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2021 | OriginalPaper | Buchkapitel

From Autologous Flaps to Engineered Vascularized Grafts for Bone Regeneration

verfasst von : Alexander Haumer, Tarek Ismail, Alexander Lunger, Rik Osinga, Arnaud Scherberich, Dirk Johannes Schaefer, Ivan Martin

Erschienen in: Vascularization for Tissue Engineering and Regenerative Medicine

Verlag: Springer International Publishing

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Abstract

Replacement of damaged or lost tissue typically relies on the availability of living, functional substitutes and the rapid development of a stable and efficient vascularization upon transplantation, in order to guarantee their survival. These requirements challenge current surgical reconstruction techniques in the clinical practice.

In the past decades, the field of tissue engineering has introduced the possibility to combine materials and living cells to generate functional substitutes, which can be tailored to specific requirements of the implantation site. At the same time, plastic and reconstructive surgery has developed a large armamentarium of grafting possibilities and flaps supporting vascularization of native tissues, especially through progress made in microsurgical techniques.

In this chapter, we describe advances in the two fields and discuss how the principles and techniques independently developed could be combined towards the prefabrication of vascularized tissues. The resulting paradigm of “regenerative surgery,” here exemplified in the specific context of bone regeneration, could represent the future standard for the reconstruction of complex body parts.

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Titel: From Autologous Flaps to Engineered Vascularized Grafts for Bone Regeneration
verfasst von: Alexander Haumer
Tarek Ismail
Alexander Lunger
Rik Osinga
Arnaud Scherberich
Dirk Johannes Schaefer
Ivan Martin
Verlag: Springer International Publishing
Buch: Vascularization for Tissue Engineering and Regenerative Medicine
Print ISBN: 978-3-319-54584-4

Electronic ISBN: 978-3-319-54586-8

Copyright-Jahr: 2021
DOI: https://doi.org/10.1007/978-3-319-54586-8_16

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