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23.11.2017 | Original Paper

Preparation and characterization of chitosan–poly(vinyl alcohol)–neomycin sulfate films

verfasst von: Irina Paula Merlusca, Doina Simona Matiut, Gabriela Lisa, Mihaela Silion, Luiza Gradinaru, Stefan Oprea, Ionel Marcel Popa

Erschienen in: Polymer Bulletin | Ausgabe 9/2018

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Abstract

The aim of our study was obtaining chitosan–poly(vinyl alcohol)–neomycin sulfate films (Cs–PVA–Ne) by using solvent casting technique and the characterization of the products. The films were analyzed by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy, thermogravimetry (TG and DTG), differential scanning calorimetry (DSC), contact angle (CA) measurements, mechanical, and antibacterial activity tests. FTIR and DSC analysis demonstrated that interaction between Cs, PVA, and Ne took place. Static water CA measurements showed an improvement in the hydrophilicity of the Cs–PVA–Ne films. Also, the drug-loaded films proved to have fairly good mechanical strength and significant effects against Staphylococcus aureus and Escherichia coli. The unloaded films show minimum bacterial inhibition (~ 10.00 mm) compared to drug-loaded films (~ 30.00 mm). The bacterial inhibition was higher in all the cases of S. aureus than E. coli. Furthermore, PVA was found to improve the films properties. Due to their physical–chemical and mechanical features and the excellent antibacterial properties, the obtained Cs–PVA–Ne films are suitable for their use as wound-dressing materials.

Vorheriger Artikel Influence of thiol groups on the ethylene adsorption and conductivity properties of the modified porous clay heterostructures (PCHS) using as ethylene scavenger in smart packaging

Nächster Artikel Antibacterial silver nanoparticle coating on oxo-biodegradable polyethylene film surface using modified polyethylene and corona discharge

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Li C, Fu R, Yu C, Li Z, Guan H, Hu D, Zhao D, Lu L (2013) Silver nanoparticle/chitosan oligosaccharide/poly(vinyl alcohol) nanofibers as wound dressings: a preclinical study. Int J Nanomed 8:4131–4145. https://doi.org/10.2147/IJN.S51679 CrossRef

Kamoun EA, Chen X, MohyEldin MS, Kenawy ES (2015) Crosslinked poly(vinyl alcohol) hydrogels for wound dressing applications: a review of remarkably blended polymers. Arab J Chem 8(1):1–14. https://doi.org/10.1016/j.arabjc.2014.07.005 CrossRef

Kokabi M, Sirousazar M, Hassan ZM (2007) PVA–clay nanocomposite hydrogels for wound dressing. Eur Polym J 43:773–781. https://doi.org/10.1016/j.eurpolymj.2006.11.030 CrossRef

Kiselioviene S, Baniukaitiene O, Harkavenko V, Babenko NA, Liesiene J (2016) Cellulose hydrogel sheets for wound dressings. Cellulose Chem Technol 50(9–10):915–923

Kamoun EA, Kenawy ERS, Chen X (2017) A review on polymeric hydrogel membranes for wound dressing applications: PVA-based hydrogel dressings. J Adv Res 8(3):217–233. https://doi.org/10.1016/j.jare.2017.01.005 CrossRefPubMedPubMedCentral

Madaghiele M, Demitri C, Sannino A, Ambrosio L (2014) Polymeric hydrogels for burn wound care: advanced skin wound dressings and regenerative templates. Burns Trauma. https://doi.org/10.4103/2321-3868.143616 CrossRefPubMedPubMedCentral

Darwhekar G, Jain DK, Choudhary A (2012) Elastic liposomes for delivery of neomycin sulphate in deep skin infection. Asian J Pharm Sci 7:230–240

Nitanan T, Akkaramongkolporn P, Rojanarata T, Ngawhirunpat T, Opanasopit P (2013) Neomycin-loaded poly (styrene sulfonic acid-co-maleic acid) (PSSA-MA)/polyvinyl alcohol (PVA) ion exchange nanofibers for wound dressing materials. Int J Pharm 448(1):71–78. https://doi.org/10.1016/j.ijpharm.2013.03.011 CrossRefPubMed

Straccia MC, d’Ayala GG, Romano I, Oliva A, Laurienzo P (2015) Alginate hydrogels coated with chitosan for wound dressing. Mar Drugs 13(5):2890–2908. https://doi.org/10.3390/md13052890 CrossRefPubMedPubMedCentral

10.

