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Cognitive Processing
Erschienen in: Cognitive Processing 2/2012

01.05.2012 | Research Report

Toward operational architectonics of consciousness: basic evidence from patients with severe cerebral injuries

verfasst von: Andrew A. Fingelkurts, Alexander A. Fingelkurts, Sergio Bagnato, Cristina Boccagni, Giuseppe Galardi

Erschienen in: Cognitive Processing | Ausgabe 2/2012

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Abstract

Although several studies propose that the integrity of neuronal assemblies may underlie a phenomenon referred to as awareness, none of the known studies have explicitly investigated dynamics and functional interactions among neuronal assemblies as a function of consciousness expression. In order to address this question, EEG operational architectonics analysis (Fingelkurts and Fingelkurts 2001, 2008) was conducted in patients in minimally conscious (MCS) and vegetative states (VS) to study the dynamics of neuronal assemblies and operational synchrony among them as a function of consciousness expression. We found that in minimally conscious patients and especially in vegetative patients neuronal assemblies got smaller, their life span shortened and they became highly unstable. Furthermore, we demonstrated that the extent/volume and strength of operational synchrony among neuronal assemblies was smallest or even absent in VS patients, intermediate in MCS patients, and highest in healthy fully conscious subjects. All findings were similarly observed in EEG alpha as well as beta1 and beta2 frequency oscillations. The presented results support the basic tenets of operational architectonics theory of brain–mind functioning and suggest that EEG operational architectonics analysis may provide an objective and accurate means of assessing signs of (un)consciousness in patients with severe brain injuries. Therefore, this methodological approach may complement the existing “gold standard” of behavioral assessment of this population of challenging patients and inform the diagnostic and treatment decision-making processes.
Vorheriger Artikel The novel object recognition memory: neurobiology, test procedure, and its modifications
Nächster Artikel Microswitch technology and contingent stimulation to promote adaptive engagement in persons with minimally conscious state: a case evaluation

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Fußnoten
1
One additional advantage of such a model is the fact that patients in a minimally conscious state and patients in a vegetative state (fully unconscious) have no significant pathological distinctions as it has been shown in histopathological studies (Jennett et al. 2001). This is important because possible differences in states could not be attributed to differences in pathophysiology. At the same time, even in patients with severe brain injuries, consciousness could not be efficiently dissociated from multiple cognitive functions which always “melt” with subjective experiences (Fig. 3). For example, it was shown that the more complex and elaborate forms of conscious awareness found in adult humans are also likely to be associated with greater cognitive capacities (Kinsbourne 2005). This is in fact a limitation of the model, since consciousness is thought to be independent of specific cognitive functions (for a discussion see Revonsuo 2006). For example, consciousness can be dissociated from episodic memory (in the case of amnesic patients, who lack memory encoding, but are still conscious of themselves and their environment) or from language (in aphasic patients, who retain a preserved perception of their environment), or even from the sensorimotor processing (during dreaming, where the subject has vivid experiences despite the absence of sensorimotor interactions with the external world) (for an overview, see Tononi and Laureys 2008).
 
2
Curiously enough, the robustness of consciousness level gradation is accepted uncritically in clinical practice. As claimed by Hudetz (2010), although a continuum of states—from wakefulness through drowsiness to deep sleep or anesthesia—seems intuitive, such a one-dimensional model of states of consciousness is obviously an oversimplification.
 
3
The strength of operational synchrony for the same groups of patients within default mode network (DMN) that has been related to self-consciousness is reported in another paper (Fingelkurts et al. submitted).
 
4
Different EEG oscillations appear to be related to the timing of different neuronal assemblies (activated network parts), which are associated with different types of operations (von der Malsburg 1999; Varela 1995; Buzsáki 2004, 2006). The general assumption is that the functional interplay between units of the same assembly or between different assemblies is based on a coordinated timing that is enabled by oscillations (for a discussion see Fingelkurts et al. 2010).
 
5
As our data presented elsewhere (Fingelkurts et al. submitted) have shown, the strength of operational synchrony within DMN follows the same direction: NORM ≥ MCS > VS. It has been proposed recently that DMN is responsible for the self-consciousness awareness (for review see Fingelkurts and Fingelkurts 2011; Northoff et al. 2011).
 
6
Human children younger than 3 years are unable to produce higher cognitive processes, full-fledged consciousness, and do not show alpha activity (Başar and Güntekin 2009). At the same time, the brain in such children shows only sparse and weak connections (Thatcher et al. 1986, 1987).
 
7
The beta band (along with the alpha band) evolutionary appeared only in primates (including humans), who are geared with a cortical mantle (Knyazev 2007). These frequency bands reach the strongest expressions in humans who are at the same time the carriers of a full-fledged consciousness of self and environment (Knyazev and Slobodskaya 2003). The theta oscillations predominate within the brain of a lower mammals (Klimesch 1999), while the reptile brain oscillates mostly in the delta range (Gaztelu et al. 1991). Neither of these species could be assigned with a phenomenal consciousness.
 
