Skip to main content
Fachgebiete
Automobil + Motoren Bauwesen + Immobilien Business IT + Informatik Elektrotechnik + Elektronik Energie + Nachhaltigkeit Finance + Banking Management + Führung Marketing + Vertrieb Maschinenbau + Werkstoffe Versicherung + Risiko
DE
EN
Themenseiten
Organisationspsychologie Projektmanagement Marketing Smart Manufacturing
Bücher
Zeitschriften
Weitere Formate
Podcasts Webinare Technik Webinare Wirtschaft Kongresse Veranstaltungskalender Awards
Jetzt Einzelzugang starten
Zugang für Unternehmen
Referenzkunden
MTZ-Fachkongress

Antriebe und Energiesysteme von morgen


Austausch von Automobil- und Energiewirtschaft

Am 14./15. Mai geht es in Chemnitz um die Mobilitätswende durch Elektro- und Wasserstofffahrzeuge.
Erweiterte Suche
Anmelden
nach oben
Polymer Bulletin
Erschienen in: Polymer Bulletin 8/2020

25.09.2019 | Original Paper

Erlotinib–silk fibroin nanoparticles in inhibiting tumor

verfasst von: Hui Li, Hao Qiu, Jiamin Wang, Ziling Sun

Erschienen in: Polymer Bulletin | Ausgabe 8/2020

Einloggen

Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.

search-config
loading …

Abstract

Silk fibroin (SF) from the Bombyx mori silkworm is an excellent biopolymer due to its biocompatibility and degradation. Self-assembled SF nanoparticles loaded with erlotinib are very promising method to treat breast cancer. The size of SF nanoparticles was about 219 ± 5.7 nm, the dispersion coefficient was about 0.2 ± 0.03, the encapsulation efficiency was 7.7%, and the drug loading rate was 1.54%. The characteristics of SF nanoparticles were studied by Fourier transform infrared and transmission electron microscope. The cell experiments confirmed that SF nanoparticles had lower and extended cytotoxicity than that of free drugs. These results showed that self-assembled, biocompatible, and biodegradable SF nanoparticles loaded with erlotinib will have potential prospects in the treatment of breast cancer.
Vorheriger Artikel Effect of hollow glass microsphere on the flame retardancy and combustion behavior of intumescent flame retardant polypropylene composites
Nächster Artikel Study of antimicrobial and physicochemical properties of LDPE/propolis extruded films

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Jetzt informieren

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 390 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe




 

Jetzt Wissensvorsprung sichern!