Bernabé P, Peniche C, Argüelles-Monal W (2005) Swelling behavior of chitosan/pectin polyelectrolyte complex membranes. Effect of thermal cross-linking. Polym Bull 55:367–375. https://doi.org/10.1007/s00289-005-0439-5 CrossRef

11.

Ali NA, Al-Ajaj EA, Noori FTM (2013) Effect of nanoSiO2 additive of some mechanical and water absorption of polyvinyl alcohol/chitosan blends. ABC J Adv Res 1:36–41. https://doi.org/10.18034/abcjar.v2i1.426 CrossRef

12.

Părpăriţă E, Cheaburu CN, Paţachia SF, Vasile C (2014) Polyvinyl alcohol/chitosan/montmorillonite nanocomposites preparation by freeze/thaw cycles and characterization. Acta Chemica Iasi 22(2):75–96. https://doi.org/10.2478/achi-2014-0008 CrossRef

13.

Kouchak M, Ameri A, Naseri B, Kargar Boldaji S (2014) Chitosan and polyvinyl alcohol composite films containing nitrofurazone: preparation and evaluation. Iran J Basic Med Sci 17(1):14–20PubMedPubMedCentral

14.

Pereira VA Jr, Queiroz de Arruda IN, Stefani R (2015) Active chitosan/PVA films with anthocyanins from Brassica oleraceae (red cabbage) as time-temperature indicators for application in intelligent food packaging. Food Hydrocoll 43:180–188. https://doi.org/10.1016/j.foodhyd.2014.05.014 CrossRef

15.

Nand AV, Rohindra DR, Khurma JR (2007) Characterization of genipin crosslinked hydrogels composed of chitosan and partially hydrolyzed poly(vinyl alcohol). e-Polymers. https://doi.org/10.1515/epoly.2007.7.1.402 CrossRef

16.

Masti S, Kasai D, Mudigoudra B, Chougale R (2016) Effect of gum acacia (GA) on tensile properties of biodegradable chitosan (CS)/poly(vinyl alcohol) (PVA) polymer blend films. Res J Mater Sci 4(5):5–8

17.

Chetouani A, Elkolli M, Bounekhel M, Benachour D (2017) Chitosan/oxidized pectin/PVA blend film: mechanical and biological properties. Polym Bull 74:4297–4310. https://doi.org/10.1007/s00289-017-1953-y CrossRef

18.

Maji P, Gandhi A, Jana S, Maji N (2013) Preparation and characterization of maleic anhydride cross-linked chitosan–polyvinyl alcohol hydrogel matrix transdermal patch. J Pharm Sci Tech 2(2):62–67

19.

Abbaspour M, Makhmalzadeh BS, Rezaee B, Shoja S, Ahangari Z (2015) Evaluation of the antimicrobial effect of chitosan/polyvinyl alcohol electrospun nanofibers containing mafenide acetate. Jundishapur J Microbiol 8(10):e24239. https://doi.org/10.5812/jjm.24239 CrossRefPubMedPubMedCentral

20.

Elbarbary AM, El-Sawy NM (2017) Radiation synthesis and characterization of polyvinyl alcohol/chitosan/silver nanocomposite membranes: antimicrobial and blood compatibility studies. Polym Bull 74(1):195–212. https://doi.org/10.1007/s00289-016-1708-1 CrossRef

21.

Fan L, Yang H, Yang J, Peng M, Hu J (2016) Preparation and characterization of chitosan/gelatin/PVA hydrogel for wound dressings. Carbohydr Polym 146(1):427–434. https://doi.org/10.1016/j.carbpol.2016.03.002 CrossRefPubMed

22.

Chen CK, Huang SC (2016) Preparation of reductant-responsive N-maleoyl-functional chitosan/poly(vinyl alcohol) nanofibers for drug delivery. Mol Pharm 13(12):4152–4167. https://doi.org/10.1021/acs.molpharmaceut.6b00758 CrossRefPubMed

23.

