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Colloid and Polymer Science

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27.09.2016 | Original Contribution

The interaction between poly(ε-caprolactone) copolymers containing sulfobetaines and proteins

verfasst von: Aijing Lu, Chenglong Li, Zhengzhong Wu, Xianglin Luo

Erschienen in: Colloid and Polymer Science | Ausgabe 12/2016

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Abstract

Copolymers of poly(ε-caprolactone) containing zwitterionic sulfobetaine may be used as biomedical materials. The interaction of these materials with proteins is rarely reported. In this study, amphiphilic copolymers PCL₂₀-PDEAS₆, PCL₂₀-PEG200-PDEAS₆, and PCL₂₀-PEG400-PDEAS₆, which contained poly{N-[2-(methacryloyloxy)ethyl]-N,N-diethyl-N-(3-sulfopropyl)-ammonium} (PDEAS), were designed and synthesized in order to explore interaction of these materials and their micelles with proteins. The structure of the copolymers was confirmed by ¹H-NMR, Fourier transform infrared spectroscopy (FTIR), and element analysis (EA). The copolymers could form either films or micelles. The adsorption of bovine serum albumin (BSA) and fibrinogen (Fg) on the copolymer films and their micelles was studied. The results showed that BSA adsorbed on the films presented different tendencies from their micelle formulation. The protein adsorption may be related to the hydration in the shell of the micelles and the electrostatic interaction between the charges of zwitterion and the protein. The reason for the different amounts of protein adsorption between film and micelle formulation is the difference of molecular chain arrangement and charge distribution of PCLDEAS copolymer.

Vorheriger Artikel PANI-derived polymer/Al2O3 nanocomposites: synthesis, characterization, and electrochemical studies

Nächster Artikel Temperature-driven volume phase transition of a single stimuli-responsive microgel particle using optical tweezers

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Sakata S, Inoue Y, Ishihara K (2015) Molecular interaction forces generated during protein adsorption to well-defined polymer brush surfaces. Langmuir: ACS J Surf Colloids 31(10):3108–14. doi:10.1021/acs.langmuir.5b00351 CrossRef

Hayward JA, Chapman D (1984) Biomembrane surfaces as models for polymer design: the potential for haemocompatibility. Biomaterials 5(3):135–42. doi:10.1016/0142-9612(84)90047-4 CrossRef

Sheng Y, Liu C, Yuan Y, Tao X, Yang F, Shan X et al (2009) Long-circulating polymeric nanoparticles bearing a combinatorial coating of PEG and water-soluble chitosan. Biomaterials 30(12):2340–8. doi:10.1016/j.biomaterials.2008.12.070 CrossRef

Vonarbourg A, Passirani C, Saulnier P, Benoit JP (2006) Parameters influencing the stealthiness of colloidal drug delivery systems. Biomaterials 27(24):4356–73. doi:10.1016/j.biomaterials.2006.03.039 CrossRef

Ruenraroengsak P, Cook JM, Florence AT (2010) Nanosystem drug targeting: Facing up to complex realities. J Control Release: Off J Control Release Soc 141(3):265–76. doi:10.1016/j.jconrel.2009.10.032 CrossRef

Salvati A, Pitek AS, Monopoli MP, Prapainop K, Bombelli FB, Hristov DR et al (2013) Transferrin-functionalized nanoparticles lose their targeting capabilities when a biomolecule corona adsorbs on the surface. Nat Nanotechnol 8(2):137–43. doi:10.1038/nnano.2012.237 CrossRef

Ma H, Hyun J, Stiller P, Chilkoti A (2004) “Non-Fouling” oligo(ethylene glycol)-functionalized polymer brushes synthesized by surface-initiated atom transfer radical polymerization. Adv Mater 16(4):338–41. doi:10.1002/adma.200305830 CrossRef

Moghimi SM, Hunter AC, Murray JC (2001) Long-circulating and target-specific nanoparticles: theory to practice. Pharmacol Rev 53(2):283–318

Yao J, Wu H, Ruan Y, Guan J, Wang A, Li H (2011) “Reservoir” and “barrier” effects of ABC block copolymer micelle in hydroxyapatite mineralization control. Polymer 52(3):793–803. doi:10.1016/j.polymer.2010.12.017 CrossRef

10.

Stolnik S, Illum L, Davis SS (2012) Long circulating microparticulate drug carriers. Adv Drug Deliv Rev 64:290–301. doi:10.1016/j.addr.2012.09.029 CrossRef

11.

Xiao K, Luo J, Li Y, Lee JS, Fung G, Lam KS (2011) PEG-oligocholic acid telodendrimer micelles for the targeted delivery of doxorubicin to B-cell lymphoma. J Control Release: Off J Control Release Soc 155(2):272–81. doi:10.1016/j.jconrel.2011.07.018 CrossRef

12.

