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2016 | OriginalPaper | Buchkapitel

2. Contribution to the Recent Advances in Electrochemical Analysis of Pharmaceuticals

verfasst von : Milka L. Avramov Ivić, Slobodan D. Petrović, Dušan Ž. Mijin

Erschienen in: Biomedical and Pharmaceutical Applications of Electrochemistry

Verlag: Springer International Publishing

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Abstract

This review concerns on recent advances in the application of various modern electrochemical techniques to the analysis of pharmaceuticals and biological samples. It is known that different highly sensitive electrochemical techniques are well established in the analysis of selected drugs. The application and choise of the most prefered electrochemical techniques applied to the analysis is closely related on physicochemical properties of the organic functional groups that comprise any given drug structure, especially on redox properties of the pharmaceuticals and biomolecules in real samples.

This chapter describes the application of the most commonly used voltammetric techniques combined with different chromatographic and spectrophotometric as well as spectroscopic techniques in the different aspects of analysis of the pharmaceuticals. Pharmaceutically active compounds under consideration belong to: chemotherapeutic agents (antibiotics), drugs receptor affecting neurotransmission and enzymes as catalytic receptors, drugs affecting the cardiovascular system, drugs affecting the immune systems and some other drugs. The review predominantly discusses over 100 publications from period between 2006–2015, with special emphasis on the solving of large number of different analytical pharmaceutical problems. By using the appropriate electroanalytical techniques, owing to their high sensitivity, selectivity and simplicity, it is possible to overcome some problems in standard pharmaceutical analysis on the best way. The selected our most important papers and observed papers which treat electrochemical analysis of pharmaceuticals are discussed, as much as possible, in the chronological order of their publication. The new electroanalytical methods for qualitative and quantitative determination of standard substancies and as a content of commecial tablets are offered and discussed in analysis of five macrolide antibiotics, amphetamines, carbamazepine, donepezil, amlodipine, nifedipine, clopidogrel, tamiflu, oxaprozin and some other drugs. Some drugs are analized in human biological samples.

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Titel: Contribution to the Recent Advances in Electrochemical Analysis of Pharmaceuticals
verfasst von: Milka L. Avramov Ivić
Slobodan D. Petrović
Dušan Ž. Mijin
Verlag: Springer International Publishing
Buch: Biomedical and Pharmaceutical Applications of Electrochemistry
Print ISBN: 978-3-319-31847-9

Electronic ISBN: 978-3-319-31849-3

Copyright-Jahr: 2016
DOI: https://doi.org/10.1007/978-3-319-31849-3_2

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