Elaboration of sponge-like particles for textile functionalization and skin penetration

The preparation and characterization of active-loaded microparticles for cosmetic textile applications were studied in this work. The double emulsion diffusion/evaporation technique was served and the Eudragit® RS100 (ethyl acrylate and methyl methacrylate copolymers) was used as biodegradable polymer. Two actives molecules, vitamin E and Lauryl isoquinolinium bromide (LIB) were successfully loaded during the formulation. Obtained particles were spherical in shape with a little variable diameter about 1 μm and zeta potential of 55 mV. The cutaneous penetration of the particles was evaluated by dermal microdialysis, tape stripping, and punch-biopsy techniques from ex vivo human skin. LIB or vitamin E concentrations in the different layers of the skin were analyzed by high-performance liquid chromatography method. Finally, these particles were adsorbed onto a textile in optimized conditions. The scanning electron microscopy is used to confirm the total threads coverage by particles.