Literatur
Aertsen AMHJ, Gerstein GL, Habib MK, Palm G, Adrian ED (1989) Dynamics of neuronal ring correlation: modulation of “effective connectivity”. J Neurophysiol 61:900–917PubMed
Aftanas LI, Pavlov SV, Reva NV, Varlamov AA (2003) Trait anxiety impact on the EEG theta band power changes during appraisal of threatening and pleasant visual stimuli. Int J Psychophysiol 50:205–212PubMedCrossRef
Alkire MT, Haier RJ, Fallon JH (2000) Toward a unified theory of narcosis: brain imaging evidence for a thalamocortical switch as the neurophysiologic basis of anesthetic-induced unconsciousness. Conscious Cogn 9:370–386PubMedCrossRef
ANA Committee on Ethical Affairs (1993) Persistent vegetative state: report of the American neurological association committee on ethical affairs. Ann Neurol 33:386–390CrossRef
Andrews K (2004) Medical decision making in the vegetative state: withdrawal of nutrition and hydration. Neuro Rehabil 19:299–304
Andrews K, Murphy L, Munday R, Littlewood C (1996) Misdiagnosis of the vegetative state: retrospective study in a rehabilitation unit. BMJ 313:13–16PubMedCrossRef
Baars BJ (1988) A cognitive theory of consciousness. Cambridge University Press, Cambridge
Baars BJ (2002) The conscious access hypothesis: origins and recent evidence. Trends Cogn Sci 6:47–52PubMedCrossRef
Babiloni C, Vecchio F, Miriello M, Romani GL, Rossini PM (2006) Visuo-spatial consciousness and parieto-occipital areas: a high-resolution EEG study. Cereb Cortex 16:37–46PubMedCrossRef
Babiloni C, Ferri R, Binetti G, Vecchio F, Frisoni GB, Lanuzza B et al (2009) Directionality of EEG synchronization in Alzheimer’s disease subjects. Neurobiol Aging 30:93–102PubMedCrossRef
Bagnato S, Boccagni C, Prestandrea C, Sant’Angelo A, Castiglione A, Galardi G (2010) Prognostic value of standard EEG in traumatic and non-traumatic disorders of consciousness following coma. Clin Neurophysiol 121:274–280PubMedCrossRef
Ball T, Demandt E, Mutschler I, Neitzel E, Mehring C, Vogt K, Aertsen A, Schulze-Bonhage A (2008) Movement related activity in the high gamma range of the human EEG. NeuroImage 41:302–310PubMedCrossRef
Başar E, Güntekin B (2009) Darwin’s evolution theory, brain oscillations, and complex brain function in a new “Cartesian view”. Int J Psychophysiol 71:2–8PubMedCrossRef
Başar EC, Başar EC, Karakas S, Schurmann M (2000) Brain oscillations in perception and memory. Int J Psychophysiol 35:95–124PubMedCrossRef
Başar E, Başar-Eroglu C, Karakas S, Schurmann M (2001) Gamma, alpha, delta, and theta oscillations govern cognitive processes. Int J Psychophysiol 39:241–248PubMedCrossRef
Blumenfeld H (2008) Epilepsy and consciousness. In: Laureys S, Tononi G (eds) The neurology of consciousness. Elsevier Academic Press, Oxford, pp 247–260
Boccagni C, Bagnato S, Sant’Angelo A, Prestandrea C, Galardi G (2011) Usefulness of standard EEG in predicting the outcome of patients with disorders of consciousness following anoxic coma. J Clin Neurophysiol (in press)
Boly M, Faymonville ME, Peigneux P, Lambermont B, Damas P, Del Fiore G et al (2004) Auditory processing in severely brain injured patients: differences between the minimally conscious state and the persistent vegetative state. Arch Neurol 61:233–238PubMedCrossRef
Brazdil M, Rektor I, Daniel P, Dufek M, Jurak P (2001) Intracerebral event-related potentials to subthreshold target stimuli. Clin Neurophysiol 112:650–661PubMedCrossRef
Bressler SL (2002) Understanding cognition through large-scale cortical networks. Curr Dir Psychol Sci 11:58–61CrossRef
Bressler SL, Kelso JAS (2001) Cortical coordination dynamics and cognition. Trends Cogn Sci 5:26–36PubMedCrossRef
Bressler SL, McIntosh AR (2007) The role of neural context in large-scale neurocognitive network operations. In: Jirsa VK, McIntosh AR (eds) Handbook of brain connectivity. Springer, pp, pp 403–419CrossRef
Bressler SL, Tognoli E (2006) Operational principles of neurocognitive networks. Int J Psychophysiol 60:139–148PubMedCrossRef
Brett M, Leff AP, Rorden C, Ashburner J (2001) Spatial normalization of brain images with focal lesions uding cost function masking. NeuroImage 14:486–500PubMedCrossRef
Buzsáki G (2006) Rhythms of the brain. Oxford University Press, OxfordCrossRef
Buzsáki G, Draguhn A (2004) Neuronal oscillations in cortical networks. Science 304:1926–1929PubMedCrossRef
