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Erschienen in: Empirical Economics 4/2023

29.03.2023

The effects of screening for gestational diabetes

verfasst von: Krista Riukula

Erschienen in: Empirical Economics | Ausgabe 4/2023

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Abstract

I estimate the effects of screening “low-risk” women for gestational diabetes using a regression discontinuity design and exploiting exogenous variation in testing at the overweight threshold of the body mass index in Finland. I find that screening low-risk mothers just above the overweight threshold increases the number of mothers diagnosed with gestational diabetes. There is a 1.5 percentage point, or 27%, increase in the probability of being diagnosed with gestational diabetes at the threshold, which translates into a 10.7 percentage point local average treatment effect given the 14.0 percentage point jump in the screening rates. The estimates on the effect on insulin treatment are, however, small and imprecise, suggesting that screening low-risk mothers did not result in diagnoses needing insulin treatment. The cost estimates in the existing literature suggest that the policy is cost-effective. The results also suggest that universal screening could decrease health disparities between mothers with low and high levels of education, given that gestational diabetes is treated if diagnosed. The effect on the probability of having an abnormal test result is over twice as great for the less educated mothers compared to the more educated mothers. Large effects of around 10–20% on adverse birth outcomes (low birth weight, macrosomia, metabolic testing, and C-section) can be ruled out.

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Fußnoten
1
Gestational diabetes used from here on. The American Diabetes Association defines gestational diabetes as follows: “any degree of glucose intolerance with onset or first recognized during pregnancy. The definition applies regardless of whether insulin or only diet modification is used for treatment or whether the condition persists after pregnancy. It does not exclude the possibility that unrecognized glucose intolerance may have antedated or begun concomitantly with the pregnancy.”
 
2
In Finland, the main rule is that all pregnant women should be screened for gestational diabetes with the oral glucose tolerance test; the few exceptions to this rule are presented in this paper.
 
3
That is, low-risk for developing gestational diabetes.
 
4
The Current Care Guidelines (Käypä hoito) are national, independent, evidence-based clinical practice guidelines that cover important issues related to Finnish health, medical treatment and prevention of disease. The guidelines are intended as a basis for treatment decisions and can be used by physicians, health care professionals and citizens. They were developed by the Finnish Medical Society Duodecim in association with various medical specialist societies.
 
5
When blood glucose levels in the body are too high (> 10 mmol/L), excess glucose can end up in the urine which can indicate gestational diabetes. Urine screening is conducted on all visits, even if the mother has tested negative for gestational diabetes with the OGTT.
 
6
In the analysis, I look at all instances of the OGTT regardless of the gestational week it was conducted. The data lack information on the week in which the test was conducted.
 
7
The cost of the test is from Terveystalo’s, a Finnish private health clinic, laboratory price list in 2015, the last year of the study period.
 
8
A descriptive population-based register study was conducted in Finland comparing women giving birth before the new guidelines were introduced in 2006 to women giving birth in 2010 after the new guidelines were implemented (Koivunen et al. 2015). The results suggest that the change in guidelines from a risk factor-driven approach to a comprehensive policy led to a significant increase—from 9.1% to 11.3%—in the prevalence of gestational diabetes, which was due to the increased number of mothers who could be treated with diet. Both the proportion and total number of insulin-treated women decreased significantly from 21.8% to 13.3%, suggesting that wider screening did not perform better in diagnosing women needing insulin treatment.
 
9
BMI or Quetelet index is a measure of relative size based on the mass and height of an individual; it is body mass divided by the square of height and always reported in \(kg/m^{2}\). A BMI from 18.5 to 25 may indicate optimal weight, while a BMI under 18.5 is considered underweight, and a BMI of over 25 is considered overweight. A person with a BMI of 30 or greater is considered obese.
 
10
The BMI is usually checked from a chart, where the y-axis represents the height of the person and the x-axis the weight. For example, a person who weighs 62 kg and is 158 cm tall would have a BMI of 25 according to the chart, while her actual BMI is 24.8 (62/(1.58*1.58) according to the formula. Hence, according to the chart, she is overweight, but according to the BMI formula, she is not. Similarly, if she weighed 61.5 kg, her weight would be rounded to 62, and hence, her BMI would be 25 according to the chart and 24.6 according to the formula.
 
11
16.7% (10.7 + 6) prevalence of positive test results for those who were screened due to crossing the overweight threshold versus 19% for those who were screened just under the threshold and are at risk.
 
12
The one-hour oral glucose challenge test (GCT) is a screening test for gestational diabetes that measures serum glucose concentration one hour after a 50 g oral glucose drink.
 
13
Estimated sample sizes for a two-sample proportions test (Pearson’s chi-squared test.)
 
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Metadaten
Titel
The effects of screening for gestational diabetes
verfasst von
Krista Riukula
Publikationsdatum
29.03.2023
Verlag
Springer Berlin Heidelberg
Erschienen in
Empirical Economics / Ausgabe 4/2023
Print ISSN: 0377-7332
Elektronische ISSN: 1435-8921
DOI
https://doi.org/10.1007/s00181-023-02397-8

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