nach oben

Erschienen in:

2019 | OriginalPaper | Buchkapitel

5. Bioanalytical Advancements in the Reliable Visualization and Discrimination of Bodily Fluids

verfasst von : James Gooch, Alvaro Varela Morillas, Nunzianda Frascione

Erschienen in: Emerging Technologies for the Analysis of Forensic Traces

Verlag: Springer International Publishing

Einloggen

Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.

search-config

KI-gestützte Suche

Aus

Abstract

Body fluids are an important form of biological trace evidence that can be used to substantially inform many aspects of criminal investigations; fluids such as blood, semen, and saliva can provide investigators with more information about the specific nature of an offence and associate individuals with a crime via DNA profiling. However, many of the techniques currently used to locate and identify body fluids left at crime scenes suffer from low specificity, sample destruction and lengthy operation times. As a result, many members of the forensic and academic communities are working together towards the development of new rapid, sensitive and specific body fluid analysis methods. This chapter initially provides an overview of the fluid detection and attribution strategies currently employed within routine forensic casework and their associated weaknesses. Next, a selection of spectroscopic and molecular techniques that show the most promise as replacements for traditional fluid testing strategies, along with the merits and limitations of each method, are described.

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

über 102.000 Bücher
über 537 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Finance + Banking
Management + Führung
Marketing + Vertrieb
Maschinenbau + Werkstoffe
Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Jetzt informieren

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

über 67.000 Bücher
über 390 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Maschinenbau + Werkstoffe

Jetzt Wissensvorsprung sichern!

Jetzt informieren

Vorheriges Kapitel End User Commentary on Novel Technological Applications for Latent and Blood-Stained Fingermark Aging Studies

Nächstes Kapitel End User Commentary on Bioanalytical Advancements in the Reliable Visualization and Discrimination of Bodily Fluids

Cleland JD, Johnson E, Morel PCH, Kenyon PR, Waterland MR (2018) Mid-infrared reflectance spectroscopy as a tool for forage feed composition prediction. Anim Feed Sci Tech 241:102–111CrossRef

Kayser M (2015) Forensic DNA phenotyping: predicting human appearance from crime scene material for investigative purposes. Forensic Sci Int Genet 18:33–48CrossRefPubMed

Virkler K, Lednev IK (2009) Analysis of body fluids for forensic purposes: from laboratory testing to non-destructive rapid confirmatory identification at a crime scene. Forensic Sci Int 188(1–3):1–17CrossRefPubMed

Lee W, Khoo B (2010) Forensic light sources for detection of biological evidences in crime scene investigation: a review. Malaysian J Forensic Sci 1:17–28

Specht W (1937) Die Chemiluminescenz des Hämins, ein Hilfsmittel zur Auffindung und Erkennung forensisch wichtiger Blutspuren. Dtsch Z Gesamte Gerichtl Med 28(1):225–234

Dilbeck L (2006) Use of Bluestar Forensic in lieu of luminol at crime scenes. J Forensic Identif 56(5):706

Monk JW (1991) Fluorescent bloodstain detection: a replacement for luminol. California Criminalistics Institute, California, USA

Lowis T, Leslie K, Barksdale LE, Carter DO (2012) Determining the sensitivity and reliability of hemascein. J Forensic Identif 62(3):204–214

Radacher M, Dunkelmann B, Höckner G, Neuhuber F, Pölzgutter E, Breksler E, Baderer D, Steinletzberger N (2011) Luminol im Vergleich mit Fluorescein und Blue Star, Blue Star Forensic Magnum im Vergleich mit Lumiscene. Kriminalistik 3:180–184

10.

Kind SS (1956) The use of the acid phosphatase test in searching for seminal stains. J Crim Law Criminol 47:597CrossRef

11.

Hedman J, Gustavsson K, Ansell R (2008) Using the new Phadebas^® Forensic Press test to find crime scene saliva stains suitable for DNA analysis. Forensic Sci Int Genet 1(1):430–432CrossRef

12.