Das S, Subuddhi U (2016) Controlled and targeted delivery of diclofenac sodium to the intestine from pH-responsive chitosan/poly(vinyl alcohol) interpenetrating polymeric network hydrogels. Polym Sci Ser A 58(2):154–166. https://doi.org/10.1134/S0965545X16020048 CrossRef

24.

Wang Q, Du YM, Fan LH (2005) Properties of chitosan/poly(vinyl alcohol) films for drug-controlled release. J Appl Polym Sci 96:808–813. https://doi.org/10.1002/app.21518 CrossRef

25.

Hashemnia S, Mokhtari Z, Tashkhourian J, Moosavi-Movahedi AA (2015) Effect of covalent attachment of neomycin on conformational and aggregation properties of catalase. Indian J Biochem Biophys 52:189–195PubMed

26.

Alhosseini SN, Moztarzadeh F, Mozafari M, Asgari S, Dodel M, Samadikuchaksaraei A, Kargozar S, Jalali N (2012) Synthesis and characterization of electrospun polyvinyl alcohol nanofibrous scaffolds modified by blending with chitosan for neural tissue engineering. Int J Nanomedicine 7:25–34. https://doi.org/10.2147/IJN.S25376 CrossRefPubMedPubMedCentral

27.

Abdelgawad AM, Hudson SM, Rojas OJ (2014) Antimicrobial wound dressing nanofiber mats from multicomponent (chitosan/silver-NPs/polyvinyl alcohol) systems. Carbohydr Polym 100:166–178. https://doi.org/10.1016/j.carbpol.2012.12.043 CrossRefPubMed

28.

Agnihotri S, Mukherji S, Mukherji S (2012) Antimicrobial chitosan–PVA hydrogel as a nanoreactor and immobilizing matrix for silver nanoparticles. Appl Nanosci 2:179–188. https://doi.org/10.1007/s13204-012-0080-1 CrossRef

29.

Berger J, Reist M, MayerJM Felt O, Gurny R (2004) Structure and interactions in chitosan hydrogels formed by complexation or aggregation for biomedical applications. Eur J Pharm Biopharm 57(1):35–52. https://doi.org/10.1016/S0939-6411(03),00160-7 CrossRefPubMed

30.

Costa ES Jr, Barbosa-Stancioli EF, Mansur AAP, Vasconcelos WL, Mansur HS (2009) Preparation and characterization of chitosan/poly(vinyl alcohol) chemically crosslinked blends for biomedical applications. Carbohydr Polym 76:472–481. https://doi.org/10.1016/j.carbpol.2008.11.015 CrossRef

31.

Liang S, Huang Q, Liu L, Yam KL (2009) Microstructure and molecular interaction in glycerol plasticized chitosan/poly (vinyl alcohol) blending films. Macromol Chem Phys 210:832–839. https://doi.org/10.1002/macp.200900053 CrossRef

32.

Szekalska M, Sosnowska K, Zakrzeska A, Kasacka I, Lewandowska A, Winnicka K (2017) The influence of chitosan cross-linking on the properties of alginate microparticles with metformin hydrochloride-in vitro and in vivo evaluation. Molecules 22:182. https://doi.org/10.3390/molecules22010182 CrossRef

33.

Chuang W-Y, Young T-H, Yao C-H, Chiu W-Y (1999) Properties of the poly(vinyl alcohol)/chitosan blend and its effect on the culture of fibroblast in vitro. Biomaterials 20:1479–1487. https://doi.org/10.1016/S0142-9612(99)00054-X CrossRefPubMed

34.

El-Hefian EA, Nasef MM, Yahaya AH (2011) Mechanical, thermal and surface investigations of chitosan/agar/PVA ternary blended films. E-J Chem 8(S1):S105–S112. https://doi.org/10.1155/2011/543587 CrossRef

35.

Deepak K, Saraswati M, Ravindra C, Gani R (2015) Preparation and characterization of binary blend films containing chitosan and vanillin. Am J Adv Drug Deliv 3(2):181–195

36.

El-Hefian EA, Nasef MM, Yahaya AH (2010) The preparation and characterization of chitosan poly (vinyl alcohol) blended films. E-J Chem 7(4):1212–1219. https://doi.org/10.1155/2010/626235 CrossRef

37.