Peng Q, Wei XQ, Shao XR, Zhang T, Zhang S, Fu N et al (2014) Nanocomplex based on biocompatible phospholipids and albumin for long-circulation applications. ACS Appl Mater Interfaces 6(16):13730–7. doi:10.1021/am503179a CrossRef

13.

Amoozgar Z, Yeo Y (2012) Recent advances in stealth coating of nanoparticle drug delivery systems. Wiley interdiscip Rev Nanomed Nanobiotechnol 4(2):219–33. doi:10.1002/wnan.1157 CrossRef

14.

Knop K, Hoogenboom R, Fischer D, Schubert US (2010) Poly(ethylene glycol) in drug delivery: pros and cons as well as potential alternatives. Angew Chem 49(36):6288–308. doi:10.1002/anie.200902672 CrossRef

15.

Zhang Z, Zhang M, Chen S, Horbett TA, Ratner BD, Jiang S (2008) Blood compatibility of surfaces with superlow protein adsorption. Biomaterials 29(32):4285–91. doi:10.1016/j.biomaterials.2008.07.039 CrossRef

16.

Lalani R, Liu L (2011) Synthesis, characterization, and electrospinning of zwitterionic poly(sulfobetaine methacrylate). Polymer 52(23):5344–54. doi:10.1016/j.polymer.2011.09.015 CrossRef

17.

Zhao C, Zhao J, Li X, Wu J, Chen S, Chen Q et al (2013) Probing structure–antifouling activity relationships of polyacrylamides and polyacrylates. Biomaterials 34(20):4714–24. doi:10.1016/j.biomaterials.2013.03.028 CrossRef

18.

Ladd J, Zhang Z, Chen S, Hower JC, Jiang S (2008) Zwitterionic polymers exhibiting high resistance to nonspecific protein adsorption from human serum and plasma. Biomacromolecules 9(5):1357–61. doi:10.1021/bm701301s CrossRef

19.

Chang Y, Chen WY, Yandi W, Shih YJ, Chu WL, Liu YL et al (2009) Dual-thermo responsive phase behavior of blood compatible zwitterionic copolymers containing nonionic poly(N-isopropyl acrylamide). Biomacromolecules 10(8):2092–100. doi:10.1021/bm900208u CrossRef

20.

Chang Y, Chang WJ, Shih YJ, Wei TC, Hsiue GH (2011) Zwitterionic sulfobetaine-grafted poly (vinylidene fluoride) membrane with highly effective blood compatibility via atmospheric plasma-induced surface copolymerization. ACS Appl Mater Interfaces 3(4):1228–37. doi:10.1021/am200055k CrossRef

21.

Zhang Z, Chen S, Jiang S (2006) Dual-functional biomimetic materials: nonfouling poly(carboxybetaine) with active functional groups for protein immobilization. Biomacromolecules 7(12):3311–5. doi:10.1021/bm060750m CrossRef

22.

Yuan J, Mao C, Zhou J, Shen J, Lin SC, Zhu W et al (2003) Chemical grafting of sulfobetaine onto poly(ether urethane) surface for improving blood compatibility. Polym Int 52(12):1869–75. doi:10.1002/pi.1277 CrossRef

23.

Jiang H, Wang XB, Li CY, Li JS, Xu FJ, Mao C et al (2011) Improvement of hemocompatibility of polycaprolactone film surfaces with zwitterionic polymer brushes. Langmuir: ACS J Surf Colloids 27(18):11575–81. doi:10.1021/la202101q CrossRef

24.

Cao J, Chen YW, Wang X, Luo XL (2011) Enhancing blood compatibility of biodegradable polymers by introducing sulfobetaine. J Biomed Mater Res Part A 97(4):472–9. doi:10.1002/jbm.a.33060 CrossRef

25.

Cao J, Lu A, Li C, Cai M, Chen Y, Li S et al (2013) Effect of architecture on the micellar properties of poly (varepsilon-caprolactone) containing sulfobetaines. Colloids Surf B: Biointerfaces 112:35–41. doi:10.1016/j.colsurfb.2013.07.038 CrossRef

26.

Cao J, Xiu KM, Zhu K, Chen YW, Luo XL (2012) Copolymer nanoparticles composed of sulfobetaine and poly(epsilon-caprolactone) as novel anticancer drug carriers. J Biomed Mater Res Part A 100(8):2079–87. doi:10.1002/jbm.a.34120 CrossRef

27.