Jetzt informieren
Literatur
1.
Liao WS, Ho Y, Lin YW, Naveen Rai E, Liu KK, Chen C, Zhou XZ, Lu KP, Chao JI (2019) Targeting EGFR of triple negative breast cancer enhances the therapeutic efficacy of paclitaxel and cetuximab-conjugated nanodiamond nanocomposite. Acta Biomater 86:395–405PubMedCrossRef
2.
Liu X, Zhang X, Zhu M, Lin G, Liu J, Zhou Z, Tian X, Pan Y (2017) PEGylated Au@Pt nanodendrites as novel theranostic agents for computed tomography imaging and photothermal/radiation synergistic therapy. ACS Appl Mater Interfaces 9:279–285PubMedCrossRef
3.
Deng Y, Tian X, Lu S, Xie M, Hu H, Zhang R, Lv F, Cheng L, Gu H, Zhao Y, Pan Y (2018) Fabrication of multifoliate PtRu bimetallic nanocomplexes for computed tomography imaging and enhanced synergistic thermoradiotherapy. ACS Appl Mater Interfaces 10:31106–31113PubMedCrossRef
4.
Zhu J, Yang F, He F, Tian X, Tang S, Chen X (2015) A tubular gelatin scaffold capable of the time-dependent controlled release of epidermal growth factor and mitomycin C. Colloids Surf B Biointerfaces 135:416–424PubMedCrossRef
5.
6.
Tian X, Liu S, Zhu J, Qian Z, Bai L, Pan Y (2019) Biofunctional magnetic hybrid nanomaterials for theranostic applications. Nanotechnology 30:032002PubMedCrossRef
7.
Tian J, Chen J, Ge C (2016) Synthesis of PEGylated ferrocene nanoconjugates as the radiosensitizer of cancer cells. Bioconjug Chem 27:1518–1524PubMedCrossRef
8.
Jia X, Jia L (2012) Nanoparticles improve biological functions of phthalocyanine photosensitizers used for photodynamic therapy. Curr Drug Metab 13:1119–1122PubMedCrossRef
9.
Pore N, Liu S, Haas-Kogan DA, O’Rourke DM, Maity A (2003) PTEN mutation and epidermal growth factor receptor activation regulate vascular endothelial growth factor (VEGF) mRNA expression in human glioblastoma cells by transactivating the proximal VEGF promoter. Cancer Res 63:236–241PubMed
10.
Maity A, Pore N, Lee J, Solomon D, O’Rourke D (2000) Epidermal growth factor receptor (EGFR) transcriptionally upregulates VEGF expression in human glioblastoma cells via a pathway involving PI (3) kinase and distinct from that induced by hypoxia. Cancer Res 60:5879–5886PubMed
11.
Zhang Y, Schwerbrock NM, Rogers AB, Kim WY, Huang L (2013) Co-delivery of VEGF siRNA and gemcitabine monophosphate in a single nanoparticle formulation for effective treatment of NSCLC. Mol Ther 21:1559–1569PubMedPubMedCentralCrossRef
12.
Chen Q, Xu L, Chen J, Yang Z, Liang C, Yang Y, Liu Z (2017) Tumor vasculture normalization by orally fed erlotinib to modulate the tumor microenvironment for enhanced cancer nanomedicine and immunotherapy. Biomaterials 148:69–80PubMedCrossRef
13.
Xue B, Zhang Y, Xu M, Wang C, Huang J, Zhang H, Meng S, Xie M, Tao A, Li X (2019) Curcumin-silk fibroin nanoparticles for enhanced anti-candida albicans activity in vitro and in vivo. J Biomed Nanotechnol 15(4):769–778PubMedCrossRef
14.
Patil S, Singh N (2018) Antibacterial silk fibroin scaffolds with green synthesized silver nanoparticles for osteoblast proliferation and human mesenchymal stem cell differentiation. Colloids Surf B Biointerfaces 176:150–155PubMedCrossRef
15.
Takeuchi I, Shimamura Y, Kakami Y, Kameda T, Hattori K, Miura S, Shirai H, Okumura M, Inagi T, Terada H, Makino K (2019) Transdermal delivery of 40-nm silk fibroin nanoparticles. Colloids Surf B Biointerfaces 175:564–568PubMedCrossRef
16.
Yang P, Dong Y, Huang D, Zhu C, Liu H, Pan X, Wu C (2018) Silk fibroin nanoparticles for enhanced bio-macromolecule delivery to the retina. Pharm Dev Technol 24(5):575–583CrossRef
17.
Tan M, Liu W, Liu F, Zhang W, Gao H, Cheng J, Chen Y, Wang Z, Cao Y, Ran H (2019) Silk fibroin-coated nanoagents for acidic lysosome targeting by a functional preservation strategy in cancer chemotherapy. Theranostics. 9(4):961–973PubMedPubMedCentralCrossRef
18.
Li H, Tian J, Wu A, Wan J, Ge C, Sun Z (2016) Self-assembled silk fibroin nanoparticles loaded with binary drugs in the treatment of breast carcinoma. Int J Nanomed 11:4373–4380CrossRef
