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Polymer Bulletin
Erschienen in: Polymer Bulletin 5/2017

19.09.2016 | Original Paper

Antibacterial and antitumor activities of 3-amino-phenyl-4(3H)-quinazolinone/polypyrrole chitosan core shell nanoparticles

verfasst von: Nehal Salahuddin, Ahmed A. Elbarbary, Hend A. Alkabes

Erschienen in: Polymer Bulletin | Ausgabe 5/2017

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Abstract

3-Amino-2-phenyl-4(3H)-quinazolinone (I) was prepared and loaded on polypyrrole chitosan (PPC) core shell nanoparticles (PPCI). The formation of core shell PPC nanoparticles were observed by transmission electron microscopy (TEM). The interaction between I and the synthesized PPC core shell nanoparticle was studied by Fourier transform infrared (FT-IR) spectroscopy. The average particle size of the PPC was 13 and 33 nm after loading I as determined by Scherer equation from X-ray diffraction (XRD) analysis. The synthesized PPCI exhibited antibacterial activity against gram negative as well as gram positive bacteria. In addition, the amount of loaded quinazolinone was calculated by thermal gravimetric analysis (TGA). The released amount of quinazolinone in different pH (2, 7.4) media and the mechanism of release by applying different model equations were studied. Moreover, the in vitro effect of the nanoparticles on Erlich ascites carcinoma (EAC) cells was enhanced after loading I.
Vorheriger Artikel Dapsone uptake and release from plasma polypyrrole for drug administration
Nächster Artikel Development of cyclophosphazene and rice husk ash incorporated epoxy composites for high performance applications

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Metadaten
Titel
Antibacterial and antitumor activities of 3-amino-phenyl-4(3H)-quinazolinone/polypyrrole chitosan core shell nanoparticles
verfasst von
Nehal Salahuddin
Ahmed A. Elbarbary
Hend A. Alkabes
Publikationsdatum
19.09.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
Polymer Bulletin / Ausgabe 5/2017
Print ISSN: 0170-0839
Elektronische ISSN: 1436-2449
DOI
https://doi.org/10.1007/s00289-016-1804-2

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