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2013 | OriginalPaper | Buchkapitel

Automated Measurement and Monitoring of Bioprocesses: Key Elements of the M³C Strategy

verfasst von : Bernhard Sonnleitner

Erschienen in: Measurement, Monitoring, Modelling and Control of Bioprocesses

Verlag: Springer Berlin Heidelberg

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Abstract

The state-of-routine monitoring items established in the bioprocess industry as well as some important state-of-the-art methods are briefly described and the potential pitfalls discussed. Among those are physical and chemical variables such as temperature, pressure, weight, volume, mass and volumetric flow rates, pH, redox potential, gas partial pressures in the liquid and molar fractions in the gas phase, infrared spectral analysis of the liquid phase, and calorimetry over an entire reactor. Classical as well as new optical versions are addressed. Biomass and bio-activity monitoring (as opposed to “measurement”) via turbidity, permittivity, in situ microscopy, and fluorescence are critically analyzed. Some new(er) instrumental analytical tools, interfaced to bioprocesses, are explained. Among those are chromatographic methods, mass spectrometry, flow and sequential injection analyses, field flow fractionation, capillary electrophoresis, and flow cytometry. This chapter surveys the principles of monitoring rather than compiling instruments.

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Titel: Automated Measurement and Monitoring of Bioprocesses: Key Elements of the M3C Strategy
verfasst von: Bernhard Sonnleitner
Verlag: Springer Berlin Heidelberg
Buch: Measurement, Monitoring, Modelling and Control of Bioprocesses
Print ISBN: 978-3-642-36837-0

Electronic ISBN: 978-3-642-36838-7

Copyright-Jahr: 2013
DOI: https://doi.org/10.1007/10_2012_173

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