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Polymer Bulletin
Erschienen in: Polymer Bulletin 5/2010

01.09.2010 | Original Paper

Novel hyperbranched poly (amine-ester)-poly (lactide-co-glycolide) polymeric micelles as amphotericin B carriers

verfasst von: Tiewei Wang, Yan Wu, Mingjun Li

Erschienen in: Polymer Bulletin | Ausgabe 5/2010

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Abstract

A series of amphiphilic hyperbranched poly (amine-ester)-poly (lactide-co-glycolide) (HPAE-co-PLGA) copolymers were synthesized by ring-opening polymerization of dl-lactide, glycolide and a fourth generation hyperbranched poly (amine-ester) (HPAE-OHs4) with Sn(Oct)2 as catalyst. The chemical structure of copolymers was characterized by Fourier transform infrared (FT-IR), nuclear magnetic resonance (1H-NMR, 13C-NMR), thermo gravimetric analysis apparatus (TGA), and different scanning calorimetry (DSC). Formation and characteristics of polymeric micelles of the amphiphilic copolymer were studied by environmental scanning electron microscopy (ESEM), fluorescence spectroscopy, and dynamic light scattering (DLS). In order to estimate the feasibility as novel drug carriers, a lipophilic model drug amphotericin B was incorporated into polymeric micelles and the drug release behavior was investigated. The micelle size and drug-loading content were found increased, and the drug-release rate decreased with the increase of molar ratio of dl-lactide/glycolide to HPAE.
Nächster Artikel Chemical modification of polysaccharides by the use of intramolecular associations in polar organic solvents

