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13.12.2019 | Original Paper

Electrospun tubes based on PLA, gelatin and genipin in different arrangements for blood vessel tissue engineering

verfasst von: Abraham Alejandro Leyva-Verduzco, María Mónica Castillo-Ortega, Lerma Hanaiy Chan-Chan, Erika Silva-Campa, Ramsés Galaz-Méndez, Ricardo Vera-Graziano, José Carmelo Encinas-Encinas, Teresa Del Castillo-Castro, Dora Evelia Rodríguez-Félix, Hisila del Carmen Santacruz-Ortega, Irela Santos-Sauceda

Erschienen in: Polymer Bulletin | Ausgabe 11/2020

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Abstract

Four tubular membranes based on PLA and gelatin with different arrangements (PLA, gelatin, PLA-gelatin Blend and PLA/gelatin Core/Shell) were prepared by the electrospinning technique, the gelatin within the materials was crosslinked with genipin and all the meshes were characterized by SEM, ATR-FTIR, TGA, DSC, XRD and mechanical tests, also a viability essay and a confocal microscopy of HUVECs in contact with the materials were carried out. A 50% decrement of cellular viability was observed in the fibers with Core/Shell structure since the first day of culture compared with the tissue culture polystyrene, due to solubilization of non-crosslinked gelatin.

Vorheriger Artikel Mechanical properties and creep behavior of fluoroelastomer under hydrochloric acid environments

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Titel: Electrospun tubes based on PLA, gelatin and genipin in different arrangements for blood vessel tissue engineering
verfasst von: Abraham Alejandro Leyva-Verduzco
María Mónica Castillo-Ortega
Lerma Hanaiy Chan-Chan
Erika Silva-Campa
Ramsés Galaz-Méndez
Ricardo Vera-Graziano
José Carmelo Encinas-Encinas
Teresa Del Castillo-Castro
Dora Evelia Rodríguez-Félix
Hisila del Carmen Santacruz-Ortega
Irela Santos-Sauceda
Publikationsdatum: 13.12.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: Polymer Bulletin / Ausgabe 11/2020
Print ISSN: 0170-0839
Elektronische ISSN: 1436-2449
DOI: https://doi.org/10.1007/s00289-019-03057-7

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