Cascone MG, Maltinti S, Barbani N (1999) Effect of chitosan and dextran on the properties of poly(vinyl alcohol) hydrogels. J Mater Sci Mater Med 10:431–435. https://doi.org/10.1023/A:1008983215833 CrossRefPubMed

38.

Bahrami SB, Kordestani SS, Mirzadeh H, Mansoori P (2003) Poly (vinyl alcohol)-chitosan blends: preparation, mechanical and physical properties. Iran Polym J 12(2):139–146

39.

Paul D, Paul S, Roohpour N, Wilks M, Vadgama P (2013) Antimicrobial, mechanical and thermal studies of silver particle-loaded polyurethane. J Funct Biomater 4(4):358–375. https://doi.org/10.3390/jfb4040358 CrossRefPubMedPubMedCentral

40.

Ciobanu C, Tura V, Dorohoi DO, Ciobanu LC (2006) Biopoliuretani. Ed Performantica, Iasi

41.

El-Hefian EA, Nasef MM, Yahaya AH (2011) Preparation and characterization of chitosan/poly(vinyl alcohol) blended films: mechanical, thermal and surface investigations. E-J Chem 8(1):91–96. https://doi.org/10.1155/2011/969062 CrossRef

42.

Straccia MC, Romano I, Oliva A, Santagata G, Laurienzo P (2014) Crosslinker effects on functional properties of alginate/N-succinyl chitosan based hydrogels. Carbohydr Polym 108:321–330. https://doi.org/10.1016/j.carbpol.2014.02.054 CrossRefPubMed

43.

Joseph G, Koshy J, Kallanickal PM (2013) Tensile properties of PMMA/SAN blends at different temperatures. Int J Eng Sci Innov Technol (IJESIT) 2(5):341–344

44.

Kanatt SR, Rao MS, Chawla SP, Sharma A (2012) Active chitosan–polyvinyl alcohol films with natural extract. Food Hydrocoll 29:290–297. https://doi.org/10.1016/j.foodhyd.2012.03.005 CrossRef

45.

Ali M, Gherissi A (2017) Synthesis and characterization of the composite material PVA/chitosan/5% sorbitol with different ratio of chitosan. IJMME-IJENS 17(02):15–28

46.

Vimala K, Mohan YM, Varaprasad K, Redd NN, Ravindra S, Naidu NS, Raju KM (2011) Fabrication of curcumin encapsulated chitosan–PVA silver nanocomposite films for improved antimicrobial activity. J Biomater Nanobiotechnol 2:55–64. https://doi.org/10.4236/jbnb.2011.21008 CrossRef

47.

Mangala E, Suresh Kumar T, Baskar S, Panduranga Rao K (2003) Development of chitosan/poly(vinyl alcohol) blend membranes as burn dressings. Trends Biomater Artif Organs 17(1):34–40

48.

Li M-C, Wu Q, Song K, Cheng HN, Suzuki S, Lei T (2016) Chitin nanofibers as reinforcing and antimicrobial agents in carboxymethyl cellulose films: influence of partial deacetylation. ACS Sustain Chem Eng 4(8):4385–4395. https://doi.org/10.1021/acssuschemeng.6b00981 CrossRef

49.

Swathi V, Vidyavathi M, Prasad TNVKV, Suresh Kumar RV (2013) Comparison of different nano biocomposites of neomycin with marketed ointment by in vitro and in vivo evaluations. Int J Drug Deliv 5:438–448

50.

Gowda ADV, Gowrav MP, Srivastava A, Osmani RAM (2016) A study of chitosan nanofibers containing neomycin sulphate for wound healing activity. Der Pharmacia Lettre 8(11):128–139

Titel: Preparation and characterization of chitosan–poly(vinyl alcohol)–neomycin sulfate films
verfasst von: Irina Paula Merlusca
Doina Simona Matiut
Gabriela Lisa
Mihaela Silion
Luiza Gradinaru
Stefan Oprea
Ionel Marcel Popa
Publikationsdatum: 23.11.2017
Verlag: Springer Berlin Heidelberg
Erschienen in: Polymer Bulletin / Ausgabe 9/2018
Print ISSN: 0170-0839
Elektronische ISSN: 1436-2449
DOI: https://doi.org/10.1007/s00289-017-2246-1

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