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Polymer Bulletin
Erschienen in: Polymer Bulletin 10/2018

27.01.2018 | Original Paper

In situ gelation behavior of thermoresponsive poly(N-vinylpyrrolidone)/poly(N-isopropylacrylamide) microgels synthesized by soap-free emulsion polymerization

verfasst von: Tao Wang, Liang Jin, Yang Zhang, Yanan Song, Jiaxi Li, Yu Gao, Shan Shi

Erschienen in: Polymer Bulletin | Ausgabe 10/2018

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Abstract

Poly(N-vinylpyrrolidone)/poly(N-isopropylacrylamide) (PVP/PNIPAM) microgels were successfully synthesized by soap-free emulsion polymerization of N-isopropylacrylamide monomer in the presence of PVP, using an anionic radical initiator and a chemical crosslinker. The dried microgels exhibited nonspherical morphology and submicron size with good monodispersity. In aqueous phase, the microgels shrank when elevating temperature, displaying a negatively thermoresponsive nature with volume phase transition temperature (VPTT) of ca. 33.1 °C. The microgel dispersions remained colloidally stable even being heated far above their VPTT but gelled with the addition of electrolyte. Such thermo-induced in situ gelation behavior was studied in detail by small-deformation oscillatory rheological measurements within the linear viscoelastic region. The dynamic temperature ramp sweeps showed that the gelation temperature decreased independently as the polymer content or electrolyte concentration was increased. The isothermal time sweeps were performed to study the gelation kinetics. It was found that the microgel dispersions formed gel more quickly at larger polymer content, larger electrolyte concentration and higher temperature.
Vorheriger Artikel Properties and ammonia gas sensing applications of different inorganic acid-doped poly(2-chloroanilines)
Nächster Artikel Ionic liquids as coagents for sulfur vulcanization of butadiene–styrene elastomer filled with carbon black

