Skip to main content
main-content

2019 | Buch

Keratin as a Protein Biopolymer

Extraction from Waste Biomass and Applications

share
TEILEN
insite
SUCHEN

Über dieses Buch

This book provides information about the sources, structure, and properties of keratin as well as its applications. The extraction from different biomass sources (e.g. feathers, hairs, nails, horn, hoof, and claws) as well as the characterization methods of these extracted materials are explained. The development of bioproducts from keratins is challenging and limited since they are neither soluble in polar solvents nor in non-polar solvents. Therefore, the utilization of different microorganisms for the degradation of keratin is also discussed.
The main aim of this book is to highlight the unique features of keratin and to update readers with the possible prospects to develop various value-added products from keratins. The book is highly interesting to researchers working in industry and academia on bioproducts, tissue engineering, biocomposites, biofilm, and biofibers.

Inhaltsverzeichnis

Frontmatter
Chapter 1. Keratin: An Introduction
Abstract
What is keratin? And why to use the keratin? Well known that protein is a part of every cell in living organism’s body which plays many different roles to keep living things alive and healthy. The importance of protein for the growth and repair of muscles, bones, skin, tendons, ligaments, hair, eyes, and other tissues is proven since a very long time. Proteins also exist in the form of enzymes and hormones needed for metabolism, digestion, and other important processes. Natural proteins are purified from natural sources. Keratin is among the most copious proteins found associated with the body of reptiles, birds, and mammals. It is a structural constituent of nail, wool, feathers, and hoofs which offers strength to body and muscles. Nowadays, the keratin-rich waste biomass produced from poultry and meat industry imposes serious threat to environment and living beings. We need to explore various techniques and methods for the extractions and use of keratin from waste biomass. From the industrial point of view, keratin is a useful product in the medical, pharmaceutical, cosmetic, and biotechnological industries. Materials obtained from keratin may be converted into porous foam of different sponges, shapes, coatings, mats, microfibers, gels, and materials of high molecular weight. In this chapter, we briefly describe the various sources, properties, and structures of keratin.
Swati Sharma, Arun Gupta, Ashok Kumar
Chapter 2. Keratin Production and Its Applications: Current and Future Perspective
Abstract
Keratin is a global class of biological material, which represents a group of cysteine-rich filament-forming proteins. They serve as a shielding layer for the epidermal appendages like nails, claws, beak, hair, wool, horns, and feathers. These proteins are further subdivided into two different class based on their secondary structure: α-keratin and β-keratin. Keratin is insoluble in hot or cold water; this unique property helps to prevent their digestion by proteolytic enzymes. Additionally, their complex hierarchical-like filament-matrix structure at nanoscale and the polypeptide chains create a robust wall for protection against heat stress, pathogen invasions (particularly through skin), mechanical damage, etc. In this review, we are trying to attempt a linear focus in the direction of structure, function, extraction of keratin, and its industrial applications.
Anshuman Shah, Shaily Tyagi, Ram Naresh Bharagava, Dalel Belhaj, Ashok Kumar, Gaurav Saxena, Ganesh Dattatraya Saratale, Sikandar I. Mulla
Chapter 3. Extraction and Characterization of Keratin from Different Biomasses
Abstract
Keratin is a high-sulphur content protein, highly abundant in nature since it is the major component of feathers, hair, wool, horns and nails. In recent years, keratin-based materials have received great consideration due to its unique features in terms of ability to absorb heavy metals and other toxic compounds, thus resulting particularly useful for water and air purification. Moreover, due to its intrinsic efficacy in promoting cells growth, along with its ability to encapsulate both hydrophobic and hydrophilic drugs, keratin has been increasingly studied for the preparation of a wide range of bio-medical devices, especially in the field of tissue engineering and controlled drug delivery. Extraction of keratin from low-cost biomasses deriving from food industry by-products (especially slaughterhouse, dairy and poultry industry) is a challenging process hampered by the presence of a high content of disulphide bonds that bestow the protein with high resistance to chemical, enzymatic and thermal treatments. Thus, the large-scale use of keratin strongly depends on the development of cost-effective and time-efficient extraction methods. This chapter gives an overview on the availability of different keratinous biomasses and examines the various extraction methods proposed in the literature, underlining their advantages and limitations. Moreover, a detailed comparison between the chemical–physical properties of keratins obtained from different biomasses is here reported.
Claudia Vineis, Alessio Varesano, Greta Varchi, Annalisa Aluigi
Chapter 4. Keratin Processing
Abstract
This chapter deals with the various ways in which keratin (extracted from different sources) can be processed to obtain different types of products. In the first section, solvents and polymers that must be employed to make this natural biopolymer usable are discussed. Sections 25 are mainly oriented in the transformations of keratin in processes such as spinning, electrospinning, casting, foaming, and freeze-drying. In addition, some products (fibers, nanofibers, films, coating, and sponge) and applications (filtration, adsorption, and scaffolds) corresponding to the procedures mentioned above are reported. The last section is related to the chemical treatments (e.g., crosslinking) applied to keratin to modify its properties.
Diego Omar Sanchez Ramirez, Riccardo Andrea Carletto, Francesca Truffa Giachet