Gill P (2016) Analysis and implications of the miscarriages of justice of Amanda Knox and Raffaele Sollecito. Forensic Sci Int Genet 23:9–18CrossRefPubMed

13.

Leonards JR (1962) Simple test for hematuria compared with established tests. JAMA 179(10):807–808CrossRefPubMed

14.

Glaister J (1926) The Kastle-Meyer test for the detection of blood—considered from the medico-legal aspect. Brit Med J 1926(3406):650–652CrossRef

15.

Adler O, Adler R (1904) Über das Verhalten gewisser organischer Verbindungen gegenüber Blut mit besonderer Berücksichtigung des Nachweises von Blut. Hoppe-Seyler’s Z Physiol Chem 41

16.

Johnston S, Newman J, Frappier R (2003) Validation study of the Abacus Diagnostics ABAcard^® HemaTrace^® membrane test for the forensic identification of human blood. Can Soc Forensic Sci J 36(3):173–183CrossRef

17.

Hochmeister MN, Budowle B, Sparkes R, Rudin O, Gehrig C, Thali M, Schmidt L, Cordier A, Dirnhofer R (1999) Validation studies of an immunochromatographic 1-step test for the forensic identification of human blood. J Forensic Sci 44(3):597–602CrossRefPubMed

18.

Misencik A, Laux DL (2007) Validation study of the seratec hemdirect hemoglobin assay for the forensic identification of human blood. MAFS Newslett 36(2):18–26

19.

Schweers BA, Old J, Boonlayangoor PW, Reich KA (2008) Developmental validation of a novel lateral flow strip test for rapid identification of human blood (rapid stain identification–blood). Forensic Sci Int Genet 2(3):243–247CrossRefPubMed

20.

Takayama M (1912) A method for identifying blood by hemochromogen crystallization. J Kokka Igakkai Zasshi 306:15–33

21.

Teichmann L (1853) Ueber die Krystallisation des orpnischen Be-standtheile des Blutes. Ration Med 3:375–388

22.

Walker JT (1950) A new test for seminal stains. N Engl J Med 242(3):110CrossRefPubMed

23.

Kearsey J, Louie H, Poon H (2001) Validation study of the “Onestep Abacard^® PSA Test” kit for RCMP Casework. Can Soc Forensic Sci J 34(2):63–72CrossRef

24.

Maher J, Vintiner S, Elliot D, Melia L (2002) Evaluation of the BioSign (TM) PSA membrane test for the identification of semen stains in forensic casework. New Zeal Med J 115(1147):48–49PubMed

25.

Gartside BO, Brewer KJ, Strong CL (2003) Estimation of Prostate-Specific Antigen (PSA) extraction efficiency from forensic samples using the seratec PSA Semiquant Semiquantitative Membrane test. FSC 5(2):1–4

26.

Old J, Schweers BA, Boonlayangoor PW, Fischer B, Miller KW, Reich K (2012) Developmental validation of RSID™-semen: a lateral flow immunochromatographic strip test for the forensic detection of human semen. J Forensic Sci 57(2):489–499CrossRefPubMed

27.

Willott GM (1974) An improved test for the detection of salivary amylase in stains. J Forensic Sci Soc 14(4):341–344CrossRefPubMed

28.

Old JB, Schweers BA, Boonlayangoor PW, Reich KA (2009) Developmental validation of RSID™-saliva: a lateral flow immunochromatographic strip test for the forensic detection of saliva. J Forensic Sci 54(4):866–873CrossRefPubMed

29.

Barbaro A, Cormaci P, Votano S, La Marca A (2015) Evaluation study about the SERATEC (R) rapid tests. Forensic Sci Int Genet 5:E63–E64CrossRef

30.

Pang BC, Cheung BK (2008) Applicability of two commercially available kits for forensic identification of saliva stains. J Forensic Sci 53(5):1117–1122CrossRefPubMed

31.

Ong SY, Wain A, Groombridge L, Grimes E (2012) Forensic identification of urine using the DMAC test: a method validation study. Sci Justice 52(2):90–95CrossRefPubMed

32.

