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Colloid and Polymer Science
Erschienen in: Colloid and Polymer Science 10/2020

20.08.2020 | Original Contribution

Design and fabrication of novel core-shell nanoparticles for theranostic applications

verfasst von: Seyed Mohammad Reza Dadfar, Saeed Pourmahdian, Mohammad Mehdi Tehranchi, Seyed Mohammadali Dadfar

Erschienen in: Colloid and Polymer Science | Ausgabe 10/2020

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Abstract

Superparamagnetic iron oxide nanoparticles (SPIONs) were prepared by co-precipitation method, functionalized respectively with tetraethyl orthosilicate (TEOS) and 3-(trimethoxysilyl)propyl methacrylate (TMSPM), and monodispersed by filtration and centrifugation. The vinyl-functionalized monodispersed SPIONs were then coated with a shell of the novel dual-responsive hydrogel having semi-interpenetrating polymer network (semi-IPN) structure. The formulation of this hydrogel, which was designed and synthesized in the previous study, was based on sodium alginate (Alg-Na) polymer and temperature-sensitive N-isopropylacrylamide (NIPAA) and pH-sensitive N-ethylmaleamic acid (NEMA) monomers. Sodium alginate acting as a pore-forming agent has a key role in the generation of semi-IPN structure and significantly decreases the time to reach the equilibrium swelling. Totally, two series of core-shell nanoparticles (CSNs) with the same magnetic core and different shell thicknesses were fabricated and exposed to different tests including transmission electron microscopy (TEM), dynamic light scattering (DLS), magnetic property evaluations, and magnetic resonance imaging (MRI) measurements. The obtained results of these tests revealed that these CSNs have the potential to be used as new theranostic platforms for simultaneous cancer diagnosis and therapy.
Vorheriger Artikel Synthesis of polyHIPEs through high internal phase emulsions of β-myrcene
Nächster Artikel Experimental and theoretical studies of benzoquinone modified poly(ortho-phenylenediamine): singlet oxygen generating oligomers

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Metadaten
Titel
Design and fabrication of novel core-shell nanoparticles for theranostic applications
verfasst von
Seyed Mohammad Reza Dadfar
Saeed Pourmahdian
Mohammad Mehdi Tehranchi
Seyed Mohammadali Dadfar
Publikationsdatum
20.08.2020
Verlag
Springer Berlin Heidelberg
Erschienen in
Colloid and Polymer Science / Ausgabe 10/2020
Print ISSN: 0303-402X
Elektronische ISSN: 1435-1536
DOI
https://doi.org/10.1007/s00396-020-04731-3

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