Zhai S, Ma Y, Chen Y, Li D, Cao J, Liu Y et al (2014) Synthesis of an amphiphilic block copolymer containing zwitterionic sulfobetaine as a novel pH-sensitive drug carrier. Polym Chem 5(4):1285. doi:10.1039/c3py01325a CrossRef

28.

Cao J, Zhai S, Li C, He B, Lai Y, Chen Y et al (2013) Novel pH-sensitive micelles generated by star-shape copolymers containing zwitterionic sulfobetaine for efficient cellular internalization. J Biomed Nanotechnol 9(11):1847–61. doi:10.1166/jbn.2013.1686 CrossRef

29.

Chang Y, Yandi W, Chen WY, Shih YJ, Yang CC, Chang Y et al (2010) Tunable bioadhesive copolymer hydrogels of thermoresponsive poly(N-isopropyl acrylamide) containing zwitterionic polysulfobetaine. Biomacromolecules 11(4):1101–10. doi:10.1021/bm100093g CrossRef

30.

Zhu Z, Xie C, Liu Q, Zhen X, Zheng X, Wu W et al (2011) The effect of hydrophilic chain length and iRGD on drug delivery from poly(epsilon-caprolactone)-poly(N-vinylpyrrolidone) nanoparticles. Biomaterials 32(35):9525–35. doi:10.1016/j.biomaterials.2011.08.072 CrossRef

31.

Rubatat L, Li C, Dietsch H, Nykänen A, Ruokolainen J, Mezzenga R (2008) Structure−properties relationship in proton conductive sulfonated polystyrene−polymethyl methacrylate block copolymers (sPS − PMMA). Macromolecules 41(21):8130–7. doi:10.1021/ma801543q CrossRef

32.

Leng C, Han X, Shao Q, Zhu Y, Li Y, Jiang S et al (2014) In situ probing of the surface hydration of zwitterionic polymer brushes: structural and environmental effects. J Phys Chem C 118(29):15840–5. doi:10.1021/jp504293r CrossRef

33.

Luengo-Alonso C, Torrado JJ, Ballesteros MP, Malfanti A, Bersani S, Salmaso S et al (2015) A novel performing PEG-cholane nanoformulation for amphotericin B delivery. Int J Pharm 495(1):41–51. doi:10.1016/j.ijpharm.2015.08.070 CrossRef

34.

Seo JH, Matsuno R, Konno T, Takai M, Ishihara K (2008) Surface tethering of phosphorylcholine groups onto poly(dimethylsiloxane) through swelling—deswelling methods with phospholipids moiety containing ABA-type block copolymers. Biomaterials 29(10):1367–76. doi:10.1016/j.biomaterials.2007.11.039 CrossRef

35.

Lee JH, Ju YM, Kim DM (2000) Platelet adhesion onto segmented polyurethane film surfaces modified by addition and crosslinking of PEO-containing block copolymers. Biomaterials 21:683–91CrossRef

36.

Liu P-S, Chen Q, Wu S-S, Shen J, Lin S-C (2010) Surface modification of cellulose membranes with zwitterionic polymers for resistance to protein adsorption and platelet adhesion. J Membr Sci 350(1–2):387–94. doi:10.1016/j.memsci.2010.01.015 CrossRef

37.

Gombotz WR, Wang GH, Horbett TA, Hoffman AS (1991) Protein adsorption to poly(ethylene oxide) surfaces. J Biomed Mater Res 25(12):1547–62. doi:10.1002/jbm.820251211 CrossRef

38.

Zhang Z, Chen S, Chang Y, Jiang S (2006) Surface grafted sulfobetaine polymers via atom transfer radical polymerization as superlow fouling coatings. J Phys Chem B 110(22):10799–804. doi:10.1021/jp057266i CrossRef

39.

Ishihara K, Nomura H, Mihara T, Kurita K, Iwasaki Y, Nakabayashi N (1998) Why do phospholipid polymers reduce protein adsorption? J Biomed Mater Res 39(2):323–30. doi:10.1002/(sici)1097-4636(199802)39:2<323::aid-jbm21>3.0.co;2-c CrossRef

40.

Song W, Chen H (2007) Protein adsorption on materials surfaces with nano-topography. Chin Sci Bull 52(23):3169–73. doi:10.1007/s11434-007-0504-6 CrossRef

Titel: The interaction between poly(ε-caprolactone) copolymers containing sulfobetaines and proteins
verfasst von: Aijing Lu
Chenglong Li
Zhengzhong Wu
Xianglin Luo
Publikationsdatum: 27.09.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: Colloid and Polymer Science / Ausgabe 12/2016
Print ISSN: 0303-402X
Elektronische ISSN: 1435-1536
DOI: https://doi.org/10.1007/s00396-016-3942-3

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