Cauda F, Micon BM, Sacco K, Duca S, D’Agata F, Geminiani G, Canavero S (2009) Disrupted intrinsic functional connectivity in the vegetative state. J Neurol Neurosurg Psychiatry 80:429–431PubMedCrossRef
Cavanna AE, Monaco F (2009) Brain mechanisms of altered conscious states during epileptic seizures. Nat Rev Neurol 5:267–276PubMedCrossRef
Childs NL, Mercer WN, Childs HW (1993) Accuracy of diagnosis of persistent vegetative state. Neurology 43:1465–1467PubMed
Coleman MR, Rodd JM, Davis MH, Johnsrude IS, Menon DK et al (2007) Do vegetative patients retain aspects of language comprehension? Evidence from fMRI. Brain 130:2494–2507PubMedCrossRef
Cologan V, Schabus M, Ledoux D, Moonen G, Maquet P, Laureys S (2010) Sleep in disorders of consciousness. Sleep Med Rev 14:97–105PubMedCrossRef
Davey MP, Victor JD, Schiff ND (2000) Power spectra and coherence in the EEG of a vegetative patient with severe asymmetric brain damage. Clin Neurophysiol 111:1949–1954PubMedCrossRef
de Jong B, Willemsen AT, Paans AM (1997) Regional cerebral blood flow changes related to affective speech presentation in persistent vegetative state. Clin Neurol Neurosurg 99:213–216PubMedCrossRef
Dehaene S, Changeux J-P, Naccache L, Sackur J, Sergent C (2006) Conscious, preconscious, and subliminal processing: a testable taxonomy. Trends Cogn Sci 10:204–211PubMedCrossRef
Edelman GM, Tononi G (2000) A universe of consciousness: how matter becomes imagination. Basic Books, New York
Engel AK, Singer W (2001) Temporal binding and the neural correlates of sensory awareness. Trends Cogn Sci 5:16–25PubMedCrossRef
Faran S, Vatine JJ, Lazary A, Ohry F, Birbaumer N, Kotchoubey B (2006) Late recovery from permanent traumatic vegetative state heralded by event-related potentials. J Neurol Neurosurg Psychiatry 77:998–1000PubMedCrossRef
Faulkner EA (1969) Introduction to the theory of linear systems. Chapman & Hall
Feinberg TE (2000) The nested hierarchy of consciousness: a neurobiological solution to the problem of mental unity. Neurocase 6:75–81CrossRef
Ferree TC, Luu P, Russell GS, Tucker DM (2001) Scalp electrode impedance, infection risk, and EEG data quality. Clin Neurophysiol 112:536–544PubMedCrossRef
Fingelkurts AnA (1998) Time-spatial organization of the human EEG segmental structure. PhD dissertation. MSU press, Moscow, p 401 (in Russian)
Fingelkurts AnA, Fingelkurts AlA (2001) Operational architectonics of the human brain biopotential field: towards solving the mind-brain problem. Brain Mind 2:261–296
Fingelkurts AnA, Fingelkurts AlA (2003) Operational architectonics of perception and cognition: a principle of self-organized metastable brain states (invited full-text contribution). VI Parmenides workshop, Institute of Medical Psychology, Elba, Italy, 5–10, April
Fingelkurts AnA, Fingelkurts AlA (2004) Making complexity simpler: multivariability and metastability in the Brain. Int J Neurosci 114:843–862
Fingelkurts AnA, Fingelkurts AlA (2005) Mapping of the brain operational architectonics. In: Chen FJ (ed) Focus on brain mapping research, Chap 2. Nova Science Publishers Inc, Commack, pp 59–98
Fingelkurts AnA, Fingelkurts AlA (2006) Timing in cognition and EEG brain dynamics: discreteness versus continuity. Cogn Process 7:135–162
Fingelkurts AnA, Fingelkurts AlA (2008) Brain-mind operational architectonics imaging: technical and methodological aspects. Open Neuroimag J 2:73–93
Fingelkurts AnA, Fingelkurts AlA (2010a) Alpha rhythm operational architectonics in the continuum of normal and pathological brain states: current state of research. Int J Psychophysiol 76:93–106
Fingelkurts AlA, Fingelkurts AnA (2010b) Short-term EEG spectral pattern as a single event in EEG phenomenology. Open Neuroimag J 4:130–156
Fingelkurts AnA, Fingelkurts AlA (2011) Persistent operational synchrony within brain default-mode network and self-processing operations in healthy subjects. Brain Cog 75:79–90
Fingelkurts AnA, Fingelkurts AlA, Krause CM, Möttönen R, Sams M (2003) Cortical operational synchrony during audio-visual speech integration. Brain Lang 85:297–312
Fingelkurts AnA, Fingelkurts AlA, Kivisaari R, Pekkonen E, Ilmoniemi RJ, Kähkönen SA (2004) Local and remote functional connectivity of neocortex under the inhibition influence. NeuroImage 22:1390–1406