Akutsu T, Watanabe K, Sakurada K (2012) Specificity, sensitivity, and operability of RSID™-urine for forensic identification of urine: comparison with Elisa for Tamm-Horsfall protein. J Forensic Sci 57(6):1570–1573CrossRefPubMed

33.

Romsos EL, Vallone PM (2015) Rapid PCR of STR markers: applications to human identification. Forensic Sci Int Genet 18:90–99CrossRefPubMed

34.

Zapata F, de la Ossa MAF, Garcia-Ruiz C (2015) Emerging spectrometric techniques for the forensic analysis of body fluids. Trends Analyt Chem 64:53–63CrossRef

35.

Tobe SS, Watson N, Daeid NN (2007) Evaluation of six presumptive tests for blood, their specificity, sensitivity, and effect on high molecular-weight DNA. J Forensic Sci 52(1):102–109CrossRefPubMed

36.

Chalmers JM, Edwards HG, Hargreaves MD (2012) Infrared and Raman spectroscopy in forensic science, 1st edn. Wiley

37.

Reich G (2005) Near-infrared spectroscopy and imaging: basic principles and pharmaceutical applications. Adv Drug Deliv Rev 57(8):1109–1143CrossRefPubMed

38.

Ozaki Y (2012) Near-infrared spectroscopy—its versatility in analytical chemistry. Anal Sci 28(6):545–563CrossRefPubMed

39.

Morillas AV, Gooch J, Frascione N (2018) Feasibility of a handheld near infrared device for the qualitative analysis of bloodstains. Talanta 184:1–6CrossRefPubMed

40.

Pereira JFQ, Silva CS, Vieira MJL, Pimentel MF, Braz A, Honorato RS (2017) Evaluation and identification of blood stains with handheld NIR spectrometer. Microchem J 133:561–566CrossRef

41.

Orphanou CM, Walton-Williams L, Mountain H, Cassella J (2015) The detection and discrimination of human body fluids using ATR FT-IR spectroscopy. Forensic Sci Int 252:e10–e16CrossRefPubMed

42.

Elkins KM (2011) Rapid presumptive “fingerprinting” of body fluids and materials by ATR FT-IR spectroscopy. J Forensic Sci 56(6):1580–1587CrossRefPubMed

43.

Sikirzhytski V, Sikirzhytskaya A, Lednev IK (2011) Multidimensional Raman spectroscopic signatures as a tool for forensic identification of body fluid traces: a review. Appl Spectrosc 65(11):1223–1232CrossRefPubMed

44.

De Wael K, Lepot L, Gason F, Gilbert B (2008) In search of blood–detection of minute particles using spectroscopic methods. Forensic Sci Int 180(1):37–42CrossRefPubMed

45.

Muro CK, Doty KC, Fernandes LD, Lednev IK (2016) Forensic body fluid identification and differentiation by Raman spectroscopy. Forensic Chem 1:31–38CrossRef

46.

Doty KC, Lednev IK (2018) Differentiating donor age groups based on Raman spectroscopy of bloodstains for forensic purposes. ACS Cent Sci 4(7):862–867CrossRefPubMedPubMedCentral

47.

Muro CK, de Souza Fernandes L, Lednev IK (2016) Sex determination based on Raman spectroscopy of saliva traces for forensic purposes. Anal Chem 88(24):12489–12493CrossRefPubMed

48.

Mistek E, Halamkova L, Doty KC, Muro CK, Lednev IK (2016) Race differentiation by Raman spectroscopy of a bloodstain for forensic purposes. Anal Chem 88(15):7453–7456CrossRefPubMed

49.

Boyd S, Bertino MF, Ye D, White LS, Seashols SJ (2013) Highly sensitive detection of blood by surface enhanced Raman scattering. J Forensic Sci 58(3):753–756CrossRefPubMed

50.

Sikirzhytski V, Virkler K, Lednev IK (2010) Discriminant analysis of Raman spectra for body fluid identification for forensic purposes. Sensors (Basel) 10(4):2869–2884CrossRef

51.

