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Acta Mechanica Sinica
Erschienen in: Acta Mechanica Sinica 2/2019

04.04.2019 | Review Paper

Mechanical microenvironment as a key cellular regulator in the liver

verfasst von: Zhifeng You, Lyu Zhou, Wenjing Li, Chenyu Huang, Yanan Du

Erschienen in: Acta Mechanica Sinica | Ausgabe 2/2019

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Abstract

Tissue stiffness, shear stress, and interstitial pressure constitute major factors of the liver mechanical microenvironment that play a key regulatory role in controlling cell behavior in the liver and progression of liver diseases. In this review, we focus on the characteristics of the liver mechanical microenvironment and summarize cellular responses to mechanobiological changes during liver pathogenesis, especially in hepatic fibrosis and cirrhosis. A better understanding of the indispensable contribution of mechanical cues to liver homeostasis and pathogenesis is essential for identifying new therapeutic targets for liver diseases such as hepatic fibrosis or cirrhosis.
Vorheriger Artikel Mechanical force drives the polarization and orientation of cells
Nächster Artikel Nuclear mechanics during and after constricted migration

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Metadaten
Titel
Mechanical microenvironment as a key cellular regulator in the liver
verfasst von
Zhifeng You
Lyu Zhou
Wenjing Li
Chenyu Huang
Yanan Du
Publikationsdatum
04.04.2019
Verlag
The Chinese Society of Theoretical and Applied Mechanics; Institute of Mechanics, Chinese Academy of Sciences
Erschienen in
Acta Mechanica Sinica / Ausgabe 2/2019
Print ISSN: 0567-7718
Elektronische ISSN: 1614-3116
DOI
https://doi.org/10.1007/s10409-019-00857-y

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PREFACE

Mechanical microenvironments of living cells: a critical frontier in mechanobiology

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