Fingelkurts AlA, Fingelkurts AnA, Krause CM (2007) Composition of brain oscillations and their functions in the maintenance of auditory, visual and audio-visual speech percepts: an exploratory study. Cogn Process 8:183–199
Fingelkurts AnA, Fingelkurts AlA, Neves CFH (2009) Phenomenological architecture of a mind and operational architectonics of the brain: the unified metastable continuum. J New Math Natural Comput 5:221–244
Fingelkurts AnA, Fingelkurts AlA, Neves CFH (2010) Natural world physical, brain operational, and mind phenomenal space–time. Phys Life Rev 7:195–249
Flohr H (1995) An information processing theory of anaesthesia. Neuropsychologia 9:1169–1180CrossRef
Freeman WJ (1975) Mass action in the nervous system. Academic Press, New York
Freeman WJ (1992) Tutorial on neurobiology: from single neurons to brain chaos. Int J Bifurcat Chaos 2:451–482CrossRef
Freeman WJ (2003) The wave packet: an action potential for the 21st century. J Integr Neurosci 2:3–30PubMedCrossRef
Freeman WJ (2007) Indirect biological measures of consciousness from field studies of brains as dynamical systems. Neural Netw 20:1021–1031PubMedCrossRef
Gaztelu JM, Garcia-Austt E, Bullock TH (1991) Electrocorticograms of hippocampal and dorsal cortex of two reptiles: comparison with possible mammalian homologs. Brain Behav Evol 37:144–160PubMedCrossRef
Giacino JT, Ashwal S, Childs N, Cranford R, Jennett B, Katz DI, Kelly JP et al (2002) The minimally conscious state. Definition and diagnostic criteria. Neurology 58:349–353PubMed
Giacino JT, Kalmar K, Whyte J (2004) The JFK coma recovery scale-revised: measurement characteristics and diagnostic utility. Arch Phys Med Rehabil 85:2020–2029PubMedCrossRef
Goldfine AM, Kobylarz EJ, Hudson AE, Giacino JT, Hirsch J, Schiff ND (2005) Quantitative electroencephalography in a patient emerged from the minimally conscious state after 19 years. Program no 16.10, abstract viewer/itinerary planner, Society for Neuroscience
Gouvier WD, Blanton PD, LaPorte KK, Nepomuceno C (1987) Reliability and validity of the disability rating scale and the levels of cognitive functioning scale in monitoring recovery from severe head injury. Arch Phys Med Rehabil 68:94–97PubMed
Hagemann D, Naumann E, Thayer JF (2001) The quest for the EEG reference revisited: a glance from brain asymmetry research. Psychophysiology 38:847–857PubMedCrossRef
Hari R, Salmelin R (1997) Human cortical oscillations: a neuromagnetic view through the skull. Trends Neurosci 20:44–49PubMedCrossRef
Hipp JF, Engel AK, Siegel M (2011) Oscillatory synchronization in large-scale cortical networks predicts perception. Neuron 69:387–396PubMedCrossRef
Holzinger B, LaBerge S, Levitan L (2006) Psychophysiological correlates of lucid dreaming. Dreaming 16:88–95CrossRef
Hudetz A (2010) Cortical disintegration mechanism of anesthetic-induced unconsciousness. In: Hudetz A, Pearce R (eds) Suppressing the mind: contemporary clinical neuroscience. Humana Press, pp, pp 99–125
Ingber L (1995) Statistical mechanics of multiple scales of neocortical interactions. In: Nunez PL (ed) Neocortical dynamics and human EEG rhythms. Oxford University Press, New York, pp 628–681
Jennett B, Snoek J, Bond MR, Brooks N (1981) Disability after severe brain injury: observations on the use of the Glasgow outcome scale. J Neurol Neurosurg Psychiatry 44:285–293PubMedCrossRef
Jennett B, Adams JH, Murray LS, Graham DI (2001) Neuropathology in vegetative and severely disabled patients after head injury. Neurology 56:486–490PubMed
John ER (2001) A field theory of consciousness. Conscious Cogn 9–10:184–213CrossRef
John ER, Prichep LS (2005) The anesthetic cascade: a theory of how anesthesia suppresses consciousness. Anesthesiology 102:447–471PubMedCrossRef
John ER, Easton P, Isenhart R (1997) Consciousness and cognition may be mediated by multiple independent coherent ensembles. Conscious Cogn 6:3–39PubMedCrossRef
Juengling FD, Kassubek J, Huppertz HJ, Krause T, Els T (2005) Separating functional and structural damage in persistent vegetative state using combined voxel-based analysis of 3-D MRI and FDG-PET. J Neurol Sci 228:179–184PubMedCrossRef
Kaiser DA, Sterman MB (1994) Periodicity of standardized EEG spectral measures across the waking day. Presented at the 7th annual summer sleep workshop multi-site training program for basic sleep research. Lake Arrowhead, California