Edelman GJ, Gaston E, van Leeuwen TG, Cullen PJ, Aalders MC (2012) Hyperspectral imaging for non-contact analysis of forensic traces. Forensic Sci Int 223(1–3):28–39CrossRefPubMed

52.

Edelman G, van Leeuwen TG, Aalders MC (2012) Hyperspectral imaging for the age estimation of blood stains at the crime scene. Forensic Sci Int 223(1–3):72–77CrossRefPubMed

53.

Li B, Beveridge P, O’Hare WT, Islam M (2013) The age estimation of blood stains up to 30 days old using visible wavelength hyperspectral image analysis and linear discriminant analysis. Sci Justice 53(3):270–277CrossRefPubMed

54.

Li B, Beveridge P, O’Hare WT, Islam M (2014) The application of visible wavelength reflectance hyperspectral imaging for the detection and identification of blood stains. Sci Justice 54(6):432–438CrossRefPubMed

55.

Edelman GJ, van Leeuwen TG, Aalders MC (2015) Visualization of latent blood stains using visible reflectance hyperspectral imaging and chemometrics. J Forensic Sci 60 Suppl 1(s1):S188–S192

56.

Edelman G, Manti V, van Ruth SM, van Leeuwen T, Aalders M (2012) Identification and age estimation of blood stains on colored backgrounds by near infrared spectroscopy. Forensic Sci Int 220(1–3):239–244CrossRefPubMed

57.

Zapata F, Ortega-Ojeda FE, Garcia-Ruiz C (2017) Revealing the location of semen, vaginal fluid and urine in stained evidence through near infrared chemical imaging. Talanta 166:292–299CrossRefPubMed

58.

Silva CS, Pimentel MF, Amigo JM, Honorato RS, Pasquini C (2017) Detecting semen stains on fabrics using near infrared hyperspectral images and multivariate models. Trends Analyt Chem 95:23–35CrossRef

59.

Sijen T (2015) Molecular approaches for forensic cell type identification: on mRNA, miRNA, DNA methylation and microbial markers. Forensic Sci Int Genet 18:21–32CrossRefPubMed

60.

Park JL, Park SM, Kim JH, Lee HC, Lee SH, Woo KM, Kim SY (2013) Forensic body fluid identification by analysis of multiple RNA markers using nanostring technology. Genomics Inform 11(4):277–281CrossRefPubMedPubMedCentral

61.

Juusola J, Ballantyne J (2007) mRNA profiling for body fluid identification by multiplex quantitative RT-PCR. J Forensic Sci 52(6):1252–1262PubMed

62.

Fang R, Manohar CF, Shulse C, Brevnov M, Wong A, Petrauskene OV, Brzoska P, Furtado MR (2006) Real-time PCR assays for the detection of tissue and body fluid specific mRNAs. Int Congr Ser 1288:685–687CrossRef

63.

Juusola J, Ballantyne J (2005) Multiplex mRNA profiling for the identification of body fluids. Forensic Sci Int 152(1):1–12CrossRefPubMed

64.

Noreault-Conti TL, Buel E (2007) The use of real-time PCR for forensic stain identification. Promega Profiles DNA 10(1):3–5

65.

Lindenbergh A, de Pagter M, Ramdayal G, Visser M, Zubakov D, Kayser M, Sijen T (2012) A multiplex (m)RNA-profiling system for the forensic identification of body fluids and contact traces. Forensic Sci Int Genet 6(5):565–577CrossRefPubMed

66.

Zubakov D, Hanekamp E, Kokshoorn M, van Ijcken W, Kayser M (2008) Stable RNA markers for identification of blood and saliva stains revealed from whole genome expression analysis of time-wise degraded samples. Int J Legal Med 122(2):135–142CrossRefPubMed

67.

Bauer M, Patzelt D (2003) Protamine mRNA as molecular marker for spermatozoa in semen stains. Int J Legal Med 117(3):175–179PubMed

68.

