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Polymer Bulletin
Erschienen in: Polymer Bulletin 11/2016

29.03.2016 | Original Paper

Fabrication of chitosan/MWCNT nanocomposite as a carrier for 5-fluorouracil and a study of the cytotoxicity of 5-fluorouracil encapsulated nanocomposite towards MCF-7

verfasst von: E. A. K. Nivethaa, S. Dhanavel, V. Narayanan, A. Stephen

Erschienen in: Polymer Bulletin | Ausgabe 11/2016

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Abstract

Polymer matrix type chitosan/multiwalled carbon nanotube nanocomposite and 5-fluorouracil encapsulated chitosan/multiwalled carbon nanotube nanocomposite have been successfully synthesized by the chemical method. The prepared nanocomposites were characterized using XRD, FTIR, UV, HRTEM, SAED and the release profile of 5-FU from the nanocomposite system has been evaluated. The XRD pattern of the chitosan/multiwalled carbon nanotube nanocomposite shows the presence of planes corresponding to both chitosan and MWCNT and that of drug-encapsulated nanocomposite shows the presence of peaks of 5-fluorouracil in addition to the other two moieties. Binding of carbon nanotube to the NH2 and OH groups of chitosan has been elucidated using FTIR. The encapsulation of 5-fluorouracil to the nanocomposite has been verified using elemental mapping and SAED studies apart from XRD. The encapsulation efficiency of 5-FU into the nanocomposite has been calculated and is 97 %. The cytotoxicity of the nanocomposite towards the breast cancer cell line (MCF-7) has been studied.
Vorheriger Artikel The influence of molecular weight on high shear rate macroscopic rheological properties of polybutene-1 melts through rubber-processing analyzer
Nächster Artikel Synthesis and characterization of cardo poly(ether-ester)s containing 1,1-bis (4-hydroxyphenyl) cyclohexane in the main chain

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Metadaten
Titel
Fabrication of chitosan/MWCNT nanocomposite as a carrier for 5-fluorouracil and a study of the cytotoxicity of 5-fluorouracil encapsulated nanocomposite towards MCF-7
verfasst von
E. A. K. Nivethaa
S. Dhanavel
V. Narayanan
A. Stephen
Publikationsdatum
29.03.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
Polymer Bulletin / Ausgabe 11/2016
Print ISSN: 0170-0839
Elektronische ISSN: 1436-2449
DOI
https://doi.org/10.1007/s00289-016-1651-1

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