Kaplan AYA, Borisov SV (2003) Dynamic properties of segmental characteristics of EEG alpha activity in rest conditions and during cognitive load. Zh Vyssh Nerv Deiat im IP Pavlova (Journal of High Nervous Activity by IP Pavlov) 53:22–32 (in Russian)
Kaplan AYA, Fingelkurts AnA, Fingelkurts AlA, Borisov SV, Darkhovsky BS (2005) Nonstationary nature of the brain activity as revealed by EEG/MEG: methodological, practical and conceptual challenges. Signal Process 85:2190–2212CrossRef
Kelso JAS, Engstrøm D (2006) The complementary nature. MIT Press, Cambridge
Kelso JAS, Tognoli E (2007) Toward a complementary neuroscience: metastable coordination dynamics of the brain. In: Kozma R, Perlovsky L (eds) Neurodinamics of higher-level cognition and consciousness. Springer, Heidelberg, pp 39–59CrossRef
Kinney HC, Samuels MA (1994) Neuropathology of the persistent vegetative state: a review. J Neuropathol Exp Neurol 53:548–558PubMedCrossRef
Kinsbourne M (2005) A continuum of self-consciousness that emerges in phylogeny and ontogeny. In: Terrace HS, Metcalfe J (eds) The missing link in cognition: origins of self-reflective consciousness. Oxford University Press, New York, pp 142–156
Klimesch W (1996) Memory processes, brain oscillations and EEG synchronization. Int J Psychophysiol 24:61–100PubMedCrossRef
Klimesch W (1999) EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis. Brain Res Rev 29:169–195PubMedCrossRef
Klimesch W, Schack B, Sauseng P (2005) The functional significance of theta and upper alpha oscillations. Exp Psychol 52:99–108PubMed
Knyazev GG (2006) EEG correlates of personality types. Neth J Psychol 62:78–87CrossRef
Knyazev GG (2007) Motivation, emotion, and their inhibitory control mirrored in brain oscillations. Neurosci Biobehav Rev 31:377–395PubMedCrossRef
Knyazev GG, Slobodskaya HR (2003) Personality trait of behavioral inhibition is associated with oscillatory systems reciprocal relationships. Int J Psychophysiol 48:247–261PubMedCrossRef
Knyazeva MG, Fornari E, Meuli R, Maeder P (2006) Interhemispheric integration at different spatial scales: the evidence from EEG coherence and fMRI. J Neurophysiol 96:259–275PubMedCrossRef
Kobylarz EJ, Schiff ND (2004) Functional imaging of severely brain-injured patients. Progress, challenges, and limitations. Arch Neurol 61:1357–1360PubMedCrossRef
Kotchoubey B (2005) Event-related potential measures of consciousness: two equations with three unknowns. In: Laureys S (ed) Progress in brain research, vol 150. Elsevier BV, pp 427–444
Kotchoubey B, Lang S (2011) Intuitive versus theory-based assessment of consciousness: the problem of low-level consciousness. Clin Neurophysiol 122:430–432PubMedCrossRef
Kotchoubey B, Lang S, Bostanov V, Birbaumer N (2002) Is there a mind? Electrophysiology of unconscious patients. News Physiol Sci 17:38–42PubMed
Laufs H, Lengler U, Hamandi K, Kleinschmidt A, Krakow K (2006) Linking generalized spike-and-wave discharges and resting state brain activity by using EEG/fMRI in a patient with absence seizures. Epilepsia 47:444–448PubMedCrossRef
Laureys S (2005) The neural correlate of (un)awareness: lessons from the vegetative state. Trends Cogn Sci 9:556–559PubMedCrossRef
Laureys S, Goldman S, Phillips C, Van Bogaert P, Aerts J, Luxen A et al (1999) Impaired effective cortical connectivity in vegetative state: preliminary investigation using PET. NeuroImage 9:377–382PubMedCrossRef
Laureys S, Faymonville ME, Luxen A, Lamy M, Franck G, Maquet P (2000) Restoration of thalamocortical connectivity after recovery from persistent vegetative state. Lancet 355:1790–1791PubMedCrossRef
Laureys S, Antoine S, Boly M, Elincx S, Faymonville M-E, Berre J et al (2002) Brain function in the vegetative state. Acta Neurol Belg 102:177–185PubMed
Lazarev VV (2006) The relationship of theory and methodology in EEG studies of mental activity. Int J Psychophysiol 62:384–393PubMedCrossRef
Le Van Quyen M (2011) The brain web of cross-scale interactions. New Ideas Psychol 29:57–63CrossRef
Lehmann D (1984) EEG assessment of brain activity: spatial aspects, segmentation and imaging. Int J Psychophysiol 1:267–276PubMedCrossRef
Libet B (2003) Timing of conscious experience: reply to the 2002 commentaries on Libet’s findings. Conscious Cogn 12:321–331PubMedCrossRef
Livanov MN (1977) Spatial organization of cerebral processes. Wiley, New York