Juusola J, Ballantyne J (2003) Messenger RNA profiling: a prototype method to supplant conventional methods for body fluid identification. Forensic Sci Int 135(2):85–96CrossRefPubMed

69.

Ingold S, Dørum G, Hanson E, Berti A, Branicki W, Brito P, Elsmore P, Gettings K, Giangasparo F, Gross T (2018) Body fluid identification using a targeted mRNA massively parallel sequencing approach–results of a EUROFORGEN/EDNAP collaborative exercise. Forensic Sci Int Genet 34:105–115CrossRefPubMed

70.

Haas C, Hanson E, Anjos MJ, Banemann R, Berti A, Borges E, Carracedo A, Carvalho M, Courts C, De Cock G, Dotsch M, Flynn S, Gomes I, Hollard C, Hjort B, Hoff-Olsen P, Hribikova K, Lindenbergh A, Ludes B, Maronas O, McCallum N, Moore D, Morling N, Niederstatter H, Noel F, Parson W, Popielarz C, Rapone C, Roeder AD, Ruiz Y, Sauer E, Schneider PM, Sijen T, Court DS, Sviezena B, Turanska M, Vidaki A, Zatkalikova L, Ballantyne J (2013) RNA/DNA co-analysis from human saliva and semen stains—results of a third collaborative EDNAP exercise. Forensic Sci Int Genet 7(2):230–239CrossRefPubMed

71.

Hanson EK, Ballantyne J (2013) Highly specific mRNA biomarkers for the identification of vaginal secretions in sexual assault investigations. Sci Justice 53(1):14–22CrossRefPubMed

72.

Hanson E, Ingold S, Haas C, Ballantyne J (2018) Messenger RNA biomarker signatures for forensic body fluid identification revealed by targeted RNA sequencing. Forensic Sci Int Genet 34:206–221CrossRefPubMed

73.

Bauer M, Patzelt D (2002) Evaluation of mRNA markers for the identification of menstrual blood. J Forensic Sci 47(6):1278–1282CrossRefPubMed

74.

Roeder AD, Haas C (2013) mRNA profiling using a minimum of five mRNA markers per body fluid and a novel scoring method for body fluid identification. Int J Legal Med 127(4):707–721CrossRefPubMed

75.

Hanson E, Haas C, Jucker R, Ballantyne J (2012) Specific and sensitive mRNA biomarkers for the identification of skin in ‘touch DNA’ evidence. Forensic Sci Int Genet 6(5):548–558CrossRefPubMed

76.

Ingold S, Haas C, Dorum G, Hanson E, Ballantyne J (2017) Association of a body fluid with a DNA profile by targeted RNA/DNA deep sequencing. Forensic Sci Int Genet 6:E112–E113CrossRef

77.

de Zoete J, Curran J, Sjerps M (2016) A probabilistic approach for the interpretation of RNA profiles as cell type evidence. Forensic Sci Int Genet 20:30–44CrossRefPubMed

78.

Dorum G, Ingold S, Hanson E, Ballantyne J, Snipen L, Haas C (2018) Predicting the origin of stains from next generation sequencing mRNA data. Forensic Sci Int Genet 34:37–48CrossRefPubMed

79.

Lindenbergh A, Maaskant P, Sijen T (2013) Implementation of RNA profiling in forensic casework. Forensic Sci Int Genet 7(1):159–166CrossRefPubMed

80.

Harbison S, Fleming R (2016) Forensic body fluid identification: state of the art. RRFMS 6:11–23CrossRef

81.

Zapata F, Gregorio I (2016) Body fluids and spectroscopic techniques in forensics: a perfect match? J Forensic Med 1(1):1–7CrossRef

82.

Alvarez M, Juusola J, Ballantyne J (2004) An mRNA and DNA co-isolation method for forensic casework samples. Anal Biochem 335(2):289–298CrossRefPubMed

83.

Vennemann M, Koppelkamm A (2010) mRNA profiling in forensic genetics I: possibilities and limitations. Forensic Sci Int 203(1–3):71–75CrossRefPubMed

84.

