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01.02.2012 | Research Paper

Evaluation of an oral carrier system in rats: bioavailability and gastrointestinal absorption properties of curcumin encapsulated PBCA nanoparticles

verfasst von: Min Sun, Lixia Zhao, Chenyu Guo, Fengliang Cao, Huanlei Chen, Liyan Zhao, Qi Tan, Xiuqing Zhu, Fanping Zhu, Tingting Ding, Yingjie Zhai, Guangxi Zhai

Erschienen in: Journal of Nanoparticle Research | Ausgabe 2/2012

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Abstract

A new oral delivery system, polybutylcyanoacrylate nanoparticles (PBCNs), was introduced to improve the oral bioavailability of curcumin (CUR), a poorly soluble drug. The formulation was optimized by orthogonal design and the optimal PBCNs loading CUR exhibited a spherical shape under transmission electron microscopy with a range of 40–400 nm. Physicochemical state of CUR in PBCN was investigated by X-ray diffraction and the possible structure changes occurring in CUR after conjugating with polybutylcyanoacrylate were studied with FTIR. The results indicated that CUR in PBCN was in a non-crystalline state and CUR was encapsulated in PBCN without chemical reaction. The oral pharmacokinetic study was conducted in rats and the relative bioavailability of CUR encapsulated PBCNs to the crude CUR was more than 800%. The in situ absorption experiment in rat intestine indicated the absorption was first order with passive diffusion mechanism. The absorption results in various segments of intestine showed that the main absorption sites were ileum and colon. It can be concluded that PBCNs as an oral carrier can significantly improve the oral absorption of a poorly soluble drug.

Vorheriger Artikel Immobilization of platinum nanoparticles on 3,4-diaminobenzoyl-functionalized multi-walled carbon nanotube and its electrocatalytic activity

Nächster Artikel Biotinylated chitosan-based SPIONs with potential in blood-contacting applications

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Titel: Evaluation of an oral carrier system in rats: bioavailability and gastrointestinal absorption properties of curcumin encapsulated PBCA nanoparticles
verfasst von: Min Sun
Lixia Zhao
Chenyu Guo
Fengliang Cao
Huanlei Chen
Liyan Zhao
Qi Tan
Xiuqing Zhu
Fanping Zhu
Tingting Ding
Yingjie Zhai
Guangxi Zhai
Publikationsdatum: 01.02.2012
Verlag: Springer Netherlands
Erschienen in: Journal of Nanoparticle Research / Ausgabe 2/2012
Print ISSN: 1388-0764
Elektronische ISSN: 1572-896X
DOI: https://doi.org/10.1007/s11051-011-0705-4

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