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Literatur
1.
Guan Y, Zhang YJ (2011) PNIPAM microgels for biomedical applications: from dispersed particles to 3D assemblies. Soft Matter 7:6375–6384CrossRef
2.
Appel J, Lange N, Kooij HM, Laar T, Hove JB, Kodger TE, Sprakel J (2015) Temperature controlled sequential gelation in composite microgel suspensions. Part Part Syst Charact 32:764–770CrossRef
3.
Işiklan N, Küçükbalcı G (2016) Synthesis and characterization of pH- and temperature-sensitive materials based on alginate and poly(N-isopropylacrylamide)/acrylic acid) for drug delivery. Polym Bull 73:1321–1342CrossRef
4.
Zhao YB, Zheng CS, Wang Q, Fang JL, Zhou GF, Zhao H, Yang YJ, Xu HB, Feng GS, Yang XL (2011) Permanent and peripheral embolization: temperature-sensitive p(N-isopropylacrylamide-co-butyl methylacrylate) nanogels as a novel blood-vessel-embolic materials in the interventional therapy of liver tumors. Adv Funct Mater 21:2035–2042CrossRef
5.
Xiong W, Gao X, Zhao YB, Xu HB, Yang XL (2011) The dual temperature/pH-sensitive multiphase behavior of poly(N-isopropylacrylamide-co-acrylic acid) microgels for potential application in in situ gelling system. Colloid Surf B 84:103–110CrossRef
6.
Zhou J, Wang GN, Zou L, Tang LP, Marquez M, Hu ZB (2008) Viscoelastic behavior and in vivo release study of microgel dispersions with inverse thermoreversible gelation. Biomacromol 9:142–148CrossRef
7.
Wang Q, Xu HB, Yang XL, Yang YJ (2008) Drug release behavior from in situ gelatinized thermosensitive nanogel aqueous dispersions. Int J Pharm 361:189–193CrossRefPubMed
8.
Wang Q, Zhao YB, Yang YJ, Xu HB, Yang XL (2007) Thermosensitive phase behavior and drug release of in situ gelable poly(N-isopropylacrylamide-co-acrylamide) microgels. Colloid Polym Sci 285:515–521CrossRef
9.
Gan TT, Guan Y, Zhang YJ (2010) Thermogelable PNIPAM microgel dispersion as 3D cell scaffold: effect of syneresis. J Mater Chem 20:5937–5944CrossRef
10.
Gu JJ, Zhao YN, Guan Y, Zhang YJ (2015) Effect of particle size in colloidal hydrogel scaffold for 3D cell culture. Colloid Surf B 136:1139–1147CrossRef
11.
Cheng D, Wu YH, Guan Y, Zhang YJ (2012) Tuning properties of injectable hydrogel scaffold by PEG blending. Polymer 53:5124–5131CrossRef
12.
Gan TT, Zhang YJ, Guan Y (2009) In situ gelation of P(NIPAM-HEMA) dispersion and its applications as injectable 3D cell scaffold. Biomacromolecues 10:1410–1415CrossRef
13.
Cui X, Dini S, Dai S, Bi J, Binder BJ, Green JEF, Zhang H (2016) A mechanistic study on tumor spheroid formation in thermosensitive hydrogels: experiments and mathematical modeling. RSC Adv 6:73282–73291CrossRef
14.
Shen ZY, Mellati A, Bi JX, Zhang H, Dai S (2014) A thermally responsive cationic nanogel-based platform for three-dimensional cell culture and recovery. RSC Adv 4:29146–29156CrossRef
15.
Lou SF, Wang L, Williams GR, Nie HL, Quan J, Zhu LM (2014) Galactose functionalized injectable thermoresponsive microgels for sustained protein release. Colloid Surf B 113:368–374CrossRef
16.
Garrec DL, Gori S, Luo L, Lessard D, Smith DC, Yessine MA, Ranger M, Leroux JC (2004) Poly(N-vinylpyrrolidone)-block-poly(d, l-lactide) as a new polymeric solubilizer for hydrophobic anticancer drugs: in vitro and in vivo evaluation. J Controlled Release 99:83–101CrossRef
17.
Krezović BD, Miljković MG, Stojanović ST, Najman SJ, Filipović JM, Tomić SL (2017) Structural, thermal, mechanical, swelling, drug release, antibacterial and cytotoxic properties of P(HEA/IA)/PVP semi-IPN hydrogels. Chem Eng Res Des 121:368–380CrossRef
18.
Akdemir ZS, Kayaman-Apohan NK (2007) Investigation of swelling, drug release and diffusion behaviors of poly(N-isopropylacrylamide)/poly(N-vinylpyrrolidone) full-IPN hydrogels. Polym Adv Tech 18:932–939CrossRef