Kohlmeier F, Schneider PM (2012) Successful mRNA profiling of 23 years old blood stains. Forensic Sci Int Genet 6(2):274–276CrossRefPubMed

85.

Zubakov D, Kokshoorn M, Kloosterman A, Kayser M (2009) New markers for old stains: stable mRNA markers for blood and saliva identification from up to 16-year-old stains. Int J Legal Med 123(1):71–74CrossRefPubMed

86.

Goldberg AD, Allis CD, Bernstein E (2007) Epigenetics: a landscape takes shape. Cell 128(4):635–638CrossRefPubMed

87.

Alegría-Torres JA, Baccarelli A, Bollati V (2011) Epigenetics and lifestyle. Epigenomics 3(3):267–277CrossRefPubMed

88.

Li C, Zhang S, Que T, Li L, Zhao S (2011) Identical but not the same: the value of DNA methylation profiling in forensic discrimination within monozygotic twins. Forensic Sci Int Genet 3(1):e337–e338CrossRef

89.

Vidaki A, Ballard D, Aliferi A, Miller TH, Barron LP, Court DS (2017) DNA methylation-based forensic age prediction using artificial neural networks and next generation sequencing. Forensic Sci Int Genet 28:225–236CrossRefPubMedPubMedCentral

90.

Ehrlich M, Gama-Sosa MA, Huang LH, Midgett RM, Kuo KC, McCune RA, Gehrke C (1982) Amount and distribution of 5-methylcytosine in human DNA from different types of tissues of cells. Nucleic Acids Res 10(8):2709–2721CrossRefPubMedPubMedCentral

91.

Frumkin D, Wasserstrom A, Budowle B, Davidson A (2011) DNA methylation-based forensic tissue identification. Forensic Sci Int Genet 5(5):517–524CrossRefPubMed

92.

Vidaki A, Daniel B (2013) Forensic DNA methylation profiling—potential opportunities and challenges. Forensic Sci Int Genet 7(5):499–507CrossRefPubMed

93.

Vidaki A, Kayser M (2017) From forensic epigenetics to forensic epigenomics: broadening DNA investigative intelligence. Genome Biol 18(1):238CrossRefPubMedPubMedCentral

94.

Naue J, Sanger T, Hoefsloot HCJ, Lutz-Bonengel S, Kloosterman AD, Verschure PJ (2018) Proof of concept study of age-dependent DNA methylation markers across different tissues by massive parallel sequencing. Forensic Sci Int Genet 36:152–159CrossRefPubMed

95.

Christensen BC, Houseman EA, Marsit CJ, Zheng S, Wrensch MR, Wiemels JL, Nelson HH, Karagas MR, Padbury JF, Bueno R, Sugarbaker DJ, Yeh RF, Wiencke JK, Kelsey KT (2009) Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context. Forensic Sci Int Genet 5(8):e1000602

96.

Wasserstrom A, Frumkin D, Davidson A, Shpitzen M, Herman Y, Gafny R (2013) Demonstration of DSI-semen—a novel DNA methylation-based forensic semen identification assay. Forensic Sci Int Genet 7(1):136–142CrossRefPubMed

97.

Sender R, Fuchs S, Milo R (2016) Are we really vastly outnumbered? Revisiting the ratio of bacterial to host cells in humans. Cell 164(3):337–340CrossRefPubMed

98.

Turnbaugh PJ, Ley RE, Hamady M, Fraser-Liggett CM, Knight R, Gordon JI (2007) The human microbiome project. Nature 449(7164):804–810CrossRefPubMedPubMedCentral

99.

Lane DJ, Pace B, Olsen GJ, Stahl DA, Sogin ML, Pace NR (1985) Rapid determination of 16S ribosomal RNA sequences for phylogenetic analyses. Proc Natl Acad Sci U S A 82(20):6955–6959CrossRefPubMedPubMedCentral

100.

Khodakova AS, Smith RJ, Burgoyne L, Abarno D, Linacre A (2014) Random whole metagenomic sequencing for forensic discrimination of soils. PLoS ONE 9(8):e104996CrossRefPubMedPubMedCentral

101.