Majerus S, Gill-Thwaites H, Andrews K, Laureys S (2005) Behavioral evaluation of consciousness in severe brain damage. Prog Brain Res 150:397–413PubMedCrossRef
Mashour GA (2004) Consciousness unbound: toward a paradigm of general anesthesia. Anesthesiology 100:428–433PubMedCrossRef
McFadden J (2002) Synchronous firing and its influence on the brain’s electromagnetic field. Evidence for an electromagnetic field theory of consciousness. J Conscious Stud 9:23–50
Metzinger T (2003) Being no one. The self-model theory of subjectivity. MIT Press, Cambridge
Metzinger T (2007) The self-model theory of subjectivity (SMT). Scholarpedia 2:4174CrossRef
Milner AD, Goodale MA (1995) The visual brain in action. Oxford University Press, Oxford
Moritz CH, Rowley HA, Haughton VM, Swartz KR, Jones J, Badie B (2001) Functional MR imaging assessment of a non-responsive brain injured patient. Magn Reson Imaging 19:1129–1132PubMedCrossRef
Mosovich A, Tallaferro A (1954) Studies on EEG and sex function orgasm. Dis Nerv Syst 15:218–220PubMed
Mundy-Castle AC (1957) The electroencephalogram and mental activity. Electroencephalogr Clin Neurophysiol 9:643–655PubMedCrossRef
Murthy VN, Fetz EE (1992) Coherent 25–35 Hz oscillations in the sensorimotor cortex of awake behaving monkeys. Proc Natl Acad Sci USA 89:5670–5674PubMedCrossRef
Naccache L, Dehaene S (2001) Unconscious semantic priming extends to novel unseen stimuli. Cognition 80:215–229PubMedCrossRef
Neumann N, Kotchoubey B (2004) Assessment of cognitive functions in severely paralysed and severely brain-damaged patients: neuropsychological and electrophysiological methods. Brain Res Brain Res Protoc 14:25–36PubMedCrossRef
Northoff G, Qin P, Feinberg TE (2011) Brain imaging of the self–Conceptual, anatomical and methodological issues. Conscious Cogn 20:52–63PubMedCrossRef
Nunez PL (1995) Neocortical dynamics and human EEG rhythms. Oxford University Press, New York
Nunez PL (2000) Toward a quantitative description of large-scale neocortical dynamic function and EEG. Behav Brain Sci 23:371–398PubMedCrossRef
Overgaard M (2009) How can we know if patients in coma, vegetative state or minimally conscious state are conscious? In: Laureys S et al (eds) Progress in brain research, vol 177. Elsevier BV, Amsterdam, pp 11–19
Owen AM, Coleman MR, Boly M, Davis MH, Laureys S, Pickard JD (2006) Detecting awareness in the vegetative state. Science 313:1402PubMedCrossRef
Palva S, Palva JM (2007) New vistas for a-frequency band oscillations. Trends Neurosci 30(4):150–158PubMedCrossRef
Palva JM, Palva S, Kaila K (2005) Phase synchrony among neuronal oscillations in the human cortex. J Neurosci 25:3962–3972PubMedCrossRef
Panksepp J, Fuchs T, Abella Garcia V, Lesiak A (2007) Does any aspect of mind survive brain damage that typically leads to a persistent vegetative state? Ethical considerations. Philos Ethics Humanit Med 2:32PubMedCrossRef
Pare P, Collins DR (2000) Neuronal correlates of fear in the lateral amygdala: multiple extracellular recordings in conscious cats. J Neurosci 20:2701–2710PubMed
Penttonen M, Buzsáki G (2003) Natural logarithmic relationship between brain oscillators. Thalamus Relat Syst 2:145–152CrossRef
Perrin F, Schnakers C, Schabus M, Degueldre C, Goldman S, Bredart S et al (2006) Brain response to one’s own name in vegetative state, minimally conscious state, and locked-in syndrome. Arch Neurol 63:562–569PubMedCrossRef
Pfurtscheller G, Neuper C, Schlogl A, Lugger K (1998) Separability of EEG signals recorded during right and left motor imagery using adaptive autoregressive parameters. IEEE Trans Rehabil Eng 6:316–325PubMedCrossRef
Plum F, Schiff N, Ribary U, Llinás R (1998) Coordinated expression in chronically unconscious persons. Philos Trans R Soc Lond B Biol Sci 353:1929–1933PubMedCrossRef
Pockett S, Holmes MD (2009) Intracranial EEG power spectra and phase synchrony during consciousness and unconsciousness. Conscious Cogn 18(4):1049–1055PubMedCrossRef
Pulvermüller F, Preissl H, Lutzenberger W, Birbaumer N (1995) Spectral responses in the gamma-band: physiological signs of higher cognitive processes? NeuroReport 6:2057–2064CrossRef
Ray WJ, Cole HW (1985) EEG alpha activity reflects attentional demands, and beta activity reflects emotional and cognitive processes. Science 228:750–752PubMedCrossRef