19.
Pound G, Mckenzie JM, Lange RFM, Klumperman B (2008) Polymer-protein conjugates from ω-aldehyde endfunctional poly(N-vinylpyrrolidone) synthesised via xanthate-mediated living radical polymerisation. Chem Commun 27(27):3193–3195CrossRef
20.
Chen GX, Liu JX, Yang YD, Zhang LJ, Wu M, Ni HM (2015) Preparation of pH-sensitive nanoparticles of poly(methacrylic acid)(PMAA)/poly(vinyl pyrrolidone)(PVP) by ATRP-template miniemulsion polymerization in the aqueous solution. Colloid Polym Sci 293:2035–2044CrossRef
21.
Peng H, Rübsam K, Jakob F, Schwaneberg U, Pich A (2016) Tunable enzymatic activity and enhanced stability of cellulose immobilized in biohybrid nanogels. Biomacromol 17:3619–3631CrossRef
22.
Yao XK, Xie C, Chen WZ, Yang CC, Wu W, Jiang XQ (2015) Platinum-incorporating poly(N-vinylpyrrolidone)-poly(aspartic acid) pseudoblock copolymer nanoparticles for drug delivery. Biomacromolecules 16:2059–2071CrossRefPubMed
23.
Yang Q, Wang K, Nie JJ, Du BY, Tang GP (2014) Poly(N-vinylpyrrolidone) microgels: preparation, biocompatibility and potential application as drug carriers. Biomacromol 15:2285–2293CrossRef
24.
Cong HL, Li L, Zheng SX (2013) Poly(N-isopropylacrylamide)-block-poly(vinyl pyrrolidone) block copolymer networks: synthesis and rapid thermoresponse of hydrogels. Polymer 54:1370–1380CrossRef
25.
Geever LM, Mínguez CM, Devine DM, Nugent MJD, Kennedy JE, Lyones JG, Hanley A, Devery S, Tomkins PT, Higginbotham CL (2007) The synthesis, swelling behavior and rheological properties of chemically crosslinked thermosensitive copolymers based on N-isopropylacrylamide. J Mater Sci 42:4136–4148CrossRef
26.
Geever LM, Devine DM, Nugent MJD, Kennedy JE, Lyones JG, Hanley A, Higginbotham CL (2006) Lower critical solution temperature control and swelling behavior of physically crosslinked thermosensitive copolymers based on N-isopropylacrylamide. Eur Polym J 42:2540–2548CrossRef
27.
Cong HL, Li JG, Li L, Zheng SX (2014) Thermoresponsive gelation behavior of poly(N-isopropylacrylamide)-block-poly(N-vinylpyrrolidone)-block-poly(N-isopropylacrylamide) triblock copolymers. Eur Polym J 61:23–32CrossRef
28.
Higgins W, Kozlovskaya V, Alford A, Ankner J, Kharlampieva E (2016) Stratified temperature-responsive multilayer hydrogels of poly(N-vinylpyrrolidone) and poly(N-vinylcaprolactam): effect of hydrogel architecture on properties. Macromolecules 49:6953–6964CrossRef
29.
Gilbert T, Smeets NMB, Hoare T (2015) Injectable interpenetrating network hydrogels via kinetically orthogonal reactive mixing of functionalized polymeric precursors. ACS Macro Lett 4:1104–1109CrossRef
30.
Zhu ZS, Li Y, Li XL, Li RT, Jia ZJ, Liu BR, Guo WH, Wu W, Jiang XQ (2010) Paclitaxel-loaded poly(N-vinylpyrrolidone)-b-poly(ε-caprolactone) nanoparticles: preparation and antitumor activity in vivo. J Controlled Release 142:438–446CrossRef
31.
Zhu ZS, Xie C, Liu Q, Zhen X, Zheng XC, Wu W, Li RT, Ding Y, Jiang XQ, Liu BR (2011) The effect of hydrophilic chain length and iRGD on drug delivery from poly(ε-caprolactone)-poly(N-vinylpyrrolidone) nanoparticles. Biomaterials 32:9525–9535CrossRefPubMed
32.
Kuskov AN, Kulikov PP, Goryachaya AV, Tzatzarakis MN, Docea AO, Velonia K, Shtilman MI, Tsatsakis AM (2017) Amphiphilic poly-N-vinylpyrrolidone nanoparticles as carriers for non-steroidal, anti-inflammatory drugs: in vitro cytotoxicity and in vivo acute toxicity study. Nanomed Nanotechnol 13:1021–1030CrossRef
33.
Ding Y, Gao J, Yang XY, He J, Zhou ZY, Hu Y (2014) Preparation of water dispersible, fluorescent Ag–PAA–PVP hybrid nanogels and their optical properties. Adv Powder Technol 25:244–249CrossRef