19.
Seib FP, Herklotz M, Burke KA, Maitz MF, Werner C, Kaplan DL (2014) Multifunctional silk–heparin biomaterials for vascular tissue engineering applications. Biomaterials 35:83–91PubMedCrossRef
20.
Yan S, Zhang Q, Wang J (2013) Silk fibroin/chondroitin sulfate/hyaluronic acid ternary scaffolds for dermal tissue reconstruction. Acta Biomater 9:6771–6782PubMedCrossRef
21.
Shi P, Teh TK, Toh SL, Goh JC (2013) Variation of the effect of calcium phosphate enhancement of implanted silk fibroin ligament bone integration. Biomaterials 34:5947–5957PubMedCrossRef
22.
Zhang W, Chen J, Tao J (2013) The promotion of osteochondral repair by combined intra-articular injection of parathyroid hormone related protein and implantation of a bi-layer collagen-silk scaffold. Biomaterials 34:6046–6057PubMedCrossRef
23.
Gu Y, Zhu J, Xue C (2014) Chitosan/silk fibroin-based, Schwann cell derived extracellular matrix-modified scaffolds for bridging rat sciatic nerve gaps. Biomaterials 35:2253–2263PubMedCrossRef
24.
Ren YJ, Zhou ZY, Liu BF, Xu QY, Cui FZ (2009) Preparation and characterization of fibroin/hyaluronic acid composite scaffold. Int J Biol Macromol 44:372–378PubMedCrossRef
25.
Li M-Y, Zhao Y, Tong T (2013) Study of the degradation mechanism of Chinese historic silk (Bombyx mori) for the purpose of conservation. Polym Degrad Stab 98:727–735CrossRef
26.
Roh YG, Shin SW, Kim SY, Kim S, Lim YT, Oh BK, Um SH (2019) Protein nanoparticle fabrication for optimized reticuloendothelial system evasion and tumor accumulation. Langmuir 35(11):3992–3998PubMedCrossRef
27.
Li Y, Zhang H (2019) Nanoparticle-based drug delivery systems for enhanced tumor-targeting treatment. J Biomed Nanotechnol 15(1):1–27PubMedCrossRef
28.
Gaio E, Conte C, Esposito D, Miotto G, Quaglia F, Moret F, Reddi E (2018) Co-delivery of docetaxel and disulfonate tetraphenyl chlorin in one nanoparticle produces strong synergism between chemo- and photodynamic therapy in drug-sensitive and -resistant cancer cells. Mol Pharm 15(10):4599–4611PubMedCrossRef
29.
Seib FP, Jones GT, Rnjak-Kovacina J, Lin Y, Kaplan DL (2013) pH-dependent anticancer drug release from silk nanoparticle. Adv Healthc Mater 2(12):1606–1611PubMedCrossRef
30.
Mao B, Liu C, Zheng W, Li X, Ge R, Shen H, Guo X, Lian Q, Shen X, Li C (2018) Cyclic cRGDfk peptide and Chlorine6 functionalized silk fibroin nanoparticles for targeted drug delivery and photodynamic therap. Biomaterials 161:306–320PubMedCrossRef
Metadaten
Titel
Erlotinib–silk fibroin nanoparticles in inhibiting tumor
verfasst von
Hui Li
Hao Qiu
Jiamin Wang
Ziling Sun
Publikationsdatum
25.09.2019
Verlag
Springer Berlin Heidelberg
Erschienen in
Polymer Bulletin / Ausgabe 8/2020
Print ISSN: 0170-0839
Elektronische ISSN: 1436-2449
DOI
https://doi.org/10.1007/s00289-019-02946-1

Weitere Artikel der Ausgabe 8/2020

Polymer Bulletin 8/2020 Zur Ausgabe

Original Paper

Effect of cationic and anionic clays as supports for styrene polymerization initiated by metallocenes/MAO catalytic system

Original Paper

Thermoresponsive cryogels of poly(2-hydroxyethyl methacrylate-co-N-isopropyl acrylamide) (P(HEMA-co-NIPAM)): fabrication, characterization and water sorption study

Original Paper

Effects of cellulose nanocrystal polymorphs and initial state of hydrogels on swelling and drug release behavior of alginate-based hydrogels

Original Paper

One-pot synthesis of molecular-imprinted membrane for selective extraction of caffeic acid

Original Paper

Effect of surfactant on the swelling and mechanical behavior of NIPAM-based terpolymer

Original Paper

Study of antimicrobial and physicochemical properties of LDPE/propolis extruded films

Premium Partner

    Marktübersichten

    Die im Laufe eines Jahres in der „adhäsion“ veröffentlichten Marktübersichten helfen Anwendern verschiedenster Branchen, sich einen gezielten Überblick über Lieferantenangebote zu verschaffen. 

    Zur Marktübersicht
    Bildnachweise