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Journal of Materials Engineering and Performance
Erschienen in: Journal of Materials Engineering and Performance 6/2016

02.05.2016

Influence of Fe3O4 Nanoparticles in Hydroxyapatite Scaffolds on Proliferation of Primary Human Fibroblast Cells

verfasst von: H. Maleki-Ghaleh, E. Aghaie, A. Nadernezhad, M. Zargarzadeh, A. Khakzad, M. S. Shakeri, Y. Beygi Khosrowshahi, M. H. Siadati

Erschienen in: Journal of Materials Engineering and Performance | Ausgabe 6/2016

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Abstract

Modern techniques for expanding stem cells play a substantial role in tissue engineering: the raw material that facilitates regeneration of damaged tissues and treats diseases. The environmental conditions and bioprocessing methods are the primary determinants of the rate of cultured stem cell proliferation. Bioceramic scaffolds made of calcium phosphate are effective substrates for optimal cell proliferation. The present study investigates the effects of two bioceramic scaffolds on proliferating cells in culture media. One scaffold was made of hydroxyapatite and the other was a mixture of hydroxyapatite and ferromagnetic material (Fe3O4 nanoparticles). Disk-shaped (10 mm × 2 mm) samples of the two scaffolds were prepared. Primary human fibroblast proliferation was 1.8- and 2.5-fold faster, respectively, when cultured in the presence of hydroxyapatite or ferrous nanoparticle/hydroxyapatite mixtures. Optical microscopy images revealed that the increased proliferation was due to enhanced cell-cell contact. The presence of magnetic Fe3O4 nanoparticles in the ceramic scaffolds significantly increased cell proliferation compared to hydroxyapatite scaffolds and tissue culture polystyrene.
Vorheriger Artikel Influence of Binder Adhesion Ability on the Performance of Silicon/Carbon Composite as Li-Ion Battery Anode
Nächster Artikel Effect of Annealing Treatment on Erosion-Corrosion of Zr-Based Bulk Metallic Glass in Saline-Sand Slurry

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Metadaten
Titel
Influence of Fe3O4 Nanoparticles in Hydroxyapatite Scaffolds on Proliferation of Primary Human Fibroblast Cells
verfasst von
H. Maleki-Ghaleh
E. Aghaie
A. Nadernezhad
M. Zargarzadeh
A. Khakzad
M. S. Shakeri
Y. Beygi Khosrowshahi
M. H. Siadati
Publikationsdatum
02.05.2016
Verlag
Springer US
Erschienen in
Journal of Materials Engineering and Performance / Ausgabe 6/2016
Print ISSN: 1059-9495
Elektronische ISSN: 1544-1024
DOI
https://doi.org/10.1007/s11665-016-2086-4

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