34.
El-Rehim HAA, Hegazy ESA, Hamed AA, Swilem AE (2013) Controlling the size and swellability of stimuli-responsive polyvinylpyrrolidone-poly(acrylic acid) nanogels synthesized by gamma radiation-induced template polymerization. Eur Polym J 49:601–612CrossRef
35.
Rehmani S, Ahmad M, Minhas MU, Anwar H, Zangi MI, Sohail M (2017) Development of natural and synthetic polymer-based semi-interpenetrating polymer network for controlled drug delivery: optimization and in vitro evaluation studies. Polym Bull 74:737–761CrossRef
36.
Huma F, Akhter Z, Yasin T, Zafar-uz-Zamman M, Manan A (2014) Crosslinking of poly(N-vinylpyrrolidone-co-n-butyl methacrylate) copolymers for controlled drug delivery. Polym Bull 71:433–451CrossRef
37.
Li XY, Weng JY, Guan Y, Zhang YJ (2016) Fabrication of large-area two-dimensional microgel colloidal crystals via interfacial thiol-ene click reaction. Langmuir 32:3977–3982CrossRefPubMed
38.
Ghorbani M, Hamishehkar H, Arsalani N, Entezami AA (2015) Preparation of thermo and pH-responsive polymer@Au/Fe3O4 core/shell nanoparticles as a carrier for delivery of anticancer agent. J Nanopart Res 17:305CrossRef
39.
Hoare T, Pelton R (2004) Functional group distributions in carboxylic acid containing poly(N-isopropylacrylamide) microgels. Langmuir 20:2123–2133CrossRefPubMed
40.
Shi S, Wang T, Bian LN, Zhou LM, Zhao LQ, Kuroda SI (2011) Nonspherical dented poly(methyl methacrylate)/poly(styrene-co-divinylbenzene) particles formed in seeded soap-free emulsion copolymerization. J Mater Sci 46:7214–7222CrossRef
41.
Wang ZF, Wang T, Bian LN, Zhou LM, Shi S, Kuroda SI (2011) Preparation of micron-sized nonspherical polystyrene/poly(styrene-co-ethyleneglycol dimethacrylate) particles by seeded soap-free emulsion polymerization. Chinese J Polym Sci 29:634–638CrossRef
42.
Shi S, Wang QM, Wang T, Ren SP, Gao Y, Wang N (2014) Thermo-, pH-, and light-responsive poly(N-isopropylacrylamide-co-methacrylic acid)-Au hybrid microgels prepared by the in situ reduction method based on Au-thiol chemistry. J Phys Chem B 118:7177–7186CrossRefPubMed
43.
Shi S, Zhang L, Wang T, Wang QM, Gao Y, Wang N (2013) Poly(N-isopropylacrylamide)-Au hybrid microgels: synthesis, characterization, thermally tunable optical and catalytic properties. Soft Matter 9:10966–10970CrossRef
44.
Tung CYM, Dynes PJ (1982) Relationship between viscoelastic properties and gelation in thermosetting systems. J Appl Polym Sci 27:569–574CrossRef
45.
Li L, Thangamathesvaran PM, Yue CY, Tam KC, Hu X, Lam YC (2001) Gel network structure of methylcellulose in water. Langmuir 17:8062–8068CrossRef
46.
O’Kane FE, Happe RP, Vereijken JM, Gruppen H, Boekel MAJS (2004) Heat-induced gelation of pea legumin: comparison with soybean glycinin. J Agric Food Chem 52:5071–5078CrossRefPubMed
47.
Liao W, Zhang YJ, Guan Y, Zhu XX (2011) Gelation kinetics of thermosensitive PNIPAM microgel dispersions. Macromol Chem Phys 212:2052–2060CrossRef
48.
Wang T, Jin L, Song YN, Li JX, Gao Y, Shi S (2017) Rheological study on the thermoinduced gelation behavior of poly(N-isopropylacrylamide-co-acrylic acid) microgel suspensions. J Appl Polym Sci 134:45259CrossRef
Metadaten
Titel
In situ gelation behavior of thermoresponsive poly(N-vinylpyrrolidone)/poly(N-isopropylacrylamide) microgels synthesized by soap-free emulsion polymerization
verfasst von
Tao Wang
Liang Jin
Yang Zhang
Yanan Song
Jiaxi Li
Yu Gao
Shan Shi
Publikationsdatum
27.01.2018
Verlag
Springer Berlin Heidelberg
Erschienen in
Polymer Bulletin / Ausgabe 10/2018
Print ISSN: 0170-0839
Elektronische ISSN: 1436-2449
DOI
https://doi.org/10.1007/s00289-018-2271-8

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