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Colloid and Polymer Science

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29.08.2017 | Original Contribution

Magnetite/poly(D,L-lactide-co-glycolide) and hydroxyapatite/poly(D,L-lactide-co-glycolide) prepared by w/o/w emulsion technique for drug carrier: physical characteristic of composite nanoparticles

verfasst von: Kittima Bootdee, Brian P. Grady, Manit Nithitanakul

Erschienen in: Colloid and Polymer Science | Ausgabe 10/2017

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Abstract

Poly(D,L-lactide-co-glycolide) (PLGA) with encapsulated hydrophobic magnetite (Fe₃O₄) nanoparticles or hydroxyapatite (HAp) nanoparticles were prepared by the w/o/w emulsion technique. The weight ratios of nanoparticles (Fe₃O₄ or HAp) to PLGA and polymer molecular weight were varied in the oil phase and the properties of the composite nanoparticles were studied. The final weight percent of nanoparticles in the spherical PLGA particles varied from ~ 5 to 60 wt%. Hydrodynamic diameters of the composite nanoparticles as measured by dynamic light scattering (DLS) were found to decrease with decreasing polymer molecular weight and were independent of nanoparticle loading. Particle sizes measured from TEM were smaller by almost a factor of two vs. those obtained from DLS. The zeta potentials of the particles were about − 23 mV, independent of polymer molecular weight and nanoparticle loading within statistical significance. In vitro cytotoxicity tests show a high level of cytocompatibility suggesting satisfactory biocompatibility for biomedical applications.

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Titel: Magnetite/poly(D,L-lactide-co-glycolide) and hydroxyapatite/poly(D,L-lactide-co-glycolide) prepared by w/o/w emulsion technique for drug carrier: physical characteristic of composite nanoparticles
verfasst von: Kittima Bootdee
Brian P. Grady
Manit Nithitanakul
Publikationsdatum: 29.08.2017
Verlag: Springer Berlin Heidelberg
Erschienen in: Colloid and Polymer Science / Ausgabe 10/2017
Print ISSN: 0303-402X
Elektronische ISSN: 1435-1536
DOI: https://doi.org/10.1007/s00396-017-4185-7

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