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Polymer Bulletin
Erschienen in: Polymer Bulletin 3/2013

01.03.2013 | Original Paper

Polyacrylamide gels with ionized functional groups in their selective recognition of trimeric molecular form of human growth hormone

verfasst von: Rimantas Kublickas, Giedrė Jarienė

Erschienen in: Polymer Bulletin | Ausgabe 3/2013

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Abstract

Networks of polyacrylamide with ionized functional groups were studied for the possibility of imprinting of oligomeric form of human growth hormone (hGH). Trimeric molecular form of hGH was molecularly imprinted for the first time. The results show that approximately 35–40 % (w/w) of the templates (depending on polymerization conditions) could be extracted from the molecularly imprinted acrylamide polymers. Artificial gel antibodies against trimeric hGH in the form of granules of hydrogel were compared with granules of non-imprinted polymer. Investigation of the binding to imprinted polymer of the template hormone, other molecular forms of the hormone, and other proteins shows enough high selectivity of artificial gel antibodies.
Vorheriger Artikel Low band gap Schiff base polymers obtained by complexation with Lewis acids
Nächster Artikel Improving the ring-opening polymerization of ε-caprolactone and l-lactide using stannous octanoate

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Metadaten
Titel
Polyacrylamide gels with ionized functional groups in their selective recognition of trimeric molecular form of human growth hormone
verfasst von
Rimantas Kublickas
Giedrė Jarienė
Publikationsdatum
01.03.2013
Verlag
Springer-Verlag
Erschienen in
Polymer Bulletin / Ausgabe 3/2013
Print ISSN: 0170-0839
Elektronische ISSN: 1436-2449
DOI
https://doi.org/10.1007/s00289-012-0863-2

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