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Polymer Bulletin
Erschienen in: Polymer Bulletin 7/2017

16.11.2016 | Original Paper

Gum acacia polysaccharide-based pH sensitive gels for targeted delivery of neridronate

verfasst von: B. A. Aderibigbe, Suprakas Sinha Ray

Erschienen in: Polymer Bulletin | Ausgabe 7/2017

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Abstract

The preparation of polysaccharide-based gels from a combination of natural and synthetic polymers results in polymer networks with unique physicochemical properties. Polysaccharide-based gels were prepared from a combination of gum acacia, a polysaccharide, and synthetic polymers using the free radical polymerization technique. The gels were characterized by XRD, DSC, SEM, and FTIR. The swelling abilities of the gels were performed at pH 1.2 and 7.4. Release kinetic studies of neridronate from the prepared gels were performed and the release mechanism was found to be super case transport II at pH 1.2 and pH 7.4. The gels were pH sensitive and the release profile of neridronate from the gels network was influenced by the degree of cross-linking of their network and pH. The preliminary results suggest that these gels are promising devices for targeted delivery of neridronate to the gastrointestinal region.
Vorheriger Artikel Structural, optical and electrical properties of polypyrrole in an ionic liquid
Nächster Artikel Polyaniline-poly(2-acrylamido-2-methyl-1-propanesulfonic acid) electrodes coated on plasma-treated thiolene-based polymer substrates for high-efficiency electrochemical capacitors

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Metadaten
Titel
Gum acacia polysaccharide-based pH sensitive gels for targeted delivery of neridronate
verfasst von
B. A. Aderibigbe
Suprakas Sinha Ray
Publikationsdatum
16.11.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
Polymer Bulletin / Ausgabe 7/2017
Print ISSN: 0170-0839
Elektronische ISSN: 1436-2449
DOI
https://doi.org/10.1007/s00289-016-1857-2

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