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Journal of Nanoparticle Research

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01.08.2014 | Review

Overview of nano-drugs characteristics for clinical application: the journey from the entry to the exit point

verfasst von: Tanima Bose, Diane Latawiec, Partha Pratim Mondal, Subhra Mandal

Erschienen in: Journal of Nanoparticle Research | Ausgabe 8/2014

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Abstract

The ever-increasing number of diseases worldwide requires comprehensive, efficient, and cost-effective modes of treatments. Among various strategies, nanomaterials fulfill most of these criteria. The unique physicochemical properties of nanoparticles have made them a premier choice as a drug or a drug delivery system for the purpose of treatment, and as bio-detectors for disease prognosis. However, the main challenge is the proper consideration of the physical properties of these nanomaterials, while developing them as potential tools for therapeutics and/or diagnostics. In this review, we focus mainly on the characteristics of nanoparticles to develop an effective and sensitive system for clinical purposes. This review will present an overview of the important properties of nanoparticles, through their journey from its route of administration until disposal from the human body after accomplishing targeted functionality. We have chosen cancer as our model disease to explain the potentiality of nano-systems for therapeutics and diagnostics in relation to several organs (intestine, lung, brain, etc.). Furthermore, we have discussed their biodegradability and accumulation probability which can cause unfavorable side effects in healthy human subjects.

Vorheriger Artikel Emerging patterns for engineered nanomaterials in the environment: a review of fate and toxicity studies

Nächster Artikel Radiolytic synthesis of iridium nanoparticles onto carbon nanotubes

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Titel: Overview of nano-drugs characteristics for clinical application: the journey from the entry to the exit point
verfasst von: Tanima Bose
Diane Latawiec
Partha Pratim Mondal
Subhra Mandal
Publikationsdatum: 01.08.2014
Verlag: Springer Netherlands
Erschienen in: Journal of Nanoparticle Research / Ausgabe 8/2014
Print ISSN: 1388-0764
Elektronische ISSN: 1572-896X
DOI: https://doi.org/10.1007/s11051-014-2527-7

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