Choi A, Shin KJ, Yang WI, Lee HY (2014) Body fluid identification by integrated analysis of DNA methylation and body fluid-specific microbial DNA. Int J Legal Med 128(1):33–41CrossRefPubMed

102.

Hanssen EN, Avershina E, Rudi K, Gill P, Snipen L (2017) Body fluid prediction from microbial patterns for forensic application. Forensic Sci Int Genet 30:10–17CrossRefPubMed

103.

Benschop CC, Quaak FC, Boon ME, Sijen T, Kuiper I (2012) Vaginal microbial flora analysis by next generation sequencing and microarrays; can microbes indicate vaginal origin in a forensic context? Int J Legal Med 126(2):303–310CrossRefPubMed

104.

Dewhirst FE, Klein EA, Thompson EC, Blanton JM, Chen T, Milella L, Buckley CM, Davis IJ, Bennett ML, Marshall-Jones ZV (2012) The canine oral microbiome. PLoS ONE 7(4):e36067CrossRefPubMedPubMedCentral

105.

Banica F-G (2012) Chemical sensors and biosensors: fundamentals and applications, 1st edn. Wiley

106.

Gooch J, Daniel B, Frascione N (2014) Application of fluorescent substrates to the in situ detection of prostate specific antigen. Talanta 125:210–214CrossRefPubMed

107.

Gooch J, Abbate V, Daniel B, Frascione N (2016) Solid-phase synthesis of Rhodamine-110 fluorogenic substrates and their application in forensic analysis. Analyst 141(8):2392–2395CrossRefPubMed

108.

Gooch J, Chua CR, Abbate V, Frascione N (2017) Fluorogenic substrates for the detection of saliva. Forensic Sci Int Genet 6:E565–E567CrossRef

109.

Frascione N, Gooch J, Abbate V, Daniel B (2015) Fluorogenic displacement biosensors for PSA detection using antibody-functionalised quantum dot nanoparticles. Rsc Adv 5(9):6595–6598CrossRef

110.

Frascione N, Pinto V, Daniel B (2012) Development of a biosensor for human blood: new routes to body fluid identification. Anal Bioanal Chem 404(1):23–28CrossRefPubMed

111.

Song KM, Lee S, Ban C (2012) Aptamers and their biological applications. Sensors 12(1):612–631CrossRefPubMedPubMedCentral

112.

Gooch J, Daniel B, Parkin M, Frascione N (2017) Developing aptasensors for forensic analysis. Trends Analyt Chem 94:150–160CrossRef

113.

Song F, Luo H, Hou Y (2015) Developed and evaluated a multiplex mRNA profiling system for body fluid identification in Chinese Han population. J Forensic Leg Med 35:73–80CrossRefPubMed

114.

Lee HY, Jung SE, Lee EH, Yang WI, Shin KJ (2016) DNA methylation profiling for a confirmatory test for blood, saliva, semen, vaginal fluid and menstrual blood. Forensic Sci Int Genet 24:75–82CrossRefPubMed

115.

Frascione N, Gooch J, Daniel B (2013) Enabling fluorescent biosensors for the forensic identification of body fluids. Analyst 138(24):7279–7288CrossRefPubMed

Titel: Bioanalytical Advancements in the Reliable Visualization and Discrimination of Bodily Fluids
verfasst von: James Gooch
Alvaro Varela Morillas
Nunzianda Frascione
Verlag: Springer International Publishing
Buch: Emerging Technologies for the Analysis of Forensic Traces
Print ISBN: 978-3-030-20541-6

Electronic ISBN: 978-3-030-20542-3

Copyright-Jahr: 2019
DOI: https://doi.org/10.1007/978-3-030-20542-3_5

Premium Partner

Marktübersichten

Die im Laufe eines Jahres in der „adhäsion“ veröffentlichten Marktübersichten helfen Anwendern verschiedenster Branchen, sich einen gezielten Überblick über Lieferantenangebote zu verschaffen.

Zur Marktübersicht