Reijneveld JC, Ponten SC, Berendse HW, Stam CJ (2007) The application of graph theoretical analysis to complex networks in the brain. Clin Neurophysiol 118:2317–2331PubMedCrossRef
Revonsuo A (2006) Inner presence: consciousness as a biological phenomenon. MIT Press, Cambridge
Robinson PA, Rennie CJ, Wright JJ, Bahramali H, Gordon E, Rowe DL (2001) Prediction of electroencephalographic spectra from neurophysiology. Phys Rev E 63:021903-1–021903-18
Royal College of Physicians (UK) (2003) The vegetative state: guidance on diagnosis and management. A report of a working party of the Royal College of Physicians. Clin Med 2:249–254
Rusalova MN (2006) Frequency-amplitude characteristics of the EEG at different levels of consciousness. Neurosci Behav Physiol 36(4):351–358PubMedCrossRef
Ryali S, Glover GH, Chang C, Menon V (2009) Development, validation, and comparison of ICA-based gradient artifact reduction algorithms for simultaneous EEG-spiral in/out and echo-planar fMRI recordings. NeuroImage 48(2):348–361PubMedCrossRef
Sachs G, Anderer P, Dantendorfer K, Saletu B (2004) EEG mapping in patients with social phobia. Psychiatry Res Neuroimaging 131:237–247CrossRef
Sakatani K, Murata Y, Fukaya C, Yamamoto T, Katayama Y (2003) BOLD functional MRI may overlook activation areas in the damaged brain. Acta Neurochir Suppl 87:59–62PubMed
Salek-Haddadi A, Lemieux L, Merschhemke M, Friston KJ, Duncan JS, Fish DR (2003) Functional magnetic resonance imaging of human absence seizures. Ann Neurol 53:663–667PubMedCrossRef
Schack B, Klimesch W, Sauseng P (2005) Phase synchronization between theta and upper alpha oscillations in a working memory task. Int J Psychophysiol 57:105–114PubMedCrossRef
Schiff ND, Plum F (1999) Cortical function in the persistent vegetative state. Trends Cogn Sci 3:43–44PubMedCrossRef
Schiff ND, Ribary U, Moreno DR, Beattie B, Kronberg E, Blasberg R et al (2002) Residual cerebral activity and behavioural segments can remain in the persistently vegetative brain. Brain 125:1210–1234PubMedCrossRef
Schiff ND, Rodriguez-Moreno D, Kamal A, Kim KH, Giacino JT, Plum F, Hirsch J (2005) fMRI reveals large-scale network activation in minimally conscious patients. Neurology 64:514–523PubMedCrossRef
Schnakers C, Giacino J, Kalmar K, Piret S, Lopez E, Boly M et al (2006) Does the FOUR correctly diagnose the vegetative and minimally conscious states? Ann Neurol 60:744–745PubMedCrossRef
Schnakers C, Vanhaudenhuyse A, Giacino J, Ventura M, Boly M, Majerus S et al (2009) Diagnostic accuracy of the vegetative and minimally conscious state: clinical consensus versus standardized neurobehavioral assessment. BMC Neurol 9:35PubMedCrossRef
Schoenle PW, Witzke W (2004) How vegetative is the vegetative state? Preserved semantic processing in vegetative state patients: evidence from N 400 eventrelated potentials. Neuro Rehabil 19:329–334
Schölvinck ML, Howarth C, Attwell D (2008) The cortical energy needed for conscious perception. NeuroImage 40:1460–1468PubMedCrossRef
Schönle PW, Schwall D (1993) Habituation des blinkreflexes als zeichen früher lernvorgänge bei apallischen patienten. In: von Wild K (ed) Spektrum der neurorehabilitation. Zuckschwerdt, München, pp 158–163
Shaw JC (2003) The brain’s alpha rhythms and the mind. Elsevier Science BV, Amsterdam
Singer W (1999) Neuronal synchrony: a versatile code for the definition of relations? Neuron 24:49–65PubMedCrossRef
Singer W (2001) Consciousness and the binding problem. Annals NY Acad Sci 929:123–146CrossRef
Singer W, Engel AK, Kreiter AK, Munk MHJ, Neuenschwander S, Roelfsema PR (1997) Neural assemblies: necessity, signature and detectability. Trends Cogn Sci 1:252–261PubMedCrossRef
Sleigh J, Steyn-Ross M, Steyn-Ross A, Voss L, Wilson M (2010) Anesthesia-induced state transitions in neuronal populations. In: Hudetz A, Pearce R (eds) Suppressing the mind: contemporary clinical neuroscience. Humana Press, New York, pp 139–160
Sokolov EN (1963) Higher nervous functions: the orienting reflex. Annu Rev Physiol 25:545–580PubMedCrossRef
Stam CJ (2005) Nonlinear dynamical analysis of EEG and MEG: review of an emerging field. Clin Neurophysiol 116:2266–2301PubMedCrossRef
Stam CJ (2006) Nonlinear brain dynamics. Nova Science Publishers Inc, Hauppauge
Steriade M (2000) Corticothalamic resonance, states of vigilance and mentation. Neuroscience 101:243–276PubMedCrossRef
