Weitere Artikel dieser Ausgabe durch Wischen aufrufen
To test whether longitudinally measured health-related quality of life (HRQL) predicts transplant-related mortality (TRM) in pediatric hematopoietic stem cell transplant (HSCT).
The predictors of interest were emotional functioning, physical functioning, role functioning, and global HRQL, as rated by the parent about the child up to 6 times over 12 months of follow-up and measured by the Child Health Ratings Inventories. We used joint models, specifically shared parameter models, with time to TRM as the outcome of interest and other causes of mortality as a competing risk, via the JM software package in R. Choosing shared parameter models instead of standard survival models, such as Cox models with time-dependent covariates, enabled us to address measurement error in the HRQL trajectories and appropriately handle missing data. The nonlinear trajectories for each HRQL domain were modeled by random spline functions. The survival submodels were adjusted for baseline patient, family, and transplant characteristics.
Hazard ratios per one-half standard deviation difference in emotional, physical, and role functioning, and global HRQL were 0.61 (95 % CI 0.46–0.81; p < 0.001), 0.70 (0.51–0.96; p = 0.03), 0.54 (0.34–0.85; p = 0.007), and 0.57 (0.41–0.79; p < 0.001), respectively.
HRQL trajectories were predictive of TRM in pediatric HSCT, even after adjusting the survival outcome for baseline characteristics.
Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten
Sie möchten Zugang zu diesem Inhalt erhalten? Dann informieren Sie sich jetzt über unsere Produkte:
Parsons, S. K., Phipps, S., Sung, L., Baker, K. S., Pulsipher, M. A., & Ness, K. K. (2012). NCI, NHLBI/PBMTC first international conference on late effects after pediatric hematopoietic cell transplantation: Health-related quality of life, functional, and neurocognitive outcomes. Biology of Blood and Marrow Transplantation, 18, 162–171. PubMedCentralPubMedCrossRef
Parsons, S. K., Tighiouart, H., & Terrin, N. (2013). Assessment of health-related quality of life in pediatric hematopoietic stem cell transplant recipients: Progress, challenges and future directions. Expert Review of Pharmacoeconomics & Outcomes Research, 13, 217–225. CrossRef
Bonnetain, F., Paoletti, X., Collette, S., Doffoel, M., Bouche, O., Raoul, J. L., et al. (2008). Quality of life as a prognostic factor of overall survival in patients with advanced hepatocellular carcinoma: Results from two French clinical trials. Quality of Life Research, 17, 831–843. PubMedCrossRef
Sadetsky, N., Hubbard, A., Carroll, P. R., & Satariano, W. (2009). Predictive value of serial measurements of quality of life on all-cause mortality in prostate cancer patients: Data from CaPSURE (cancer of the prostate strategic urologic research endeavor) database. Quality of Life Research, 18, 1019–1027. PubMedCentralPubMedCrossRef
de Boer-van der Kolk, I. M., Sprangers, M. A., Prins, J. M., Smit, C., de Wolf, F., Nieuwkerk, P. T. (2010). Health-related quality of life and survival among HIV-infected patients receiving highly active antiretroviral therapy: A study of patients in the AIDS Therapy Evaluation in the Netherlands (ATHENA) Cohort. Clin Infect Dis, 50, 255–263.
Rumsfeld, J. S., MaWhinney, S., McCarthy, M, Jr, Shroyer, A. L., VillaNueva, C. B., O’Brien, M., et al. (1999). Health-related quality of life as a predictor of mortality following coronary artery bypass graft surgery. Participants of the Department of Veterans Affairs Cooperative Study Group on Processes, Structures, and Outcomes of Care in Cardiac Surgery. JAMA, 281, 1298–1303. PubMedCrossRef
Felder-Puig, R., di Gallo, A., Waldenmair, M., Norden, P., Winter, A., Gadner, H., et al. (2006). Health-related quality of life of pediatric patients receiving allogeneic stem cell or bone marrow transplantation: Results of a longitudinal, multi-center study. Bone Marrow Transplantation, 38, 119–126. PubMedCrossRef
Parsons, S. K., Shih, M. C., DuHamel, K. N., Ostroff, J., Mayer, D. K., Austin, J., et al. (2006). Maternal perspectives on children’s health-related quality of life during the first year after pediatric hematopoietic stem cell transplant. Journal of Pediatric Psychology, 31, 1100–1115. PubMedCrossRef
Parsons, S. K., Shih, M. C., Ratichek, S., Recklitis, C. J., & Chang G for the Journeys to Recovery Study. (2006). Establishing the baseline in longitudinal evaluation of health- related quality of life (HRQL): The pediatric hematopoietic stem cell transplantation (HSCT) Example. presentation at the patient- reported outcomes assessment in cancer trials, National Cancer Institute, September 2006.
Parsons, S. K., Shih, M. C., Mayer, D. K., Barlow, S. E., Supran, S. E., Levy, S. L., et al. (2005). Preliminary psychometric evaluation of the Child Health Ratings Inventories (CHRIs) and Disease-Specific Impairment Inventory-HSCT (DSII-HSCT) in parents and children. Quality of Life Research, 14, 1613–1625. PubMedCrossRef
Landgraf, J. M., & Abetz, L. (1994). The infant/toddler quality of life questionnaire: Conceptual framework, logic, content, and preliminary psychometric results. Final Report to Schering-Plough Laboratories and Health Technology Associates. Boston: New England Medical Center.
Xu, J., & Zeger, S. (2001). Joint analysis of longitudinal data comprising repeated measures and times to events. Applied Statistics, 50, 375–387.
Tsiatis, A. A., & Davidian, M. (2004). Joint modeling of longitudinal and time-to-event data: An overview. Statistica Sinica, 14, 809–834.
Rizopoulos, D. (2010). JM: An R package for the joint modelling of longitudinal and time-to-event data. Journal of Statistical Software, 35(9), 1–33.
Rizopoulos, D. (2012). Joint models for longitudinal and time-to-event data: With applications in R (1st ed.). New York: CRC Press. CrossRef
- Joint models for predicting transplant-related mortality from quality of life data
Angie Mae Rodday
Susan K. Parsons
- Springer International Publishing
Neuer Inhalt/© Stellmach, Neuer Inhalt/© BBL, Neuer Inhalt/© Maturus, Pluta Logo/© Pluta, Neuer Inhalt/© hww, So bewältigen Sie Stress im Fernstudium/© granata68 | stock.adobe.com | AdobeStock