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Polymer Bulletin
Erschienen in: Polymer Bulletin 3/2013

01.03.2013 | Original Paper

Preparation and characterization of ortho-biguanidinyl benzoyl chitosan hydrochloride and its antibacterial activities

verfasst von: Zhao-sheng Cai, Yue-ming Sun, Xue-mei Zhu, Lin-lin Zhao, Gui-yun Yue

Erschienen in: Polymer Bulletin | Ausgabe 3/2013

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Abstract

A novel derivative of chitosan (CTS), ortho-biguanidinyl benzoyl chitosan hydrochloride (o-BGBCH), was prepared with CTS and ortho-biguanidinyl benzoyl chloride, which was synthesized by acid chloride reaction of ortho-biguanidinyl benzonic acid hydrochloride (o-BGBA), as starting material in the medium consisted of methylsulfonic acid (MeSO3H) and dimethyl sulfoxide. Structure of o-BGBCH was characterized by FT-IR and 1H NMR, molecular weight of o-BGBCH was determined through gel permeation chromatography, and degree of substitution (DS) of guanidinylation of o-BGBCH was measured using elemental analysis technique. Meanwhile, the minimum inhibitory concentration of o-BGBCHs against Escherichia coli, a Gram-negative bacterium, and Staphylococcus aureus, a Gram-positive bacterium, were ascertained by agar plate method. Compared with CTS hydrochloride, o-BGBCHs had much stronger antimicrobial activities, and these activities improved with the increase of their DS of guanidinylation. When the DS of o-BGBCH reached or exceeded 32.7 %, its antibacterial activities against the tested bacteria were higher than that of Bromo-Geramium.
Vorheriger Artikel Synthesis and characterization of graft copolymer of sodium alginate and poly(itaconic acid) by the redox system

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Metadaten
Titel
Preparation and characterization of ortho-biguanidinyl benzoyl chitosan hydrochloride and its antibacterial activities
verfasst von
Zhao-sheng Cai
Yue-ming Sun
Xue-mei Zhu
Lin-lin Zhao
Gui-yun Yue
Publikationsdatum
01.03.2013
Verlag
Springer-Verlag
Erschienen in
Polymer Bulletin / Ausgabe 3/2013
Print ISSN: 0170-0839
Elektronische ISSN: 1436-2449
DOI
https://doi.org/10.1007/s00289-012-0883-y

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