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Colloid and Polymer Science
Erschienen in: Colloid and Polymer Science 2/2019

06.01.2019 | Original Contribution

Polyethylene glycol–modified molybdenum oxide as NIR photothermal agent and its ablation ability for HeLa cells

verfasst von: Hongyun Zou, Dongyan Tang, Ning Wang, Shuyue Jia, Zhaojie Sun, Xu Yang, Jing Peng

Erschienen in: Colloid and Polymer Science | Ausgabe 2/2019

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Abstract

Molybdenum oxide, as one of the important transition metal semiconductor materials with photothermal property, has received increasing attention in the field of catalysis, sensing, energy storage, and clinical biomedicine. To improve its certain limitations such as poor biocompatibility and easy agglomeration during application as biomaterials and promote its performance as photothermal agent in biomedical fields, polyethylene glycol (PEG)–modified molybdenum oxide was synthesized and the synthesis conditions during the hydrothermal process, including the pH values and the amount of PEG added, were adjusted. Owing to the reduction function of PEG, as-obtained PEG-MoOx showed good photostability and colloidal stability, which were beneficial to its application in long-term clinical photothermal therapy. In addition, cell experiments indicated that PEG-MoOx particles exhibited low cytotoxicity and ability of photothermal killing for HeLa cells. With the increase PEG-MoOx particles in solution, the photothermal ablation ability of PEG-MoOx particles for the HeLa cells was enhanced under an 808-nm NIR laser irradiation. Hence, PEG-MoOx particles have great potential in the photothermal treatment of diseases.
Vorheriger Artikel In situ hyper-cross-linking of glycidyl methacrylate–based polyHIPEs through the amine-enriched high internal phase emulsions
Nächster Artikel A novel stimulus-responsive temozolomide supramolecular vesicle based on host–guest recognition

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Metadaten
Titel
Polyethylene glycol–modified molybdenum oxide as NIR photothermal agent and its ablation ability for HeLa cells
verfasst von
Hongyun Zou
Dongyan Tang
Ning Wang
Shuyue Jia
Zhaojie Sun
Xu Yang
Jing Peng
Publikationsdatum
06.01.2019
Verlag
Springer Berlin Heidelberg
Erschienen in
Colloid and Polymer Science / Ausgabe 2/2019
Print ISSN: 0303-402X
Elektronische ISSN: 1435-1536
DOI
https://doi.org/10.1007/s00396-018-04460-8

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