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Cognitive Neurodynamics

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01.07.2020 | Research Article

Synaptic dendritic activity modulates the single synaptic event

verfasst von: Vito Di Maio, Silvia Santillo, Francesco Ventriglia

Erschienen in: Cognitive Neurodynamics | Ausgabe 2/2021

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Abstract

Synaptic transmission is the key system for the information transfer and elaboration among neurons. Nevertheless, a synapse is not a standing alone structure but it is a part of a population of synapses inputting the information from several neurons on a specific area of the dendritic tree of a single neuron. This population consists of excitatory and inhibitory synapses the inputs of which drive the postsynaptic membrane potential in the depolarizing (excitatory synapses) or depolarizing (inhibitory synapses) direction modulating in such a way the postsynaptic membrane potential. The postsynaptic response of a single synapse depends on several biophysical factors the most important of which is the value of the membrane potential at which the response occurs. The concurrence in a specific time window of inputs by several synapses located in a specific area of the dendritic tree can, consequently, modulate the membrane potential such to severely influence the single postsynaptic response. The degree of modulation operated by the synaptic population depends on the number of synapses active, on the relative proportion between excitatory and inbibitory synapses belonging to the population and on their specific mean firing frequencies. In the present paper we show results obtained by the simulation of the activity of a single Glutamatergic excitatory synapse under the influence of two different populations composed of the same proportion of excitatory and inhibitory synapses but having two different sizes (total number of synapses). The most relevant conclusion of the present simulations is that the information transferred by the single synapse is not and independent simple transition between a pre- and a postsynaptic neuron but is the result of the cooperation of all the synapses which concurrently try to transfer the information to the postsynaptic neuron in a given time window. This cooperativeness is mainly operated by a simple mechanism of modulation of the postsynaptic membrane potential which influences the amplitude of the different components forming the postsynaptic excitatory response.

Vorheriger Artikel Energy dependence on discharge mode of Izhikevich neuron driven by external stimulus under electromagnetic induction

Nächster Artikel Neural mechanism of visual information degradation from retina to V1 area

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Titel: Synaptic dendritic activity modulates the single synaptic event
verfasst von: Vito Di Maio
Silvia Santillo
Francesco Ventriglia
Publikationsdatum: 01.07.2020
Verlag: Springer Netherlands
Erschienen in: Cognitive Neurodynamics / Ausgabe 2/2021
Print ISSN: 1871-4080
Elektronische ISSN: 1871-4099
DOI: https://doi.org/10.1007/s11571-020-09607-4

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