The study of the roles of substance P and related neurokinins in periphery is particularly complicated by the fact that these peptides are present in a variety of neural and non-neural structures. Thus, substance P immunoreactivity of the adrenal gland is found in chromaffin cells and also in sensory neurons; in the carotid body, in glomic cells and afferent fibers; in the gut, in sensory afferents as well as in intrinsic networks and also in the so-called enterochromaffin cells of the mucosa. Much of the work presented in this section of the symposium refers to attempts to elucidate the specific participation of neurokinins derived from these differential sources on the physiology of peripheral systems. In this chapter, we will summarize some aspects of the organization and physiology of substance P containing peripheral sensory branches in the skin and autonomic ganglia.
Weitere Kapitel dieses Buchs durch Wischen aufrufen
- Effector Roles of Substance P in Peripheral Branches of Sensory Neurons
A. C. Cuello
- Springer New York
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