Tallroth G, Lindgren M, Stenberg G, Rosen I, Agardh CD (1990) Neurophysiological changes during insulin-induced hypoglycaemia and in the recovery period following glucose infusion in Type I (insulin-dependent) diabetes mellitus and in normal man. Diabetologia 33:319–323PubMedCrossRef
Thatcher RW, Krause PJ, Hrybyk M (1986) Cortico-cortical associations and EEG coherence: a two-compartmental model. Electroencephalogr Clin Neurophysiol 64:123–143PubMedCrossRef
Thatcher RW, Walker RA, Giudice S (1987) Human cerebral hemispheres develop at different rates and ages. Science 236:1110–1113PubMedCrossRef
The Multi-Society Task Force on PVS (1994) Medical aspects of the persistent vegetative state (1). New England J Med 330:1499–1508CrossRef
Toates F (1998) The interaction of cognitive and stimulus–response processes in the control of behaviour. Neurosci Biobehav Rev 22:59–83PubMedCrossRef
Tononi G (2008) Consciousness as integrated information: a provisional manifesto. Biol Bull 215:216–242PubMedCrossRef
Tononi G, Laureys S (2008) The neurology of consciousness: an overview. In: Laureys S, Tononi G (eds) The neurology of consciousness. Elsevier, Oxford, pp 375–412
Treisman AM, Kanwisher NG (1998) Perceiving visually presented objects: recognition awareness and modularity. Curr Opin Neurobiol 8:218–226PubMedCrossRef
Truccolo WA, Ding M, Knuth KH, Nakamura R, Bressler S (2002) Trial-to-trial variability of cortical evoked responses: implications for analysis of functional connectivity. Clin Neurophysiol 113:206–226PubMedCrossRef
van Elk M, van Schie HT, van den Heuvel R, Bekkering H (2010) Semantics in the motor system: motorcortical beta oscillations reflect semantic knowledge of end-postures for object use. Front Hum Neurosci 4:8PubMed
van Leeuwen C (2007) What needs to emerge to make you conscious? J Conscious Stud 14:115–136
Vanhaudenhuyse A, Noirhomme Q, Tshibanda LJ-F, Bruno M-A, Boveroux P, Schnakers C et al (2010) Default network connectivity reflects the level of consciousness in non-communicative brain-damaged patients. Brain 133:161–171PubMedCrossRef
Varela F (1995) Resonant cell assemblies: a new approach to cognitive functions and neuronal synchrony. Biol Res 28:81–95PubMed
Varela F, Lachaux JP, Rodriguez E, Martinerie J (2001) The brain web: phase synchronization and large-scale integration. Nat Rev Neurosci 2:229–239PubMedCrossRef
Velmans M (1991) Is human information processing conscious? Behav Brain Sci 14:651–726CrossRef
von der Malsburg C (1999) The what and why of binding: the modeler’s perspective. Neuron 24:95–104CrossRef
von Stein A, Chiang C, König P (2000) Top-down processing mediated by interareal synchronization. Proc Natl Acad Sci USA 97:14748–14753CrossRef
Wackermann J, Allefeld C (2007) On the meaning and interpretation of global descriptors of brain electrical activity. Including a reply to X. Pei et al. Int J Psychophysiol 64:199–210PubMedCrossRef
Weiss S, Rappelsberger P (2000) Long-range EEG synchronization during word encoding correlates with successful memory performance. Brain Res Cogn Brain Res 9:299–312PubMedCrossRef
Whitham EM, Pope KJ, Fitzgibbon SP, Lewis T, Clark CR, Loveless S et al (2007) Scalp electrical recording during paralysis: quantitative evidence that EEG frequencies above 20 Hz are contaminated by EMG. Clin Neurophysiol 118:1877–1888PubMedCrossRef
Williamson PC, Csima A, Galin H, Mamelak M (1986) Spectral EEG correlates of dream recall. Biol Psychiatry 21:717–723PubMedCrossRef
Yingling CD (2001) Neural mechanisms of unconscious cognitive processing. Clin Neurophysiol 112:157–158PubMedCrossRef
Yuval-Greenberg S, Tomer O, Keren AS, Nelken I, Deouell LY (2008) Transient induced gamma-band response in EEG as a manifestation of miniature saccades. Neuron 58:429–441PubMedCrossRef
Metadaten
Titel
Toward operational architectonics of consciousness: basic evidence from patients with severe cerebral injuries
verfasst von
Andrew A. Fingelkurts
Alexander A. Fingelkurts
Sergio Bagnato
Cristina Boccagni
Giuseppe Galardi
Publikationsdatum
01.05.2012
Verlag
Springer-Verlag
Erschienen in
Cognitive Processing / Ausgabe 2/2012
Print ISSN: 1612-4782
Elektronische ISSN: 1612-4790
DOI
https://doi.org/10.1007/s10339-011-0416-x

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