Oliveira, Satish C. Muluk, Ender A. Finol

Erschienen in: Computational Biomechanics for Medicine

Verlag: Springer New York

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Abstract

Clinical management of abdominal aortic aneurysms (AAA) can benefit from patient-specific computational biomechanics-based assessment of the disease. Individual variations in shape and aortic material properties are expected to influence the assessment of AAA wall mechanics. While patient-specific geometry can be reproduced using medical images, the accurate individual and regionally varying tissue material property estimation is currently not feasible. This work addresses the relative uncertainties arising from variations in AAA material properties and its effect on the ensuing wall mechanics. Computational simulations were performed with five different isotropic material models based on an ex-vivo AAA wall material characterization and a subject population sample of 28 individuals. Care was taken to exclude the compounding effects of variations in all other geometric and biomechanical factors. To this end, the spatial maxima of the principal stress (σ max), principal strain (ε max), strain-energy density (ψ max), and displacement (δ max) were calculated for the diameter-matched cohort of 28 geometries for each of the five different constitutive materials. This led to 140 quasi-static simulations, the results of which were assessed on the basis of intra-patient (effect of material constants) and inter-patient (effect of individual AAA shape) differences using statistical averages, standard deviations, and Box and Whisker plots. Mean percentage variations for σ max, ε max, ψ max, and δ max for the intra-patient analysis were 1.5, 7.1, 8.0, and 6.1, respectively, whereas for the inter-patient analysis these were 11.1, 4.5, 15.3, and 12.9, respectively. Changes in the material constants of an isotropic constitutive model for the AAA wall have a negligible influence on peak wall stress. Hence, this study endorses the use of population-averaged material properties for the purpose of estimating peak wall stress, strain-energy density, and wall displacement. Conversely, strain is more dependent on the material constant variation than on the differences in AAA shape in a diameter-matched population cohort.

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Nächstes Kapitel Computer Simulation of Fracture Fixation Using Extramedullary Devices: An Appraisal
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Metadaten
Titel
The Effect of Uncertainty in Vascular Wall Material Properties on Abdominal Aortic Aneurysm Wall Mechanics
verfasst von
Samarth S. Raut
Anirban Jana
Victor De Oliveira
Satish C. Muluk
Ender A. Finol
Copyright-Jahr
2014
Verlag
Springer New York
Buch
Computational Biomechanics for Medicine

Print ISBN: 978-1-4939-0744-1

Electronic ISBN: 978-1-4939-0745-8

Copyright-Jahr: 2014

DOI
https://doi.org/10.1007/978-1-4939-0745-8_6

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