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03.11.2020 | Original Contribution

Preparation and characterization of amphiphilic nanoparticles based on chondroitin sulfate A conjugated with hydrophobic drug for enhanced doxorubicin delivery

verfasst von: Xin Xie, Zhen Yuan, Qinglan Yuan, Yuyou Huang, Qunying Yu, Jin Ren, Liang Liang, Hongguang Jin, Jingmou Yu

Erschienen in: Colloid and Polymer Science | Ausgabe 1/2021

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Abstract

Novel chondroitin sulfate A conjugated doxorubicin (CSA-DOX) was synthesized and characterized. The mean diameter of CSA-DOX was 152 nm analyzed by dynamic light scattering (DLS). Further, DOX was physically encapsulated into the CSA-DOX nanoparticles. Total amounts of DOX in three kinds of DOX-loaded CSA-DOX (CSA-DOX/DOX) nanoparticles were from 21.8 to 24.2%. The mean diameters of three CSA-DOX/DOX nanoparticles were in the range of 167–177 nm. The shape of CSA-DOX/DOX nanoparticles was almost spherical. DOX released from DOX-loaded nanoparticles exhibited a biphasic way in phosphate buffered saline (PBS, pH 7.4). Cellular uptake studies exhibited that CSA-DOX and CSA-DOX/DOX nanoparticles could enhance the uptake of DOX into CD44 receptor-positive A549 cells. Moreover, the cytotoxicity of CSA-DOX/DOX nanoparticles against A549 cells significantly improved in contrast with free DOX and CSA-DOX nanoparticles. These results suggested that CSA-DOX copolymer could be a potential carrier for antitumor drug delivery.

Vorheriger Artikel Micellar characteristics of an amphiphilic star-block copolymer in DES-water mixture

Nächster Artikel Hybrids containing zirconium and phosphorus compounds obtained by sol-gel method

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Titel: Preparation and characterization of amphiphilic nanoparticles based on chondroitin sulfate A conjugated with hydrophobic drug for enhanced doxorubicin delivery
verfasst von: Xin Xie
Zhen Yuan
Qinglan Yuan
Yuyou Huang
Qunying Yu
Jin Ren
Liang Liang
Hongguang Jin
Jingmou Yu
Publikationsdatum: 03.11.2020
Verlag: Springer Berlin Heidelberg
Erschienen in: Colloid and Polymer Science / Ausgabe 1/2021
Print ISSN: 0303-402X
Elektronische ISSN: 1435-1536
DOI: https://doi.org/10.1007/s00396-020-04778-2

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