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27.01.2017 | Original Paper

Fabrication, characterization and evaluation of bacterial cellulose-based capsule shells for oral drug delivery

verfasst von: Hanif Ullah, Munair Badshah, Ermei Mäkilä, Jarno Salonen, Mohammad-Ali Shahbazi, Hélder A. Santos, Taous Khan

Erschienen in: Cellulose | Ausgabe 3/2017

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Abstract

Bacterial cellulose (BC) was investigated for the first time for the preparation of capsule shells for immediate and sustained release of drugs. The prepared capsule shells were characterized using X-ray diffraction, scanning electron microscopy and Fourier transform infrared spectroscopy. The BC capsule shells were studied for drug release using an USP type-I dissolution apparatus. Irrespective of the drying method and the thickness of the BC sheet, the capsule shells displayed an immediate drug release profile. Moreover, the addition of release-retardant cellulosic polymers sustained the drug release having first-order kinetics for hydroxypropylmethylcellulose and carboxymethyl cellulose sodium with R ² values of 0.9995 and 0.9954, respectively. Furthermore, these capsules shells remained buoyant in 0.1 N HCl (pH 1.2) solution up to 12 h. This study showed that BC is a promising alternative to gelatin capsules with both immediate and sustained drug release properties depending upon the compositions of the encapsulated materials.

Vorheriger Artikel Grafting of arginine and glutamic acid onto cellulose for enhanced uranyl sorption

Nächster Artikel Chitosan-modified Pd(II)-d-penicillamine: preparation, characterization, and catalyst application

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Titel: Fabrication, characterization and evaluation of bacterial cellulose-based capsule shells for oral drug delivery
verfasst von: Hanif Ullah
Munair Badshah
Ermei Mäkilä
Jarno Salonen
Mohammad-Ali Shahbazi
Hélder A. Santos
Taous Khan
Publikationsdatum: 27.01.2017
Verlag: Springer Netherlands
Erschienen in: Cellulose / Ausgabe 3/2017
Print ISSN: 0969-0239
Elektronische ISSN: 1572-882X
DOI: https://doi.org/10.1007/s10570-017-1202-4

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