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2013 | OriginalPaper | Buchkapitel

3. Selenium Atom-Specific Mutagenesis (SAM) for Crystallography, DNA Nanostructure Design, and Other Applications

verfasst von : Sibo Jiang, Huiyan Sun, Zhen Huang

Erschienen in: DNA Nanotechnology

Verlag: Springer Berlin Heidelberg

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Abstract

Since oxygen and selenium are in the same elemental family, the replacement of oxygen in nucleic acids with selenium does not significantly change the local as well as overall structures, which preserves the nucleic acid structures in a predictable manner. Furthermore, the valuable differences in chemical and electronic properties enable various functions and applications, including crystallization, phase determination, and high-resolution structure determination in X-ray crystallography, base-pair high fidelity, nanotechnology, and molecular imaging. This chapter briefly introduces the selenium-modified nucleic acids (SeNA), the selenium atom-specific mutagenesis (SAM), and their potentials in DNA nanotechnology.

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Vorheriges Kapitel Functional Nucleic Acids for DNA Nanotechnology

Nächstes Kapitel Liposomes for DNA Nanotechnology: Preparation, Properties, and Applications

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Titel: Selenium Atom-Specific Mutagenesis (SAM) for Crystallography, DNA Nanostructure Design, and Other Applications
verfasst von: Sibo Jiang
Huiyan Sun
Zhen Huang
Verlag: Springer Berlin Heidelberg
Buch: DNA Nanotechnology
Print ISBN: 978-3-642-36076-3

Electronic ISBN: 978-3-642-36077-0

Copyright-Jahr: 2013
DOI: https://doi.org/10.1007/978-3-642-36077-0_3

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