Chapter 5. Degradation of Keratin Biomass by Different Microorganisms
Abstract
Keratins are insoluble, fibrous, and structural proteins that are present in the epidermis and its appendages and these include feather, hair, wool, nail, hoof, and horns. Keratins adhere epidermal cells to one another and provide protection on the skin. They are structurally stabilized by their tightly packed peptide chains and the existence of several cross-linkages by disulphide bonds, hydrogen bonding, and hydrophobic interactions. Keratin-containing materials are generated abundantly as by-products of agro-industrial processing and constitute nuisance in the environment as a result of their recalcitrance to degradation by regular proteolytic enzymes like pepsin, trypsin, and papain. The traditional physical and chemical techniques for their treatment are expensive, energy consuming, can damage some essential amino acids, and non-environmentally benign. However, degradation by a variety of microorganisms had proven to be a viable alternative means of keratin treatment. A vast variety of bacteria, fungi, and actinomycetes have been recognized as keratin degraders. They degrade keratins mainly with their keratinases, which sometimes act synergistically with other enzymes like disulfide reductases and cysteine dioxygenase for effective degradation of keratins. The microbial keratinases hydrolyze keratins into soluble proteins, peptides, and amino acids. They are utility enzymes with very diverse biotechnological applications. Biodegradation of keratin-rich wastes by microorganisms is therefore an efficient, cheap, and eco-friendly method of waste management and production of products of high biotechnological value. The present review examines the trends in the role of microorganisms for the biotechnological treatment of keratin-rich wastes.
I. A. Adelere, A. Lateef
Chapter 6. Keratin as a Biopolymer
Abstract
Keratin has recently gained a lot of limelight among various proteins. Keratin is a renewable, sustainable, biocompatible, and biodegradable bioresource, and these characteristics make it a promising candidate for diverse applications. It is a fibrous protein mainly found in feathers, hair, wool, animal claws, and fingernails. It is one of the key structural materials present in the outer layer of human skin, hence having a lot of applications in developing cosmetics. As an effective biopolymer, keratin containing a different sequence of amino acids have several functional properties and applications. One of the major applications is to be used as a biosorbent in wastewater treatment, which is attributed to expose functional groups present in the highly folded network of amino acids and their modification that improves the reactivity as adsorbent. Keratin-based nanocomposites are used in tissue engineering as it can impart characteristics like increased regeneration and hydration. Another great application in the field of biomedical engineering is drug delivery using keratin-based carriers. Thermoplastics developed from keratins can be used as films in biomedical application. This chapter will highlight the major applications of keratin proteins in detail.
Sarthak Saha, Muhammad Arshad, Muhammad Zubair, Aman Ullah
Chapter 7. Keratin-Based Biofilms, Hydrogels, and Biofibers
Abstract
Keratin is a nearly ubiquitous, filamentous protein with high amounts of sulfur molecules. The sulfur content of keratin, resulting from a high proportion of cystine residues, is significant to the form and function of keratin in naturally occurring structures and chemically synthesized biomaterials. The intrinsic physical and chemical properties of keratin have led to the development of a variety of biotechnical and materials science applications. The exploitation of the biochemical and physical properties of this abundant and naturally occurring protein has led to numerous novel uses including drug delivery, dental implants, wound dressings, and food packaging. This chapter describes the intrinsic properties of keratin, as well as the production and use of keratin-based biofilms and biofibers.
James McLellan, Starla G. Thornhill, Spencer Shelton, Manish Kumar
Chapter 8. Keratin-Based Biotechnological Applications
Abstract
The present chapter is aimed towards giving an overview of the applications of keratin as a potential biomaterial substitute in the field of biotechnology. Keratin is a fibrous protein and considered as biomaterial due to its biocompatible and biodegradable characteristics. Its use as biopolymer has been the subject of intense investigation over the past few years. Wool, feather, horn and hooves, etc., are strong in terms of mechanical strength due to the presence of keratin. But once keratin is extracted from natural sources then, it becomes poor in mechanical properties. So, the blending of keratin with other biopolymer can improve the material properties like strength, flexibility, and water vapor permeability. The malleable nature of keratin proves its biotechnological applications such as tissue engineering scaffold, green composites, green cement, bioplastic, etc. The functional groups and chemical structures of keratin govern its properties and morphology, which gives an opportunity to control the design of desired molecular structure for various applications, and varies from industrial to the biotechnological field. Recently, the biodegradable keratin-based biopolymers have gained considerable importance in the medical field as they avoid additional surgery to remove the implants and lack of medical waste burden. Thus, much attention needs to be undertaken on the development of composite biomaterial derived from keratin.
Kush Kumar Nayak, Piyush Parkhey, Bidyut Mazumdar
Metadaten
Titel
Keratin as a Protein Biopolymer
herausgegeben von
Ph.D. Swati Sharma
Prof. Dr. Ashok Kumar
Copyright-Jahr
2019
Electronic ISBN
978-3-030-02901-2
Print ISBN
978-3-030-02900-5
DOI
https://doi.org/10.1007/978-3-030-02901-2

Premium Partner

    Marktübersichten

    Die im Laufe eines Jahres in der „adhäsion“ veröffentlichten Marktübersichten helfen Anwendern verschiedenster Branchen, sich einen gezielten Überblick über Lieferantenangebote zu verschaffen.