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Erschienen in: Medical & Biological Engineering & Computing 6/2015

01.06.2015 | Original Article

A comparison between the principal stress direction and collagen fiber orientation in coronary atherosclerotic plaque fibrous caps

verfasst von: Catherine Pagiatakis, Ramses Galaz, Jean-Claude Tardif, Rosaire Mongrain

Erschienen in: Medical & Biological Engineering & Computing | Ausgabe 6/2015

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Abstract

The rupture of coronary atherosclerotic plaque fibrous caps has been associated with acute myocardial infarctions. Collagen fibers, the main structural component of vascular tissue, have been observed to change orientation and align themselves with the principal stress direction. This study compared the principal stress direction in stenosed coronary arteries obtained from 3D fluid–structure interaction simulations to the orientation of collagen fibers in the fibrous cap of human specimens. The principal stress direction at the peak of the stenosis was found to be axially oriented and correlated well with the determined orientation of the collagen fibers in the fibrous cap specimens.

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Metadaten
Titel
A comparison between the principal stress direction and collagen fiber orientation in coronary atherosclerotic plaque fibrous caps
verfasst von
Catherine Pagiatakis
Ramses Galaz
Jean-Claude Tardif
Rosaire Mongrain
Publikationsdatum
01.06.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
Medical & Biological Engineering & Computing / Ausgabe 6/2015
Print ISSN: 0140-0118
Elektronische ISSN: 1741-0444
DOI
https://doi.org/10.1007/s11517-015-1257-z

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