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Polymer Bulletin
Erschienen in: Polymer Bulletin 11/2023

09.12.2022 | Original Paper

Preparation and properties of homogeneous oxidized sodium alginate/silica/polyacrylamide–gelatin composite hydrogel based on interpenetrating network technology

verfasst von: Dongze Li, Yuqing Liao, Xiuqiong Chen, Hongcai Wang, Yanshi Wen, Kaiyue Cheng, Weiwei Chen, Huiqiong Yan, Qiang Lin

Erschienen in: Polymer Bulletin | Ausgabe 11/2023

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Abstract

To address the functional defect of alginate hydrogel in tissue engineering applications, we adopted the interpenetrating polymer network technology as well as the incorporation of SiO2 nanoparticles and the surface coverage of gelatin to fabricate homogeneous oxidized sodium alginate/silica/polyacrylamide–gelatin (OSA/SiO2/PAM-GT) composite hydrogels, using hydroxyapatite/D-glucono-δ-lactone (HAP/GDL) complex as the gelling system. Specially, the effect of SiO2 nanoparticles on the microstructure, mechanical properties, in vitro swelling, biodegradability, biomineralization and biocompatibility of the composite hydrogels was investigated. The resultant OSA/SiO2/PAM-GT composite hydrogels exhibited relatively regular 3D morphology with well-developed pore structure with HAP/GDL as the cross-linking agents. The incorporation of SiO2 nanoparticles could effectively regulate the pore structure, mechanical properties, swelling ratio, in vitro biodegradability and biomineralization of OSA/SiO2/PAM-GT composite hydrogels. Meanwhile, the OSA/SiO2/PAM-GT composite hydrogels could also support the adhesion, proliferation and differentiation of MG-63 cells, which could be applied to the tissue engineering field.
Vorheriger Artikel Analysis of the physical, mechanical and morphological properties of polyethylene terephthalate polymer in the manufacture of dentistry prosthetic components
Nächster Artikel Synthesis of PVA/Fe3O4@SiO2@CPS@SID@Ni as novel magnetic fibrous composite polymer nanostructures and evaluation of anti-cancer and antimicrobial activity

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Metadaten
Titel
Preparation and properties of homogeneous oxidized sodium alginate/silica/polyacrylamide–gelatin composite hydrogel based on interpenetrating network technology
verfasst von
Dongze Li
Yuqing Liao
Xiuqiong Chen
Hongcai Wang
Yanshi Wen
Kaiyue Cheng
Weiwei Chen
Huiqiong Yan
Qiang Lin
Publikationsdatum
09.12.2022
Verlag
Springer Berlin Heidelberg
Erschienen in
Polymer Bulletin / Ausgabe 11/2023
Print ISSN: 0170-0839
Elektronische ISSN: 1436-2449
DOI
https://doi.org/10.1007/s00289-022-04631-2

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