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Literatur
1.
Hans M, Shimoni K, Danino D, Siegel SJ, Lowman A (2005) Synthesis and characterization of mPEG-PLA prodrug micelles. Biomacromolecules 6:2708–2717CrossRef
2.
Lin R, Ng LS, Wang CH (2005) In vitro study of anticancer drug doxorubicin in PLGA-based microparticles. Biomaterials 26:4476–4485CrossRef
3.
Wang C, Wang C, Hsiue GH (2005) Polymeric micelles with a pH-responsive structure as intracellular drug carriers. J Control Release 108:140–149CrossRef
4.
Agrawal SK, Sanabria-DeLong N, Coburn JM, Tew GN, Bhatia SR (2006) Novel drug release profiles from micellar solutions of PLA–PEO–PLA triblock copolymers. J Control Release 112:64–71CrossRef
5.
Jiang XZ, Zhang JY, Zhou YM, Xu J, Liu SY (2008) Facile preparation of core-crosslinked micelles from azide-containing thermoresponsive double hydrophilic diblock copolymer via click chemistry. J Polym Sci A Polym Chem 46:860–871CrossRef
6.
Riess G (2003) Micellization of block copolymers. Prog Polym Sci 28:1107–1170CrossRef
7.
Ryu JG, Jeong YI, Kim IS, Lee JH, Nah JW, Kim SH (2000) Clonazepam release from core–shell type nanoparticles of poly(ε-caprolactone)/poly(ethylene glycol)/poly(ε-caprolactone) triblock copolymers. Int J Pharm 200:231–242CrossRef
8.
Lo CL, Huang CK, Lin KM, Hsiue GH (2007) Mixed micelles formed from graft and diblock copolymers for application in intracellular drug delivery. Biomaterials 28:1225–1235CrossRef
9.
Han HD, Shin BC, Choi HS (2006) Doxorubicin-encapsulated thermosensitive liposomes modified with poly (N-isopropylacrylamide-co-acrylamide): drug release behavior and stability in the presence of serum. Eur J Pharm Biopharm 62:110–116CrossRef
10.
Yoo HS, Park TG (2001) Biodegradable polymeric micelles composed of doxorubicin conjugated PLGA–PEG block copolymer. J Control Release 70:63–70CrossRef
11.
Layre A, Couvreur P, Chacun H, Richard J, Passirani C, Requier D, Benoit JP, Gref R (2006) Novel composite core–shell nanoparticles as busulfan carriers. J Control Release 111:271–280CrossRef
12.
Li YY, Zhang XZ, Kim GC, Cheng H, Cheng SX, Zhuo RX (2006) Thermosensitive Y-shaped micelles of poly(oleic acid-Y-N-isopropylacrylamide) for drug delivery. Small 2:917–923CrossRef
13.
Gao C, Yan D (2004) Hyperbranched polymers: from synthesis to applications. Prog Polym Sci 29:183–275CrossRef
14.
Voit B (2000) New developments in hyperbranched polymers. J Polym Sci A Polym Chem 38:2505–2525CrossRef
15.
Tian HY, Deng C, Lin H, Sun JR, Deng MX, Chen XS, Jing XB (2005) Biodegradable cationic PEG-PEI-PBLG hyperbranched block copolymer: synthesis and micelle characterization. Biomaterials 26:4209–4217CrossRef
16.
Rajesh KK, Muthiah G, Munia G, Tanay G, Donald EB, Souvik M, Jayachandran NK (2006) Blood compatibility of novel water soluble hyperbranched polyglycerol-based multivalent cationic polymers and their interaction with DNA. Biomaterials 27:5377–5390CrossRef
17.
Karger-Kocsis J, Fröhlich J, Gryshchuk O, Kautz H, Frey H, Mülhaupt R (2004) Synthesis of reactive hyperbranched and star-like polyethers and their use for toughening of vinylester-urethane hybrid resins. Polymer 45:1185–1195CrossRef
18.
Gao C, Xu Y, Yan D, Chen W (2003) Water-soluble degradable hyperbranched polyesters: novel candidates for drug delivery? Biomacromolecules 4:704–712CrossRef
19.
Kolhe P, Misra E, Kannan RM, Kannan S, Lieh-Lai M (2003) Drug complexation, in vitro release and cellular entry of dendrimers and hyperbranched polymers. Int J Pharm 259:143–160CrossRef
20.
Kim HJ, Kwon MS, Choi JS, Kim BH, Yoon JK, Kim K, Park JS (2007) Synthesis and characterization of poly (amino ester) for slow biodegradable gene delivery vector. Bioorg Med Chem 15:1708–1715CrossRef
21.
Jeong B, Bae YH, Kim SW (2000) Drug release from biodegradable injectable thermosensitive hydrogel of PEG-PLGA-PEG triblock copolymers. J Control Release 63:155–163CrossRef
22.
Blanco MD, Alonso MJ (1997) Development and characterization of protein-loaded poly (lactide-co-glycolide) nanospheres. Eur J Pharm Biopharm 43:287–294CrossRef
23.
Yang R, Yang SG, Shim WS, Cui F, Cheng G, Kim IW, Kim DD, Chung SJ, Shim CK (2009) Lung-specific delivery of paclitaxel by chitosan-modified PLGA nanoparticles via transient formation of microaggregates. J Pharm Sci 98:970–984CrossRef
24.
Thomas PA (1994) Mycotic keratitis-an underestimated mycosis. J Med Vet Mycol 32:235–256CrossRef
25.
Essman TF, Flynn HW Jr, Smiddy WE, Brod RD, Murray TG, Davis JL, Rubsamen PE (1997) Treatment outcomes in a 10-year study of endogenous fungal endophthalmitis. Ophthalmic Surg Lasers 28:185–194
26.
Zhu BK, Wei XZ, Xiao L, Xu YY, Geckeler KE (2006) Preparation and properties of hyperbranched poly (amine-ester) films using acetal cross-linking units. Polym Int 55:63–70CrossRef
27.
Dong YC, Feng SS (2004) Methoxy poly(ethylene glycol)-poly(lactide) (MPEG-PLA) nanoparticles for controlled delivery of anticancer drugs. Biomaterials 25:2843–2849CrossRef
28.
Lu Y, Lin D, Wei HY, Shi WF (2001) Synthesis and characterization of hyperbranched poly(amine-ester). Acta Polymer Sin 4:411–414
29.
Karayannidis GP, Roupakias CP, Bikiaris DN, Achilias DS (2003) Study of various catalysts in the synthesis of poly (propylene terephthalate) and mathematical modeling of the esterification reaction. Polymer 44:931–942CrossRef
30.
Zhang LM (2001) Cellulosic associative thickeners. Carbohydr Polym 45:1–10CrossRef
31.
Shin IG, Kim SY, Lee YM, Cho CS, Sung YK (1998) Methoxy poly(ethylene glycol)/ε-caprolactone amphiphilic block copolymeric micelle containing indomethacin. I. Preparation and characterization. J Control Release 51:1–11CrossRef
32.
Niwa T, Takeuchi H, Hino T, Kunou N, Kawashima Y (1993) Preparations of biodegradable nanospheres of water-soluble and insoluble drugs with d, l-lactide/glycolide copolymer by a novel spontaneous emulsification solvent diffusion method, and the drug release behavior. J Control Release 25:89–98CrossRef
Metadaten
Titel
Novel hyperbranched poly (amine-ester)-poly (lactide-co-glycolide) polymeric micelles as amphotericin B carriers
verfasst von
Tiewei Wang
Yan Wu
Mingjun Li
Publikationsdatum
01.09.2010
Verlag
Springer-Verlag
Erschienen in
Polymer Bulletin / Ausgabe 5/2010
Print ISSN: 0170-0839
Elektronische ISSN: 1436-2449
DOI
https://doi.org/10.1007/s00289-009-0218-9

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