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Journal of Nanoparticle Research

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01.03.2013 | Research Paper

PAMAM dendrimer-coated iron oxide nanoparticles: synthesis and characterization of different generations

verfasst von: Rouhollah Khodadust, Gozde Unsoy, Serap Yalcın, Gungor Gunduz, Ufuk Gunduz

Erschienen in: Journal of Nanoparticle Research | Ausgabe 3/2013

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Abstract

This study focuses on the synthesis and characterization of different generations (G₀–G₇) of polyamidoamine (PAMAM) dendrimer-coated magnetic nanoparticles (DcMNPs). In this study, superparamagnetic iron oxide nanoparticles were synthesized by co-precipitation method. The synthesized nanoparticles were modified with aminopropyltrimethoxysilane for dendrimer coating. Aminosilane-modified MNPs were coated with PAMAM dendrimer. The characterization of synthesized nanoparticles was performed by X-ray diffraction, X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), dynamic light scattering, and vibrating sample magnetometry (VSM) analyses. TEM images demonstrated that the DcMNPs have monodisperse size distribution with an average particle diameter of 16 ± 5 nm. DcMNPs were found to be superparamagnetic through VSM analysis. The synthesis, aminosilane modification, and dendrimer coating of iron oxide nanoparticles were validated by FTIR and XPS analyses. Cellular internalization of nanoparticles was studied by inverted light scattering microscopy, and cytotoxicity was determined by XTT analysis. Results demonstrated that the synthesized DcMNPs, with their functional groups, symmetry perfection, size distribution, improved magnetic properties, and nontoxic characteristics could be suitable nanocarriers for targeted cancer therapy upon loading with various anticancer agents.

Vorheriger Artikel Ge quantum dot lattices in Al2O3 multilayers

Nächster Artikel In vitro evaluation of antitumor activity of doxorubicin-loaded nanoemulsion in MCF-7 human breast cancer cells

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Titel: PAMAM dendrimer-coated iron oxide nanoparticles: synthesis and characterization of different generations
verfasst von: Rouhollah Khodadust
Gozde Unsoy
Serap Yalcın
Gungor Gunduz
Ufuk Gunduz
Publikationsdatum: 01.03.2013
Verlag: Springer Netherlands
Erschienen in: Journal of Nanoparticle Research / Ausgabe 3/2013
Print ISSN: 1388-0764
Elektronische ISSN: 1572-896X
DOI: https://doi.org/10.1007/s11051-013-1488-6

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